Corrigendum to “Synthesis, spectral characterization, molecular modeling and in vitro antibacterial activity of complexes designed from OO, NO and NN donor Schiff-base ligand” [Spectrochim. Acta Part A 135 (2015) 227–240]

A synthetic approach has been designed and followed for the synthesis of new bidentate Schiff base ligand 2-acetylthiophenenicotinic hydrazone (L) (which possessed nitrogen and oxygen donor atoms) and its Co(II) and Cu(II) mononuclear complexes. All the compounds were examined IR, 1H NMR, mass, EPR, conductivity, elemental analysis, etc. Octahedral geometry has been assigned to all synthesized compounds on the basis of magnetic, IR and electronic spectral analysis. In vitro activity i.e. antibacterial (E. coli and P. aeruginosa) and antifungal (A. niger, M. phasolina and P. glomerata) had been examined for these compounds following well diffusion and poisoned food methods, respectively. During the performance of antifungal activity, antifungal agent was incorporated into the molten agar at various concentrations and mixed well. After performance of in vitro activity, it has been resulted out that metal(II) complexes exhibited remarkable activity than free ligand but less active compared to the standard drugs..

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Transition Metal(II) Complexes with Cefotaxime-Derived Schiff Base: Synthesis, Characterization, and Antimicrobial Studies

Bioinorganic Chemistry and Applications ◽

10.1155/2014/926287 ◽

2014 ◽

Vol 2014 ◽

pp. 1-17 ◽

Cited By ~ 11

Author(s):

Aurora Reiss ◽

Mariana Carmen Chifiriuc ◽

Emilia Amzoiu ◽

Cezar Ionuţ Spînu

Keyword(s):

Antibacterial Activity ◽

Schiff Base ◽

Schiff Base Ligand ◽

Magnetic Measurements ◽

Magnetic Moments ◽

Chemical Properties ◽

Molar Conductance ◽

Bacterial Strains ◽

Vis Spectroscopy

New [ML2(H2O)2] complexes, where M = Co(II), Ni(II), Cu(II), and Zn(II) while L corresponds to the Schiff base ligand, were synthesized by condensation of cefotaxime with salicylaldehydein situin the presence of divalent metal salts in ethanolic medium. The complexes were characterized by elemental analyses, conductance, and magnetic measurements, as well as by IR and UV-Vis spectroscopy. The low values of the molar conductance indicate nonelectrolyte type of complexes. Based on spectral data and magnetic moments, an octahedral geometry may be proposed for Co(II), Ni(II), and Zn(II) complexes while a tetragonal geometry for Cu(II) complex. Molecular structure of the Schiff base ligand and its complexes were studied using programs dedicated to chemical modeling and quantomolecular calculation of chemical properties. All the synthesized complexes were tested forin vitroantibacterial activity against some pathogenic bacterial strains, namelyEscherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus subtilis,andStaphylococcus aureus. The MIC values shown by the complexes against these bacterial strains revealed that the metal complexes possess superior antibacterial activity than the Schiff base.

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