Inducing a stressed phenotype in healthy recipient mice by adoptively transferring CD4+ lymphocytes from mice undergoing chronic psychosocial stress

2020 ◽  
Vol 122 ◽  
pp. 104898
Author(s):  
Mattia Amoroso ◽  
Elena Kempter ◽  
Dominik Langgartner ◽  
Philipp Gross ◽  
Stefan O. Reber
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Guy A. Prochilo ◽  
Ricardo J.S. Costa ◽  
Craig Hassed ◽  
Richard Chambers ◽  
Pascal Molenberghs

Abstract Objectives Researchers have begun delivering mindfulness and aerobic exercise training concurrently on the premise that a combination intervention will yield salutary outcomes over and above each intervention alone. An estimate of the effect of combination training on chronic psychosocial stress in a nonclinical population has not been established. The objective of this study was to establish protocol feasibility in preparation of a definitive RCT targeting healthy individuals, and to explore the preliminary effect of combination training on reducing chronic psychosocial stress in this population. Methods Twenty-four participants were allocated to a single-arm pre-post study and subjected to 16 weeks of concurrent mindfulness psychoeducation and aerobic exercise training. Feasibility criteria were collected and evaluated. Within-group changes in chronic psychosocial stress, mindfulness, emotion regulation, and cardiorespiratory fitness were also assessed. Primary analyses were based on 17 participants. Results Retention rate, response rate, recruitment rate, and sample size analyses indicate a definitive trial is feasible for detecting most effects with precision. There was also a decline in our primary dependent measure of chronic psychosocial stress (dpretest = −0.56, 95% CI [ −1.14,−0.06]). With regard to secondary measures, there was an increase in the use of cognitive reappraisal, and a reduction in use of maladaptive emotion regulation strategies. We are insufficiently confident to comment on changes in mindfulness and aerobic capacity $\left (\dot {V}O_{2max}\right)$ V ̇ O 2 max . However, there were subgroup improvements in aerobic economy at submaximal exercise intensities. Conclusions We recommend a definitive trial is feasible and should proceed. Trial registration ANZCTR (ID: ACTRN12619001726145). Retrospectively registered December 9, 2019.


2016 ◽  
Vol 32 (5) ◽  
pp. 235-240
Author(s):  
Ana Starcevic ◽  
Sasa Petricevic ◽  
Zoran Radojicic ◽  
Vuk Djulejic ◽  
Andrej Ilankovic ◽  
...  

NeuroImage ◽  
2016 ◽  
Vol 142 ◽  
pp. 544-552 ◽  
Author(s):  
Joanes Grandjean ◽  
Damiano Azzinnari ◽  
Aline Seuwen ◽  
Hannes Sigrist ◽  
Erich Seifritz ◽  
...  

2012 ◽  
Vol 37 (10) ◽  
pp. 1676-1687 ◽  
Author(s):  
Nicole Uschold-Schmidt ◽  
Kewir D. Nyuyki ◽  
Andrea M. Füchsl ◽  
Inga D. Neumann ◽  
Stefan O. Reber

2016 ◽  
Vol 63 ◽  
pp. 217-227 ◽  
Author(s):  
Aadil Bharwani ◽  
M. Firoz Mian ◽  
Jane A. Foster ◽  
Michael G. Surette ◽  
John Bienenstock ◽  
...  

2020 ◽  
Vol Volume 14 ◽  
pp. 5299-5314
Author(s):  
Karem H Alzoubi ◽  
Laila Abdel-Hafiz ◽  
Omar F Khabour ◽  
Tamam El-Elimat ◽  
Mohammad A Alzubi ◽  
...  

2010 ◽  
Vol 35 (1) ◽  
pp. 115-121 ◽  
Author(s):  
Alexander Hänsel ◽  
Suzi Hong ◽  
Rafael J.A. Cámara ◽  
Roland von Känel

Sign in / Sign up

Export Citation Format

Share Document