Brain blood flow changes measured by positron emission tomography during an auditory cognitive task in healthy volunteers and in schizophrenic patients

2006 ◽  
Vol 30 (3) ◽  
pp. 516-520 ◽  
Author(s):  
Miklós Emri ◽  
Teodóra Glaub ◽  
Roland Berecz ◽  
Zsolt Lengyel ◽  
Pál Mikecz ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Healthy Volunteers ◽  
Cognitive Task ◽  
Emission Tomography ◽  
Brain Blood Flow ◽  
Positron Emission ◽  
Schizophrenic Patients ◽  
Flow Changes

Brain Blood Flow in the Nitroglycerin (Gtn) Model of Migraine: Measurement Using Positron Emission Tomography and Transcranial Doppler

Cephalalgia ◽  
2002 ◽  
Vol 22 (9) ◽  
pp. 749-757 ◽  
Author(s):  
EM Bednarczyk ◽  
DS Wack ◽  
MY Kassab ◽  
K Burch ◽  
K Trinidad ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Transcranial Doppler ◽  
Occipital Cortex ◽  
Anterior Cingulate ◽  
Emission Tomography ◽  
Brain Blood Flow ◽  
Positron Emission ◽  
Subcutaneous Sumatriptan ◽  
History Of

Nitroglycerin has been widely used as a model of experimental migraine. Studies combining measurement of flow velocity using transcranial Doppler (TCD) concurrently with measures of cerebral blood flow (CBF) are uncommon. We report the results of a study combining TCD and positron emission tomography (PET). Healthy volunteers with no personal or family history of migraine underwent measurement of CBF using H215O PET, and velocity using TCD. Measurements were done at baseline, and following i.v. nitroglycerin at 0.125, 0.25 and 0.5 μg/kg per min. Subcutaneous sumatriptan (6 mg) was injected, with CBF and velocity measured 15, 30, and 60 min later. Nitroglycerin was terminated and measurements obtained 30 min later. Six male and six female subjects were studied. Nitroglycerin increased global CBF while flow velocities decreased. Sumatriptan did not have a significant effect on these values. Regions of increased flow included the anterior cingulate, while regions of decreased flow included the occipital cortex. Our data suggest that nitroglycerin induces regional changes in CBF that are similar to changes reported in spontaneous migraine, but produces distinctly different effects on global CBF and velocity.

scholarly journals Reproducibility of Resting Cerebral Blood Flow Measurements with H215O Positron Emission Tomography in Humans

1993 ◽  
Vol 13 (5) ◽  
pp. 748-754 ◽  
Author(s):  
Elizabeth Matthew ◽  
Paul Andreason ◽  
Richard E. Carson ◽  
Peter Herscovitch ◽  
Karen Pettigrew ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regions Of Interest ◽  
Emission Tomography ◽  
Brain Blood Flow ◽  
Flow Measurements ◽  
Positron Emission ◽  
Normal Humans ◽  
Blood Flow Measurements

Two consecutive measurements of resting CBF were carried out in normal volunteers (n = 25) using H215O positron emission tomography. Absolute whole-brain blood flow (WBBF; ml 100 g−1 min−1, mean ± SD) for the first (40.3 ± 6.4) and second (39.3 ± 6.5) measurements was not significantly different (mean % difference 2.3 ± 8.7). Analysis of regions of interest showed no significant differences in absolute regional CBF (rCBF) and normalized (rCBF/WBBF) rCBF. Left-right differences were also not significant. These data demonstrate the reproducibility of resting CBF measurements in normal humans.

PET as Part of an Interdisciplinary Approach to Understanding Processes Involved in Reading

1993 ◽  
Vol 4 (5) ◽  
pp. 287-293 ◽  
Author(s):  
Julie A. Fiez ◽  
Steven E. Petersen
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Information Processing ◽  
Brain Activity ◽  
Interdisciplinary Approach ◽  
Emission Tomography ◽  
Brain Blood Flow ◽  
Positron Emission ◽  
Types Of Information ◽  
Task Conditions

Positron emission tomography (PET) is a recently developed technology that can be used to create images of brain blood flow, which is related to brain activity. By acquiring images of brain blood flow during different task conditions, investigators can isolate activity changes related to specific types of information processing. Several examples demonstrate how regions involved in reading can be identified, and how the results are most interpretable when information from other disciplines is considered.

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