Inhibition of vascular endothelial growth factor (VEGF)-induced cell proliferation in the first trimester trophoblast cell line by cinnamon extract

Placenta ◽  
2021 ◽  
Vol 114 ◽  
pp. 140-141
Author(s):  
Toshihiro Sakurai ◽  
Jyunpei Abe ◽  
Rina Fukaya
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Cell Proliferation ◽  
Growth Factor ◽  
Cell Line ◽  
First Trimester ◽  
Trophoblast Cell ◽  
Vascular Endothelial ◽  
Cinnamon Extract ◽  
Endothelial Growth Factor ◽  
Trophoblast Cell Line

Expression and Regulation of Vascular Endothelial Growth Factor in a First Trimester Trophoblast Cell Line

Placenta ◽  
2000 ◽  
Vol 21 (4) ◽  
pp. 320-324 ◽  
Author(s):  
I-B. Chung ◽  
F.D. Yelian ◽  
F.M. Zaher ◽  
B. Gonik ◽  
M.I. Evans ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Cell Line ◽  
First Trimester ◽  
Trophoblast Cell ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor ◽  
Trophoblast Cell Line

scholarly journals The Involvement of Angiotensin Type 1 and Type 2 Receptors in Estrogen-Induced Cell Proliferation and Vascular Endothelial Growth Factor Expression in the Rat Anterior Pituitary

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Hanna Lawnicka ◽  
Dorota Ptasinska-Wnuk ◽  
Slawomir Mucha ◽  
Jolanta Kunert-Radek ◽  
Marek Pawlikowski ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Cell Proliferation ◽  
Growth Factor ◽  
Blood Vessels ◽  
Proliferation Index ◽  
Pituitary Cells ◽  
Vascular Endothelial ◽  
Vegf Expression ◽  
Rat Pituitary ◽  
Endothelial Growth Factor

The aim of our study was to examine the involvement of renin-angiotensin system (RAS) in estrogen-induced lactotropes proliferation and vascular endothelial growth factor (VEGF) expression in rat pituitary. The study was performed on Fisher 344 rats underwent 8-day treatment with diethylstilboestrol (DES). The proliferation index (PCNA) and VEGF expression in pituitary sections were estimated using immunohistochemical methods. Treatment with DES increased the number of PCNA-positive cells, VEGF-positive cells, and VEGF-positive blood vessels in pituitary. Stimulatory effect of estrogen on cell proliferation and VEGF expression in blood vessels was attenuated by losartan, PD123319, and captopril. VEGF immunoreactivity in pituitary cells of DES-treated rats was decreased by AT1 antagonist and not changed by AT2 blocker and ACE inhibitor. Our findings suggest the involvement of RAS in DES-induced cell proliferation and VEGF expression in pituitary. Both the AT1 and AT2 receptors appear to mediate the estrogen-dependent mitogenic and proangiogenic effects in rat pituitary.

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