Journal of Natural Medicines
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Published By Springer-Verlag

1861-0293, 1340-3443

Author(s):  
Dae-Won Ki ◽  
Seong-Eun Kim ◽  
Ji-Yul Kim ◽  
Ja-Gyeong Song ◽  
Byung Soon Hwang ◽  
...  
Keyword(s):  

Author(s):  
Kishor Mazumder ◽  
Biswajit Biswas ◽  
Abdullah Al Mamun ◽  
Hasan Billah ◽  
Ahsan Abid ◽  
...  

Author(s):  
Soo Ho Ryu ◽  
Chaeyeong Kim ◽  
Nayeon Kim ◽  
Wonhwa Lee ◽  
Jong-Sup Bae

Author(s):  
Mya Myat Ngwe Tun ◽  
Kazufumi Toume ◽  
Elizabeth Luvai ◽  
Khine Mya Nwe ◽  
Shusaku Mizukami ◽  
...  

Author(s):  
Yanglan Ou ◽  
Kohei Jobu ◽  
Tomoaki Ishida ◽  
Shumpei Morisawa ◽  
Hiroko Fujita ◽  
...  

AbstractSarcopenic obesity is associated with increased visceral fat and decreased muscle mass, resulting in decreased insulin sensitivity, increased production of inflammatory cytokines, and oxidative stress. In this study, we first evaluated the effects of herbal medicines on the transcriptional activity of the Sirtuin 1 (sirt1) promoter in vitro as an indicator of their therapeutic effect. Our data suggested that hot water Saikokeishikankyoto (SKK) extracts increased sirt1 transcriptional activity in vitro, identifying it as a candidate therapeutic for evaluation in the KKAy type 2 diabetic obesity mouse model. These in vivo evaluations revealed that SKK treatment increased the wet weight and muscle fiber content in cross sections of the gastrocnemius muscle (GA) and restored motor function in these animals. In addition, SKK treatment reduced tumor necrosis factor-α (TNFα) expression in the sera and suppressed Atrogin1 and MuRF1 transcription in the GA samples. This treatment also increased sirt1 expression in these tissues. These results suggest that SKK inhibits skeletal muscle atrophy and improves motor function in KKAy mice by suppressing inflammation. In actual clinical practice, SKK is expected to inhibit muscle atrophy and improve motor dysfunction in sarcopenic obesity. Graphical abstract


Author(s):  
Xiang-Wei Xu ◽  
Yi-Yuan Xi ◽  
Jun Chen ◽  
Feng Zhang ◽  
Ju-Jia Zheng ◽  
...  

Author(s):  
Fumiyuki Kiuchi

AbstractAchyranthes root is a crude drug used as diuretic, tonic and remedy for blood stasis. Characteristic oleanolic acid saponins with a dicarboxylic acid moiety have been isolated as one of the representative constituents of this crude drug. This review focuses on the triterpene saponin constituents, especially those with a characteristic dicarboxylic acid moiety, of A. bidentata and A. fauriei. Several groups isolated the saponins and different names were given to one compound in some cases. The names of the compounds are sorted out and the stereochemistry of the dicarboxylic acid moieties are summarized. HPLC analysis of the composition of the saponin constituents and the effect of processing and extraction conditions on the composition are reviewed. Biological activities of the saponin constituents are also summarized.


Author(s):  
Ken-ichi Nakashima ◽  
Yuka Higuchi ◽  
Junko Tomida ◽  
Yoshiaki Kawamura ◽  
Makoto Inoue

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