Carcinoma of unknown primary in the inguinal lymph node region of squamous cell origin: A case series

2014 ◽  
Vol 4 (6) ◽  
pp. 404-408 ◽  
Author(s):  
Kurian Joseph ◽  
Michael B. Sawyer ◽  
John Amanie ◽  
Joseph Jones Thachuthara ◽  
Sunita Ghosh ◽  
...  
Keyword(s):  
Lymph Node ◽  
Squamous Cell ◽  
Inguinal Lymph Node ◽  
Case Series ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary

Inguinal Lymph Node Squamous Cell Carcinoma of Unknown Primary Site

2021 ◽  
Vol 32 (3) ◽  
pp. 411-414
Author(s):  
L Pina ◽  
D Sinagra ◽  
ME Paradedao ◽  
MA Juárez ◽  
F Muñoz Pozo
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Inguinal Lymph Node ◽  
Primary Site ◽  
Unknown Primary ◽  
Unknown Primary Site ◽  
Carcinoma Of Unknown Primary

Resumen El carcinoma escamoso de piel y mucosas presenta un riesgo potencial de metástasis ganglionares, con la posibilidad de que este suceso preceda la presentación clínica del tumor primario. El objetivo del presente trabajo es describir un caso de linfadenectomía inguinal por metástasis de carcinoma escamoso de origen primario desconocido y realizar una revisión bibliográfica de los casos presentados en la literatura médica. Se describió el caso de un hombre de 84 años con una tumoración inguinal correspondiente a una neoplasia escamosa, se le realizó una evaluación multidisciplinaria con dermatología, urología y coloproctología, sin encontrar el tumor primario. Se efectuó un vaciamiento inguinal con radioterapia postoperatoria. En la base de datos de Medline informaron solo 49 casos en los últimos 10 años. Las metástasis inguinales de carcinomas escamosos representan un grupo heterogéneo de neoplasias que pueden originarse a partir de la región anogenital o de territorios cutáneos de la zona perineal, miembros inferiores o parte baja del tronco. El manejo diagnóstico y terapéutico de estas lesiones continúa siendo un desafío al que se debe enfrentar con todas las herramientas disponibles y de forma multidisciplinaria.

scholarly journals A Case of Squamous Cell Carcinoma of Unknown Primary that Responded to the Multi-Tyrosine Kinase Inhibitor Lenvatinib

2018 ◽  
Vol 11 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Reiko Kimura-Tsuchiya ◽  
Eisaku Sasaki ◽  
Izumi Nakamura ◽  
Satoshi Suzuki ◽  
Satoshi Kawana ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Thyroid Cancer ◽  
Lymph Node ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Interstitial Pneumonia ◽  
Squamous Cell ◽  
Kinase Inhibitor ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary

Lenvatinib is an oral tyrosine kinase inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, fibroblast growth factor receptors 1 through 4, as well as platelet-derived growth factor receptor α, RET, and KIT. At present, lenvatinib is used in the treatment of thyroid cancer and renal cell carcinoma. We herein report a case of a 67-year-old patient with squamous cell carcinoma of unknown primary who was effectively treated with lenvatinib. The patient was initially diagnosed as having undifferentiated thyroid cancer, and after total thyroidectomy and bilateral lymph node dissection, lenvatinib was administered for the treatment of residual lymph node metastasis. A computed tomography scan after 1 month of lenvatinib administration showed marked regression of the lymph nodes, but interstitial pneumonia was also detected. Because the drug lymphocyte stimulation test for lenvatinib was strongly positive, we concluded that the interstitial pneumonia was induced by lenvatinib. The interstitial pneumonia only improved by the withdrawal of lenvatinib. Finally, his thyroid tumor was diagnosed as a metastasis of squamous cell carcinoma; however, we were unable to identify the primary lesion. This is the first reported case of interstitial pneumonia induced by lenvatinib.

Is CDX2 immunostaining useful for delineating anorectal from penile/vulvar squamous cancer in the setting of squamous cell carcinoma with clinically unknown primary site presenting with histologically confirmed inguinal lymph node metastasis?

2012 ◽  
Vol 66 (2) ◽  
pp. 109-112 ◽  
Author(s):  
Sven Gunia ◽  
Stefan Koch ◽  
Matthias May
Keyword(s):  
Lymph Node ◽  
High Risk ◽  
Lymph Node Metastasis ◽  
Squamous Cell ◽  
Inguinal Lymph Node ◽  
In Situ Hybridisation ◽  
Homeobox Gene ◽  
Unknown Primary ◽  
Inguinal Lymph Node Metastasis ◽  
Node Metastasis

AimsPenile, vulvar and anal squamous cell carcinomas (SCCs) share histomorphological overlap and are prone to lymphatic dissemination into inguinal nodes. Anal SCCs might derive from the anorectal zone (ARZ), anal transitional zone, squamous zone or from perianal skin. These anatomically distinct zones differ in terms of their embryological development. We sought to investigate the role of caudal-related homeobox 2 (CDX2), a homeobox gene implicated in the development and anterior/posterior pattern specification from duodenum to rectum including the ARZ, in terms of narrowing the possible sites of origin to be considered in the setting of SCC with unknown primary presenting with histologically confirmed inguinal lymph node metastasis.MethodsBy immunohistochemistry (IHC) employing a panel of antibodies directed against CK5/6, CK7, CK20, p63, p16, CEA and CDX2, we compared 89 penile, 11 vulvar and eight anal SCCs with respect to their staining profiles. Moreover, anal SCCs were subjected to in situ hybridisation (ISH) for high-risk human papillomavirus (HPV) subtypes.ResultsBy IHC, CDX2 expression was observed in 2/8 anal SCCs (25%) while being absent from all penile and vulvar SCCs examined. High-risk HPV subtypes were detected by ISH in all anal SCCs examined, which were uniformly p16-positive by IHC.ConclusionsCDX2 might be valuable in terms of narrowing the possible sites of origin to be considered in the setting of SCC with unknown primary presenting with inguinal lymph node metastasis. However, despite its favourable specificity, the diagnostic benefit achieved by this observation is limited by the low sensitivity.

Sign in / Sign up

Export Citation Format

Share Document