Alterations of hippocampal and prefrontal GABAergic interneurons in an animal model of psychosis induced by NMDA receptor antagonism

2007 ◽  
Vol 97 (1-3) ◽  
pp. 254-263 ◽  
Author(s):  
Isabella Braun ◽  
Just Genius ◽  
Heinz Grunze ◽  
Andreas Bender ◽  
Hans-Jürgen Möller ◽  
...  
Keyword(s):  
Animal Model ◽  
Nmda Receptor ◽  
Gabaergic Interneurons ◽  
Receptor Antagonism

scholarly journals Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1026
Author(s):  
Kristina Holubova ◽  
Marketa Chvojkova ◽  
Barbora Hrcka Krausova ◽  
Vojtech Vyklicky ◽  
Eva Kudova ◽  
...  
Keyword(s):  
Animal Model ◽  
Nmda Receptor ◽  
Neuroactive Steroids ◽  
Stress Exposure ◽  
Mk 801 ◽  
Receptor Modulator ◽  
Receptor Modulation ◽  
Antipsychotic Effect ◽  
Response To Stress ◽  
Systemic Application

Evidence from clinical and preclinical studies implicates dysfunction of N-methyl-D-aspartate receptors (NMDARs) in schizophrenia progression and symptoms. We investigated the antipsychotic effect of two neuroactive steroids in an animal model of schizophrenia induced by systemic application of MK-801. The neuroactive steroids differ in their mechanism of action at NMDARs. MS-249 is positive, while PA-Glu is a negative allosteric NMDAR modulator. We hypothesized that the positive NMDA receptor modulator would attenuate deficits caused by MK-801 co-application more effectively than PA-Glu. The rats were tested in a battery of tests assessing spontaneous locomotion, anxiety and cognition. Contrary to our expectations, PA-Glu exhibited a superior antipsychotic effect to MS-249. The performance of MS-249-treated rats in cognitive tests differed depending on the level of stress the rats were exposed to during test sessions. In particular, with the increasing severity of stress exposure, the performance of animals worsened. Our results demonstrate that enhancement of NMDAR function may result in unspecific behavioral responses. Positive NMDAR modulation can influence other neurobiological processes besides memory formation, such as anxiety and response to stress.

scholarly journals Animal models of cognitive dysfunction and negative symptoms of schizophrenia: Focus on NMDA receptor antagonism

2010 ◽  
Vol 128 (3) ◽  
pp. 419-432 ◽  
Author(s):  
Joanna C. Neill ◽  
Samuel Barnes ◽  
Samantha Cook ◽  
Ben Grayson ◽  
Nagi F. Idris ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Animal Models ◽  
Cognitive Dysfunction ◽  
Negative Symptoms ◽  
Receptor Antagonism

Estrogen and NMDA receptor antagonism: effects upon reference and working memory

1999 ◽  
Vol 381 (2-3) ◽  
pp. 93-99 ◽  
Author(s):  
Iain A Wilson ◽  
Jukka Puoliväli ◽  
Taneli Heikkinen ◽  
Paavo Riekkinen
Keyword(s):  
Working Memory ◽  
Nmda Receptor ◽  
Receptor Antagonism

NMDA Receptor Antagonism for Neuroprotection in a Canine Model of Hypothermic Circulatory Arrest

2021 ◽  
Vol 260 ◽  
pp. 177-189
Author(s):  
Katherine Giuliano ◽  
Eric Etchill ◽  
Xun Zhou ◽  
Cecillia Lui ◽  
Alejandro Suarez-Pierre ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Circulatory Arrest ◽  
Canine Model ◽  
Hypothermic Circulatory Arrest ◽  
Receptor Antagonism

Regulation of motor neuron dendrite growth by NMDA receptor activation

Development ◽  
1994 ◽  
Vol 120 (11) ◽  
pp. 3063-3071 ◽  
Author(s):  
R.G. Kalb
Keyword(s):  
Nmda Receptor ◽  
Motor Neuron ◽  
Cell Body ◽  
Motor Neurons ◽  
Receptor Activation ◽  
Dendrite Growth ◽  
Postnatal Life ◽  
Receptor Antagonism ◽  
Neuron Cell Body ◽  
Early Postnatal Life

Spinal motor neurons undergo great changes in morphology, electrophysiology and molecular composition during development. Some of this maturation occurs postnatally when limbs are employed for locomotion, suggesting that neuronal activity may influence motor neuron development. To identify features of motor neurons that might be regulated by activity we first examined the structural development of the rat motor neuron cell body and dendritic tree labeled with cholera toxin-conjugated horseradish peroxidase. The motor neuron cell body and dendrites in the radial and rostrocaudal axes grew progressively over the first month of life. In contrast, the growth of the dendritic arbor/cell and number of dendritic branches was biphasic with overabundant growth followed by regression until the adult pattern was achieved. We next examined the influence of neurotransmission on the development of these motor neuron features. We found that antagonism of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor inhibited cell body growth and dendritic branching in early postnatal life but had no effect on the maximal extent of dendrite growth in the radial and rostrocaudal axes. The effects of NMDA receptor antagonism on motor neurons and their dendrites was temporally restricted; all of our anatomic measures of dendrite structure were resistant to NMDA receptor antagonism in adults. These results suggest that the establishment of mature motor neuron dendritic architecture results in part from dendrite growth in response to afferent input during a sensitive period in early postnatal life.

scholarly journals Dual Allosteric Effect in Glycine/NMDA Receptor Antagonism: A Comparative QSAR Approach

2010 ◽  
Vol 3 (10) ◽  
pp. 3167-3185 ◽  
Author(s):  
Manish Sharma ◽  
Vipin B. Gupta
Keyword(s):  
Nmda Receptor ◽  
Allosteric Effect ◽  
Receptor Antagonism
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