Abstract
Background
In Egypt, Aluminium phosphide (ALP) poisoning is a major cause of suicidal deaths. Nevertheless, no efficient antidote has been found so far. Intravenous lipid emulsion (ILE) has been successfully used in resuscitation of two ALP-poisoned patients.
Aim
was to evaluate efficacy and safety of ILE as an adjuvant therapy of acute ALP poisoning.
Methods
ALP-poisoned patients were recruited from Tanta University Poison Control center. Eligible patients were randomly allocated into experimental and control groups (25 patients each). Patients in the experimental group have received ILE 20% at a rate of 10ml/h continuous IV infusion, in addition to the standard treatment. Whereas, the control group have only administered the standard treatment.
Results
The mortality rate in the experimental group was non-significantly lower than the control group (56% versus 76% respectively). The need for intubation and mechanical ventilation was significantly lower in the experimental group compared to the control group (36% versus 92% respectively). Moreover, the median length of hospital stay was significantly lower in survivors of the experimental group.
Conclusion
Adjuvant ILE use along with the supportive treatment could have a therapeutic effect in ALP poisoned patients. Additionally, it was an overall safe therapy.
Assessment of Intravenous Lipid Emulsion as an Adjuvant Therapy in Acute Aluminum Phosphide Poisoning: A randomized Controlled Trial
