scholarly journals Feasibility of sentinel lymph node detection by near-infrared endoscopy in squamous cell carcinoma of the oral cavity: a pilot study

2020 ◽  
Author(s):  
Matti Sievert ◽  
Miguel Goncalves ◽  
Markus Eckstein ◽  
Heinrich Iro ◽  
Michael Koch
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Near Infrared ◽  
Elective Neck Dissection ◽  
Fluorescence Signal ◽  
Nir Fluorescence

Abstract Background Near-Infrared (NIR) fluorescence imaging is a novel technique for intraoperative sentinel lymph node (SLN) identification. It has demonstrated promising results in several surgical specialties. The study aims to evaluate the feasibility of identifying the SLN by indocyanine green (ICG) enhanced NIR endoscopy in squamous cell carcinoma of the oral cavity (OCSCC). Methods Five patients with (cT1-3N0) OCSCC were included. We injected 1–1.25 ml of ICG (5 mg/ml) at four to five points around the primary. After the elevation of a platysma flap and posterior retraction of the sternocleidomastoid muscle, fluorescence images were taken with the IMAGE1 S™ NIR/ICG system to define the SLN(s). We sampled fluorescence marked SLN(s) stratified to lymph node levels, followed by level-specified elective neck dissection. Results The detection of at least one uni- or bilateral SLN (range 1–4) was possible in every case. The fluorescence signal occurred, on average, 4.8 ± 2.6 minutes after injection. There was no case of neck metastasis in SLN (0/13) and non-SLN (0/189). No adverse reactions to ICG occurred. Conclusions Our first results are confirming the concept of SLN concerning OCSCC after the application of real-time NIR fluorescence endoscopy. However, this has to be verified by more extended studies.

scholarly journals Sentinel Lymph Node Biopsy for Early Oral Cavity Squamous Cell Carcinoma

2021 ◽  
Author(s):  
Rajith Mendis ◽  
Muzib Abdul-Razak
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Lymph Node Biopsy ◽  
Elective Neck Dissection

Early stage oral cavity squamous cell carcinoma (OCSCC) has a significant risk of subclinical nodal metastases, which is the strongest independent prognostic factor for regional recurrence and survival. However current preoperative imaging modalities are unable to identify patients with micrometastases, and an observation strategy has been associated with inferior outcomes when compared to an elective neck dissection. Sentinel lymph node biopsy provides a safe and accurate staging procedure to select the patients who benefit from an elective neck dissection, while avoiding unnecessary surgery in the patients who are node negative. There is recent Level II evidence demonstrating equivalent oncological outcomes when compared with elective neck dissection. However, a multidisciplinary approach is required including reliable mapping of the sentinel lymph node, precise surgical technique and comprehensive histopathological analysis to ensure accurate results are obtained.

The Role of Sentinel Lymph Node Biopsy in Oral Cavity Squamous Cell Carcinoma

2019 ◽  
Vol 85 (11) ◽  
pp. 549-552
Author(s):  
Anna Lazutkin ◽  
Ron Eliashar ◽  
Jawad Abu-Tair ◽  
Jeffrey M. Weinberger ◽  
Nir Hirshoren
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymph Node Biopsy ◽  
Node Biopsy

Sentinel lymph node biopsy as an alternative to wait and see policy in patients with small T1 oral cavity squamous cell carcinoma

2008 ◽  
Vol 128 (1) ◽  
pp. 98-102 ◽  
Author(s):  
>Harri Keski-säntti ◽  
Risto Kontio ◽  
Ilmo Leivo ◽  
Jyrki Törnwall ◽  
Sorjo Mätzke ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Wait And See

Sentinel lymph node biopsy in node-negative squamous cell carcinoma of the oral cavity and oropharynx

2008 ◽  
Vol 123 (4) ◽  
pp. 439-443 ◽  
Author(s):  
P Burns ◽  
A Foster ◽  
P Walshe ◽  
T O'Dwyer
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymph Node Biopsy ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Node Negative

AbstractObjectives:Considerable controversy exists regarding the merits of elective neck dissection in patients with early stage oral cavity and oropharyngeal squamous cell carcinoma. It is highly desirable to have a method of identifying those patients who would benefit from further treatment of the neck when they are clinically node-negative. The purpose of the present study was to examine the use of sentinel lymph node biopsy in identifying occult neck disease in a cohort of patients with node-negative oral cavity and oropharyngeal squamous cell carcinoma.Design:We evaluated a total of 13 patients with oral cavity and oropharyngeal cancer who were clinically and radiologically node-negative.Results:A sentinel lymph node was found in all 13 patients, revealing metastatic disease in five patients, four of whom had one or more positive sentinel lymph nodes. There was one false negative result, in which the sentinel lymph node was negative for tumour whereas histological examination of the neck dissection specimen showed occult disease.Conclusion:In view of these findings, we would recommend the use of sentinel lymph node biopsy in cases of oral cavity and oropharyngeal squamous cell carcinoma, in order to aid the differentiation of those patients whose necks are harbouring occult disease and who require further treatment.

scholarly journals Sentinel Lymph Node Biopsy in N0 Squamous Cell Carcinoma of the Oral Cavity and Oropharynx

2005 ◽  
Vol 131 (1) ◽  
pp. 34 ◽  
Author(s):  
Robert D. Hart ◽  
Joseph G. Nasser ◽  
Jonathan R. Trites ◽  
S. Mark Taylor ◽  
Martin Bullock ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymph Node Biopsy ◽  
Node Biopsy

scholarly journals The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma

2018 ◽  
Vol 46 (3) ◽  
pp. 623-637 ◽  
Author(s):  
Francesco Giammarile ◽  
Clare Schilling ◽  
Gopinanth Gnanasegaran ◽  
Chandrasckhar Bal ◽  
Wim J. G. Oyen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Practical Guidelines
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