Étude de l’impact des différents anti-TNF sur les structures granulomateuses : rôle du reverse signaling du TNF transmembranaire

2021 ◽  
Vol 88 ◽  
pp. A77
Author(s):  
D. Caillet Portillo ◽  
Y. Degboe ◽  
K. Diallo ◽  
M. Baron ◽  
A. Ruyssen-Witrand ◽  
...  
Keyword(s):  
Reverse Signaling

scholarly journals Attenuation of EphrinB2 Reverse Signaling Decreases Vascularized Area and Preretinal Vascular Tuft Formation in the Murine Model of Oxygen-Induced Retinopathy

2012 ◽  
Vol 53 (9) ◽  
pp. 5462 ◽  
Author(s):  
Alyssa C. Taylor ◽  
Thomas A. Mendel ◽  
Katelyn E. Mason ◽  
Katherine E. Degen ◽  
Paul A. Yates ◽  
...  
Keyword(s):  
Murine Model ◽  
Reverse Signaling ◽  
Oxygen Induced Retinopathy

scholarly journals A dual role of EphB1/ephrin-B3 reverse signaling on migrating striatal and cortical neurons originating in the preoptic area: should I stay or go away?

2014 ◽  
Vol 8 ◽  
Author(s):  
Judith Rudolph ◽  
Katrin Gerstmann ◽  
Geraldine Zimmer ◽  
André Steinecke ◽  
Annika Döding ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Preoptic Area ◽  
Dual Role ◽  
Reverse Signaling

scholarly journals Proinflammatory Soluble Interleukin-15 Receptor Alpha Is Increased in Rheumatoid Arthritis

Arthritis ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Ana Cecilia Machado Diaz ◽  
Araceli Chico Capote ◽  
Celia Aurora Arrieta Aguero ◽  
Yunier Rodríguez Alvarez ◽  
Diana García del Barco Herrera ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Fluid ◽  
Enzyme Linked Immunosorbent Assay ◽  
Reverse Signaling ◽  
Synovial Fluids ◽  
Inflammatory Processes ◽  
Membrane Bound ◽  
Interleukin 15 ◽  
Interleukin 15 Receptor Alpha ◽  
Pro Inflammatory Cytokines

Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease in which many cytokines have been implicated. In particular, IL-15 is a cytokine involved in the inflammatory processes and bone loss. The aim of this study was to investigate the existence in synovial fluid of soluble IL-15Rα, a private receptor subunit for IL-15 which may act as an enhancer of IL-15-induced proinflammatory cytokines. Soluble IL-15Rα was quantified by a newly developed enzyme-linked immunosorbent assay (ELISA) in samples of synovial fluid from patients with RA and osteoarthritis (OA). The levels of IL-15Rα were significantly increased in RA patients compared to OA patients. Also, we studied the presence of membrane-bound IL-15 in cells from synovial fluids, another element necessary to induce pro-inflammatory cytokines through reverse signaling. Interestingly, we found high levels of IL-6 related to high levels of IL-15Rα in RA but not in OA. Thus, our results evidenced presence of IL-15Rα in synovial fluids and suggested that its pro-inflammatory effect could be related to induction of IL-6.

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