The added value of a portable gamma camera for intraoperative detection of sentinel lymph node in squamous cell carcinoma of the oral cavity: A case report

Abstract Background Near-Infrared (NIR) fluorescence imaging is a novel technique for intraoperative sentinel lymph node (SLN) identification. It has demonstrated promising results in several surgical specialties. The study aims to evaluate the feasibility of identifying the SLN by indocyanine green (ICG) enhanced NIR endoscopy in squamous cell carcinoma of the oral cavity (OCSCC). Methods Five patients with (cT1-3N0) OCSCC were included. We injected 1–1.25 ml of ICG (5 mg/ml) at four to five points around the primary. After the elevation of a platysma flap and posterior retraction of the sternocleidomastoid muscle, fluorescence images were taken with the IMAGE1 S™ NIR/ICG system to define the SLN(s). We sampled fluorescence marked SLN(s) stratified to lymph node levels, followed by level-specified elective neck dissection. Results The detection of at least one uni- or bilateral SLN (range 1–4) was possible in every case. The fluorescence signal occurred, on average, 4.8 ± 2.6 minutes after injection. There was no case of neck metastasis in SLN (0/13) and non-SLN (0/189). No adverse reactions to ICG occurred. Conclusions Our first results are confirming the concept of SLN concerning OCSCC after the application of real-time NIR fluorescence endoscopy. However, this has to be verified by more extended studies.

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Feasibility of sentinel lymph node detection by near-infrared endoscopy in squamous cell carcinoma of the oral cavity

10.1055/s-0041-1727922 ◽

2021 ◽

Author(s):

M Sievert ◽

S Müller ◽

A-O Gostian ◽

H Iro ◽

M Koch

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Near Infrared ◽

Sentinel Lymph Node Detection

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Sentinel lymph node biopsy as an alternative to wait and see policy in patients with small T1 oral cavity squamous cell carcinoma

Acta Oto-Laryngologica ◽

10.1080/00016480701362002 ◽

2008 ◽

Vol 128 (1) ◽

pp. 98-102 ◽

Cited By ~ 13

Author(s):

>Harri Keski-säntti ◽

Risto Kontio ◽

Ilmo Leivo ◽

Jyrki Törnwall ◽

Sorjo Mätzke ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Sentinel Lymph Node Biopsy ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Lymph Node Biopsy ◽

Node Biopsy ◽

Wait And See

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Sentinel lymph node biopsy in node-negative squamous cell carcinoma of the oral cavity and oropharynx

The Journal of Laryngology & Otology ◽

10.1017/s0022215108003514 ◽

2008 ◽

Vol 123 (4) ◽

pp. 439-443 ◽

Cited By ~ 8

Author(s):

P Burns ◽

A Foster ◽

P Walshe ◽

T O'Dwyer

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Sentinel Lymph Node Biopsy ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Lymph Node Biopsy ◽

Oropharyngeal Squamous Cell Carcinoma ◽

Node Negative

AbstractObjectives:Considerable controversy exists regarding the merits of elective neck dissection in patients with early stage oral cavity and oropharyngeal squamous cell carcinoma. It is highly desirable to have a method of identifying those patients who would benefit from further treatment of the neck when they are clinically node-negative. The purpose of the present study was to examine the use of sentinel lymph node biopsy in identifying occult neck disease in a cohort of patients with node-negative oral cavity and oropharyngeal squamous cell carcinoma.Design:We evaluated a total of 13 patients with oral cavity and oropharyngeal cancer who were clinically and radiologically node-negative.Results:A sentinel lymph node was found in all 13 patients, revealing metastatic disease in five patients, four of whom had one or more positive sentinel lymph nodes. There was one false negative result, in which the sentinel lymph node was negative for tumour whereas histological examination of the neck dissection specimen showed occult disease.Conclusion:In view of these findings, we would recommend the use of sentinel lymph node biopsy in cases of oral cavity and oropharyngeal squamous cell carcinoma, in order to aid the differentiation of those patients whose necks are harbouring occult disease and who require further treatment.

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