Reduced fronto-temporal connectivity is associated with frontal gray matter density reduction and neuropsychological deficit in schizophrenia

2009 ◽  
Vol 108 (1-3) ◽  
pp. 57-68 ◽  
Author(s):  
Ilaria Spoletini ◽  
Andrea Cherubini ◽  
Margherita Di Paola ◽  
Giulia Banfi ◽  
Nicolas Rüsch ◽  
...  
2014 ◽  
Vol 4 ◽  
pp. 232-239 ◽  
Author(s):  
Katharina Stegmayer ◽  
Helge Horn ◽  
Andrea Federspiel ◽  
Nadja Razavi ◽  
Tobias Bracht ◽  
...  

2018 ◽  
Vol 172 (2) ◽  
pp. 363-370 ◽  
Author(s):  
Bihong T. Chen ◽  
Taihao Jin ◽  
Sunita K. Patel ◽  
Ningrong Ye ◽  
Can-Lan Sun ◽  
...  

2010 ◽  
Vol 206 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Boris Suchan ◽  
Martin Busch ◽  
Dietmar Schulte ◽  
Dietrich Grönermeyer ◽  
Stephan Herpertz ◽  
...  

2012 ◽  
Vol 517 (1) ◽  
pp. 21-24 ◽  
Author(s):  
Qinling Wei ◽  
Feici Diao ◽  
Zhuang Kang ◽  
Zhaoyu Gan ◽  
Zili Han ◽  
...  

Neuroreport ◽  
2008 ◽  
Vol 19 (6) ◽  
pp. 631-634 ◽  
Author(s):  
Ya-Ting Lv ◽  
Hong Yang ◽  
De-Yi Wang ◽  
Shu-Yu Li ◽  
Ying Han ◽  
...  

2020 ◽  
Author(s):  
Christoph Fraenz ◽  
Dorothea Metzen ◽  
Christian J. Merz ◽  
Helene Selpien ◽  
Nikolai Axmacher ◽  
...  

AbstractResearch has shown that fear acquisition, in reaction to potentially harmful stimuli or situations, is characterized by pronounced interindividual differences. It is likely that such differences are evoked by variability in the macro- and microstructural properties of brain regions involved in the processing of threat or safety signals from the environment. Indeed, previous studies have shown that the strength of conditioned fear reactions is associated with the cortical thickness or volume of various brain regions. However, respective studies were exclusively targeted at single brain regions instead of whole brain networks. Here, we tested 60 young and healthy individuals in a differential fear conditioning paradigm while they underwent fMRI scanning. In addition, we acquired T1-weighted and multi-shell diffusion-weighted images prior to testing. We used task-based fMRI data to define global brain networks which exhibited increased BOLD responses towards CS+ or CS- presentations, respectively. From these networks, we obtained mean values of gray matter density, neurite density, and neurite orientation dispersion. We found that mean gray matter density averaged across the CS+ network was significantly correlated with the strength of conditioned fear reactions quantified via skin conductance response. Measures of neurite architecture were not associated with conditioned fear reaction in any of the two networks. Our results extend previous findings on the relationship between brain morphometry and fear learning. Most importantly, our study is the first to introduce neurite imaging to fear learning research and discusses how its implementation can be improved in future research.


Sign in / Sign up

Export Citation Format

Share Document