The role of adiposity in the relationship between serum leptin and severe major depressive episode

2015 ◽  
Vol 228 (3) ◽  
pp. 866-870 ◽  
Author(s):  
Chinedu C. Ubani ◽  
Jian Zhang
Keyword(s):  
Depressive Episode ◽  
Major Depressive Episode ◽  
Major Depressive ◽  
Serum Leptin ◽  
The Relationship

Empirical Investigation of Two Assumptions in the Diagnosis of DSM-IV Major Depressive Episode

2007 ◽  
Vol 41 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Chika Sakashita ◽  
Tim Slade ◽  
Gavin Andrews
Keyword(s):  
Depressive Episode ◽  
Major Depressive Episode ◽  
Sleep Problems ◽  
Composite International Diagnostic Interview ◽  
Population Based ◽  
Diagnostic Interview ◽  
Major Depressive ◽  
Diagnostic Threshold ◽  
Dsm Iv ◽  
The Relationship

Objective: The aim of the current study was to examine two major assumptions behind the DSM-IV diagnosis of major depressive episode (MDE): that depression represents a distinct category defined by a valid symptom threshold, and that each depressive symptom contributes equally to the diagnosis. Methods: Data were from the Australian National Survey of Mental Health and Wellbeing. Participants consisted of a random population-based sample of 10 641 community volunteers, representing a response rate of 78%. DSM-IV diagnoses of MDE and other mental disorders were obtained using the Composite International Diagnostic Interview, version 2.0. Analyses were carried out on the subsample of respondents who endorsed either depressed mood or loss of interest (n =2137). Multivariate linear regression analyses examined the relationship between the number and type of symptoms and four independent measures of impairment. Results: The relationship between the number of depressive symptoms and the four measures of impairment was purely linear. Three individual symptoms (sleep problems, energy loss, and psychomotor disturbance) were all independent predictors of three of the four measures of impairment. Conclusions: Counting symptoms alone is limited in guiding a clear diagnostic threshold. The differential impact of individual symptoms on impairment suggests that impairment levels may be more accurately estimated by weighting the particular symptoms endorsed.

scholarly journals Structural abnormalities associated with poor outcome of a major depressive episode: The role of thalamus

2020 ◽  
Vol 305 ◽  
pp. 111158
Author(s):  
JM. Batail ◽  
J. Coloigner ◽  
M. Soulas ◽  
G. Robert ◽  
C. Barillot ◽  
...  
Keyword(s):  
Depressive Episode ◽  
Major Depressive Episode ◽  
Major Depressive ◽  
Poor Outcome ◽  
Structural Abnormalities

scholarly journals Antidepressant-Resistant Depression and Antidepressant-Associated Suicidal Behaviour: The Role of Underlying Bipolarity

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Zoltan Rihmer ◽  
Xenia Gonda
Keyword(s):  
Depressive Episode ◽  
Suicidal Behaviour ◽  
Major Depressive Episode ◽  
Age At Onset ◽  
Early Age ◽  
Bipolar Spectrum ◽  
Clinical Markers ◽  
Major Depressive ◽  
Resistant Depression

The complex relationship between the use of antidepressants and suicidal behaviour is one of the hottest topics of our contemporary psychiatry. Based on the literature, this paper summarizes the author's view on antidepressant-resistant depression and antidepressant-associated suicidal behaviour. Antidepressant-resistance, antidepressant-induced worsening of depression, antidepressant-associated (hypo)manic switches, mixed depressive episode, and antidepressant-associated suicidality among depressed patients are relatively most frequent in bipolar/bipolar spectrum depression and in children and adolescents. As early age at onset of major depressive episode and mixed depression are powerful clinical markers of bipolarity and the manic component of bipolar disorder (and possible its biological background) shows a declining tendency with age antidepressant-resistance/worsening, antidepressant-induced (hypo)manic switches and “suicide-inducing” potential of antidepressants seem to be related to the underlying bipolarity.

scholarly journals INTERCONNECTION OF COGNITIVE DISORDERS AND CLINICAL AND PSYCHOPATOLOGICAL FEATURES IN PROLONGED DEPRESSIVE REACTION

2021 ◽  
Vol 2 (16) ◽  
pp. 39-47
Author(s):  
N.A. Maruta ◽  
S.A. Yaroslavtsev
Keyword(s):  
Depressive Episode ◽  
Depressive Disorders ◽  
Major Depressive Episode ◽  
Statistical Research ◽  
Major Depressive ◽  
Low Level ◽  
Remission Duration ◽  
Episode Duration ◽  
The Relationship ◽  
Depressive Reaction

