Age-dependent susceptibility of adult hippocampal cell proliferation to chronic psychosocial stress

2005 ◽  
Vol 1049 (2) ◽  
pp. 244-248 ◽  
Author(s):  
Mária Simon ◽  
Boldizsár Czéh ◽  
Eberhard Fuchs
2009 ◽  
Vol 29 (3) ◽  
pp. 635-640 ◽  
Author(s):  
Muriel Koehl ◽  
Valerie Lemaire ◽  
Michel Le Moal ◽  
Djoher N. Abrous

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Guy A. Prochilo ◽  
Ricardo J.S. Costa ◽  
Craig Hassed ◽  
Richard Chambers ◽  
Pascal Molenberghs

Abstract Objectives Researchers have begun delivering mindfulness and aerobic exercise training concurrently on the premise that a combination intervention will yield salutary outcomes over and above each intervention alone. An estimate of the effect of combination training on chronic psychosocial stress in a nonclinical population has not been established. The objective of this study was to establish protocol feasibility in preparation of a definitive RCT targeting healthy individuals, and to explore the preliminary effect of combination training on reducing chronic psychosocial stress in this population. Methods Twenty-four participants were allocated to a single-arm pre-post study and subjected to 16 weeks of concurrent mindfulness psychoeducation and aerobic exercise training. Feasibility criteria were collected and evaluated. Within-group changes in chronic psychosocial stress, mindfulness, emotion regulation, and cardiorespiratory fitness were also assessed. Primary analyses were based on 17 participants. Results Retention rate, response rate, recruitment rate, and sample size analyses indicate a definitive trial is feasible for detecting most effects with precision. There was also a decline in our primary dependent measure of chronic psychosocial stress (dpretest = −0.56, 95% CI [ −1.14,−0.06]). With regard to secondary measures, there was an increase in the use of cognitive reappraisal, and a reduction in use of maladaptive emotion regulation strategies. We are insufficiently confident to comment on changes in mindfulness and aerobic capacity $\left (\dot {V}O_{2max}\right)$ V ̇ O 2 max . However, there were subgroup improvements in aerobic economy at submaximal exercise intensities. Conclusions We recommend a definitive trial is feasible and should proceed. Trial registration ANZCTR (ID: ACTRN12619001726145). Retrospectively registered December 9, 2019.


2016 ◽  
Vol 32 (5) ◽  
pp. 235-240
Author(s):  
Ana Starcevic ◽  
Sasa Petricevic ◽  
Zoran Radojicic ◽  
Vuk Djulejic ◽  
Andrej Ilankovic ◽  
...  

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Marco Benevento ◽  
Charlotte A. Oomen ◽  
Alexa E. Horner ◽  
Houshang Amiri ◽  
Tessa Jacobs ◽  
...  

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Aleah Holmes ◽  
Yan Xu ◽  
Juneyoung Lee ◽  
Liang Zhu ◽  
Venugopal Reddy Venna ◽  
...  

Background: Social isolation (SI) and loneliness are risk factors for stroke. Epidemiological studies have shown that women tend to have a higher risk of stroke at later age and elderly women are more likely to be isolated. The mechanisms underlying the detrimental effects of SI have not been well studied in older females. We hypothesized that SI in aged female mice would lead to impaired post-stroke recovery and could lead to differential regulation of microRNAs (miRNAs). Methods: In this study, aged C57BL/6N female mice were subjected to a 60-minute middle cerebral artery occlusion (MCAO) and were randomly assigned to either single housing (SI) or continued pair housing (PH) immediately after stroke for 15 days. Infarct size, mortality and recovery was assessed using open field, the adhesive-tape removal task and the Y-maze test. MiRNAs were comprehensively analyzed by miRNAome analysis on stroke brain, and changes in hippocampal cell proliferation was assessed from perfused brain sections. Results: Importantly, SI immediately after stroke led to significantly larger tissue loss and higher mortality in aged females, it also significantly delayed motor/sensory recovery in the adhesive removal test and impaired overall locomotor activity. In addition, these mice also demonstrated worse post-stroke cognitive function. In parallel, brains of these mice showed reduced miR-297a-3p expression and increased miR-18a-3p and miR-200c-3p expression with SI compared to PH cohort and reduced hippocampal cell proliferation. Conclusion: The results from this study suggest that SI after stroke can increase mortality and significantly impair post-stroke recovery in aged female mice. These worse outcomes are in parallel to the significant changes in several miRNAs and reduced hippocampal cell proliferation.


NeuroImage ◽  
2016 ◽  
Vol 142 ◽  
pp. 544-552 ◽  
Author(s):  
Joanes Grandjean ◽  
Damiano Azzinnari ◽  
Aline Seuwen ◽  
Hannes Sigrist ◽  
Erich Seifritz ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document