Novel effects of identified SNPs within the porcine Pregnancy-Associated Glycoprotein gene family ( pPAGs ) on the major reproductive traits in Hirschmann hybrid-line sows

2017 ◽  
Vol 114 ◽  
pp. 123-130 ◽  
Author(s):  
Grzegorz Panasiewicz ◽  
Martyna Bieniek-Kobuszewska ◽  
Aleksandra Lipka ◽  
Marta Majewska ◽  
Roman Jedryczko ◽  
...  
Keyword(s):  
Gene Family ◽  
Reproductive Traits ◽  
Hybrid Line ◽  
Glycoprotein Gene

scholarly journals Identification of members of the P-glycoprotein multigene family.

1989 ◽  
Vol 9 (3) ◽  
pp. 1224-1232 ◽  
Author(s):  
W F Ng ◽  
F Sarangi ◽  
R L Zastawny ◽  
L Veinot-Drebot ◽  
V Ling
Keyword(s):  
Multidrug Resistance ◽  
Gene Duplication ◽  
Gene Family ◽  
Multigene Family ◽  
Rhesus Monkeys ◽  
Genomic Library ◽  
Duplication Event ◽  
Glycoprotein Gene ◽  
P Glycoprotein ◽  
Exon Probe

Overproduction of P-glycoprotein is intimately associated with multidrug resistance. This protein appears to be encoded by a multigene family. Thus, differential expression of different members of this family may contribute to the complexity of the multidrug resistance phenotype. Three lambda genomic clones isolated from a hamster genomic library represent different members of the hamster P-glycoprotein gene family. Using a highly conserved exon probe, we found that the hamster P-glycoprotein gene family consists of three genes. We also found that the P-glycoprotein gene family consists of three genes in mice but has only two genes in humans and rhesus monkeys. The hamster P-glycoprotein genes have similar exon-intron organizations within the 3' region encoding the cytoplasmic domains. We propose that the hamster P-glycoprotein gene family arose from gene duplication. The hamster pgp1 and pgp2 genes appear to be more closely related to each other than either gene is to the pgp3 gene. We speculate that the hamster pgp1 and pgp2 genes arose from a recent gene duplication event and that primates did not undergo this duplication and therefore contain only two P-glycoprotein genes.

scholarly journals Small Integrin Binding Ligand N-Linked Glycoprotein Gene Family Expression in Different Cancers

2004 ◽  
Vol 10 (24) ◽  
pp. 8501-8511 ◽  
Author(s):  
Larry W. Fisher ◽  
Alka Jain ◽  
Matt Tayback ◽  
Neal S. Fedarko
Keyword(s):  
Gene Family ◽  
Glycoprotein Gene

Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas

1994 ◽  
Vol 223 (2) ◽  
pp. 529-541 ◽  
Author(s):  
Wendy HAUCK ◽  
Patrick NEDELLEC ◽  
Claire TURBIDE ◽  
Clifford P. STANNERS ◽  
Thomas R. BARNETT ◽  
...  
Keyword(s):  
Gene Family ◽  
Family Member ◽  
Transcriptional Control ◽  
Colorectal Carcinomas ◽  
Glycoprotein Gene ◽  
Gene Family Member ◽  
Cea Gene

scholarly journals Structure and expression of the human MDR (P-glycoprotein) gene family.

1989 ◽  
Vol 9 (9) ◽  
pp. 3808-3820 ◽  
Author(s):  
J E Chin ◽  
R Soffir ◽  
K E Noonan ◽  
K Choi ◽  
I B Roninson
Keyword(s):  
Gene Family ◽  
Cell Lines ◽  
Efflux Pump ◽  
Expression Patterns ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
Mdr1 Gene ◽  
Glycoprotein Gene ◽  
P Glycoprotein ◽  
Mdr Genes

The human MDR (P-glycoprotein) gene family is known to include two members, MDR1 and MDR2. The product of the MDR1 gene, which is responsible for resistance to different cytotoxic drugs (multidrug resistance), appears to serve as an energy-dependent efflux pump for various lipophilic compounds. The function of the MDR2 gene remains unknown. We have examined the structure of the human MDR gene family by Southern hybridization of DNA from different multidrug-resistant cell lines with subfragments of MDR1 cDNA and by cloning and sequencing of genomic fragments. We have found no evidence for any other cross-hybridizing MDR genes. The sequence of two exons of the MDR2 gene was determined from genomic clones. Hybridization with single-exon probes showed that the human MDR1 gene is closely related to two genes in mouse and hamster DNA, whereas MDR2 corresponds to one rodent gene. The human MDR locus was mapped by field-inversion gel electrophoresis, and both MDR genes were found to be linked within 330 kilobases. The expression patterns of the human MDR genes were examined by enzymatic amplification of cDNA. In multidrug-resistant cell lines, increased expression of MDR1 mRNA was paralleled by a smaller increase in the levels of MDR2 mRNA. In normal human tissues, MDR2 was coexpressed with MDR1 in the liver, kidney, adrenal gland, and spleen. MDR1 expression was also detected in colon, lung, stomach, esophagus, muscle, breast, and bladder.