Aim of research. The aim of the study was to determine the relationship between the clinical and psychopathological features of anxiety and depressive manifestations and the features of cognitive dysfunctions in patients with prolonged depressive reaction. Materials and methods. The study involved 98 patients with prolonged depressive reactions. The study used an integrated approach, which consisted in the use of clinical-psychopathological, psychometric, psychodiagnostic and statistical research methods. Results. According to the research results, a correlation analysis was carried out, which made it possible to determine the combination of clinical and psychopathological symptoms with the features of the cognitive functioning of patients with prolonged depressive reaction. Obsessive thoughts and hypochondriacal ideas have been shown to be associated with marked levels of anxiety; suicidal thoughts - with a protracted onset of depression and a minor depressive episode; mild violations of verbal productivity were associated with a major depressive episode and with a prolonged onset of depression, with 1-2 episodes of depression in anamnesis; a low level of attention switching was associated with an episode duration of up to 2 years, a protracted onset of depression, a major depressive episode, and an increased level of anxiety; average work efficiency correlated with a low level of anxiety, an episode duration of up to a year, 1-2 episodes of depression in anamnesis, a remission duration of more than 24 months; mobilization of mental processes was associated with a remission duration of more than 24 months and a reduced level of anxiety; high selectivity of attention to negative stimuli was combined with the duration of the episode up to 2 years and a pronounced level of anxiety; moderate disturbances in aggressive behavior patterns were associated with an episode duration of up to a year and a moderate level of anxiety. Conclusions. The relationship between clinical and psychopathological features of anxiety and depressive manifestations and features of cognitive dysfunction in patients with prolonged depressive reaction were identified. It should be considered in the differential diagnosis and in the development of psychocorrective measures to reduce cognitive impairment in patients with depressive disorders.

scholarly journals INTERCONNECTION OF COGNITIVE DISORDERS AND CLINICAL AND PSYCHOPATOLOGICAL FEATURES IN PATIENTS WITH PROLONGED DEPRESSIVE REACTION

2020 ◽  
Vol 4 (14) ◽  
pp. 52-61
Author(s):  
N.A. Maruta ◽  
S.A. Yaroslavtsev
Keyword(s):  
Depressive Episode ◽  
Depressive Disorders ◽  
Major Depressive Episode ◽  
Statistical Research ◽  
Major Depressive ◽  
Low Level ◽  
Remission Duration ◽  
Episode Duration ◽  
The Relationship ◽  
Depressive Reaction

Aim: to determine the relationship between the clinical and psychopathological features of anxiety and depressive manifestations and the features of cognitive dysfunctions in patients with prolonged depressive reaction. Material and methods. The study enrolled 98 patients with prolonged depressive reactions. The study used an integrated approach, which consisted in the use of clinical-psychopathological, psychometric, psychodiagnostic and statistical research methods. Results. According to the research results, a correlation analysis was carried out, which made it possible to determine the combination of clinical and psychopathological symptoms with the features of the cognitive functioning of patients with prolonged depressive reaction. Obsessive thoughts and hypochondriacal ideas have been shown to be associated with marked levels of anxiety; suicidal thoughts – with a protracted onset of depression and a minor depressive episode; mild violations of verbal productivity were associated with a major depressive episode and with a prolonged onset of depression, with 1-2 episodes of depression in anamnesis; a low level of attention switching was associated with an episode duration of up to 2 years, a protracted onset of depression, a major depressive episode, and an increased level of anxiety; average work efficiency correlated with a low level of anxiety, an episode duration of up to a year, 1-2 episodes of depression in anamnesis, a remission duration of more than 24 months; mobilization of mental processes was associated with a remission duration of more than 24 months and a reduced level of anxiety; high selectivity of attention to negative stimuli was combined with the duration of the episode up to 2 years and a pronounced level of anxiety; moderate disturbances in aggressive behavior patterns were associated with an episode duration of up to a year and a moderate level of anxiety. Conclusions. The relationship between clinical and psychopathological features of anxiety and depressive manifestations and features of cognitive dysfunction in patients with prolonged depressive reaction were identified. It should be considered in the differential diagnosis and in the development of psychocorrective measures to reduce cognitive impairment in patients with depressive disorders.

scholarly journals The role of different patterns of psychomotor symptoms in major depressive episode: Pooled analysis of the BRIDGE and BRIDGE‐II‐MIX cohorts

2019 ◽  
Vol 21 (8) ◽  
pp. 785-793 ◽  
Author(s):  
Margherita Barbuti ◽  
Cecilia Mainardi ◽  
Isabella Pacchiarotti ◽  
Norma Verdolini ◽  
Giuseppe Maccariello ◽  
...  
Keyword(s):  
Depressive Episode ◽  
Major Depressive Episode ◽  
Pooled Analysis ◽  
Major Depressive ◽  
Psychomotor Symptoms
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