Chromosomal assignment of porcine pregnancy-associated glycoprotein gene family

2010 ◽  
Vol 117 (1-2) ◽  
pp. 127-134 ◽  
Author(s):  
M. Majewska ◽  
G. Panasiewicz ◽  
B. Szafranska
Keyword(s):  
Gene Family ◽  
Chromosomal Assignment ◽  
Glycoprotein Gene

Structure and expression of the human MDR (P-glycoprotein) gene family

1989 ◽  
Vol 9 (9) ◽  
pp. 3808-3820
Author(s):  
J E Chin ◽  
R Soffir ◽  
K E Noonan ◽  
K Choi ◽  
I B Roninson
Keyword(s):  
Gene Family ◽  
Cell Lines ◽  
Efflux Pump ◽  
Expression Patterns ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
Mdr1 Gene ◽  
Glycoprotein Gene ◽  
P Glycoprotein ◽  
Mdr Genes

The human MDR (P-glycoprotein) gene family is known to include two members, MDR1 and MDR2. The product of the MDR1 gene, which is responsible for resistance to different cytotoxic drugs (multidrug resistance), appears to serve as an energy-dependent efflux pump for various lipophilic compounds. The function of the MDR2 gene remains unknown. We have examined the structure of the human MDR gene family by Southern hybridization of DNA from different multidrug-resistant cell lines with subfragments of MDR1 cDNA and by cloning and sequencing of genomic fragments. We have found no evidence for any other cross-hybridizing MDR genes. The sequence of two exons of the MDR2 gene was determined from genomic clones. Hybridization with single-exon probes showed that the human MDR1 gene is closely related to two genes in mouse and hamster DNA, whereas MDR2 corresponds to one rodent gene. The human MDR locus was mapped by field-inversion gel electrophoresis, and both MDR genes were found to be linked within 330 kilobases. The expression patterns of the human MDR genes were examined by enzymatic amplification of cDNA. In multidrug-resistant cell lines, increased expression of MDR1 mRNA was paralleled by a smaller increase in the levels of MDR2 mRNA. In normal human tissues, MDR2 was coexpressed with MDR1 in the liver, kidney, adrenal gland, and spleen. MDR1 expression was also detected in colon, lung, stomach, esophagus, muscle, breast, and bladder.

Identification of members of the P-glycoprotein multigene family

1989 ◽  
Vol 9 (3) ◽  
pp. 1224-1232
Author(s):  
W F Ng ◽  
F Sarangi ◽  
R L Zastawny ◽  
L Veinot-Drebot ◽  
V Ling
Keyword(s):  
Multidrug Resistance ◽  
Gene Duplication ◽  
Gene Family ◽  
Multigene Family ◽  
Rhesus Monkeys ◽  
Genomic Library ◽  
Duplication Event ◽  
Glycoprotein Gene ◽  
P Glycoprotein ◽  
Exon Probe

Overproduction of P-glycoprotein is intimately associated with multidrug resistance. This protein appears to be encoded by a multigene family. Thus, differential expression of different members of this family may contribute to the complexity of the multidrug resistance phenotype. Three lambda genomic clones isolated from a hamster genomic library represent different members of the hamster P-glycoprotein gene family. Using a highly conserved exon probe, we found that the hamster P-glycoprotein gene family consists of three genes. We also found that the P-glycoprotein gene family consists of three genes in mice but has only two genes in humans and rhesus monkeys. The hamster P-glycoprotein genes have similar exon-intron organizations within the 3' region encoding the cytoplasmic domains. We propose that the hamster P-glycoprotein gene family arose from gene duplication. The hamster pgp1 and pgp2 genes appear to be more closely related to each other than either gene is to the pgp3 gene. We speculate that the hamster pgp1 and pgp2 genes arose from a recent gene duplication event and that primates did not undergo this duplication and therefore contain only two P-glycoprotein genes.

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