Impact of previous tobacco use with or without cannabis on first psychotic experiences in patients with first-episode psychosis

Background. Previous psychosocial stress research, contemporary cognitive models, and new cognitive behavioural treatments for psychosis converge in suggesting that stressful events influence the content of psychotic experiences. In this paper we test whether the attributes of stressful events preceding the initial onset of psychosis are associated with core themes of the illness.Method. Forty-one people who had experienced a first episode of psychosis were assessed on the attributes of stressful events occurring in the year before onset, the themes (persecutory, depressive, and grandiose) associated with their delusions and the content of their auditory hallucinations.Results. Principal component analysis yielded four components accounting for 72% of the variance. As hypothesized, intrusive events were associated with the development of delusions with persecutory themes. Grandiose delusions were negatively associated with loss events. Depressive delusions appear to be associated with danger events rather than loss events.Conclusion. There are links between stressful event attributes and core psychotic themes at first-episode psychosis. This has implications for theoretical models of, and early psychological intervention for, psychosis.

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Patterns and predictors of substance use disorders and daily tobacco use in first-episode psychosis*

Australian & New Zealand Journal of Psychiatry ◽

10.1111/j.1440-1614.2005.01699.x ◽

2005 ◽

Vol 39 (10) ◽

pp. 892-898 ◽

Cited By ~ 2

Author(s):

Darryl Wade ◽

Susy Harrigan ◽

Jane Edwards ◽

Philip M. Burgess ◽

Greg Whelan ◽

...

Keyword(s):

Substance Use ◽

Substance Use Disorders ◽

Tobacco Use ◽

First Episode Psychosis ◽

First Episode ◽

Episode Psychosis

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Childhood abuse in the etiological continuum underlying psychosis from first-episode psychosis to psychotic experiences

European Psychiatry ◽

10.1016/j.eurpsy.2014.08.005 ◽

2015 ◽

Vol 30 (1) ◽

pp. 38-42 ◽

Cited By ~ 4

Author(s):

S. Alemany ◽

R. Ayesa-Arriola ◽

B. Arias ◽

M. Fatjó-Vilas ◽

M.I. Ibáñez ◽

...

Keyword(s):

Childhood Abuse ◽

Regression Models ◽

First Episode Psychosis ◽

Self Report ◽

First Episode ◽

Psychotic Experiences ◽

Logistic Regression Models ◽

Episode Psychosis ◽

Subclinical Psychosis ◽

The Continuum

AbstractGoal:The present study aimed to examine the prevalence of child abuse across the continuum of psychosis.Patients and methods:The sample consisted of 198 individuals divided in three groups: (1) 48 FEP patients, (2) 77 individuals scoring high in Community Assessment of Psychic Experiences (CAPE), classified as “High CAPE” group and (3) 73 individuals scoring low, classified as “Low CAPE” group. Childhood abuse was assessed using self-report instruments. Chi2 tests and logistic regression models controlling by sex, age and cannabis were used to perform three comparisons: (i) FEP vs. Low CAPE; (ii) FEP vs. High CAPE and (iii) High CAPE vs. Low CAPE.Results:The frequency of individuals exposed to childhood abuse for FEP, High CAPE and Low CAPE groups were 52.1%, 41.6% and 11%, respectively. FEP and High CAPE group presented significantly higher rates of childhood abuse compared to Low CAPE group, however, no significant differences were found between FEP and High CAPE groups regarding the frequency of childhood abuse.Conclusion:There is an increasing frequency of childhood abuse from low subclinical psychosis to FEP patients. However, childhood abuse is equally common in FEP and at risk individuals.

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Daily use of high-potency cannabis is associated with more positive symptoms in first-episode psychosis patients: the EU-GEI case–control study

Psychological Medicine ◽

10.1017/s0033291720000082 ◽

2020 ◽

pp. 1-9 ◽

Cited By ~ 3

Author(s):

Diego Quattrone ◽

Laura Ferraro ◽

Giada Tripoli ◽

Caterina La Cascia ◽

Harriet Quigley ◽

...

Keyword(s):

Large Scale ◽

Negative Symptoms ◽

First Episode Psychosis ◽

Cannabis Use ◽

Positive Symptom ◽

Psychotic Symptoms ◽

First Episode ◽

Psychotic Experiences ◽

High Potency ◽

Episode Psychosis

Abstract Background Daily use of high-potency cannabis has been reported to carry a high risk for developing a psychotic disorder. However, the evidence is mixed on whether any pattern of cannabis use is associated with a particular symptomatology in first-episode psychosis (FEP) patients. Method We analysed data from 901 FEP patients and 1235 controls recruited across six countries, as part of the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study. We used item response modelling to estimate two bifactor models, which included general and specific dimensions of psychotic symptoms in patients and psychotic experiences in controls. The associations between these dimensions and cannabis use were evaluated using linear mixed-effects models analyses. Results In patients, there was a linear relationship between the positive symptom dimension and the extent of lifetime exposure to cannabis, with daily users of high-potency cannabis having the highest score (B = 0.35; 95% CI 0.14–0.56). Moreover, negative symptoms were more common among patients who never used cannabis compared with those with any pattern of use (B = −0.22; 95% CI −0.37 to −0.07). In controls, psychotic experiences were associated with current use of cannabis but not with the extent of lifetime use. Neither patients nor controls presented differences in depressive dimension related to cannabis use. Conclusions Our findings provide the first large-scale evidence that FEP patients with a history of daily use of high-potency cannabis present with more positive and less negative symptoms, compared with those who never used cannabis or used low-potency types.

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A retrospective case study of the thematic content of psychotic experiences in a first episode psychosis population

Journal of Mental Health ◽

10.1080/09638237.2020.1755024 ◽

2020 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Amy Jones ◽

John Read ◽

Lisa Wood

Keyword(s):

First Episode Psychosis ◽

First Episode ◽

Psychotic Experiences ◽

Retrospective Case ◽

Thematic Content ◽

Episode Psychosis ◽

Retrospective Case Study

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Cannabis-associated symptom profiles in patients with first episode psychosis and population controls

10.1101/577932 ◽

2019 ◽

Cited By ~ 1

Author(s):

Diego Quattrone ◽

Laura Ferraro ◽

Giada Tripoli ◽

Erika La Cascia ◽

Harriet Quigley ◽

...

Keyword(s):

Negative Symptoms ◽

First Episode Psychosis ◽

Cannabis Use ◽

Psychotic Symptoms ◽

First Episode ◽

Psychotic Experiences ◽

Study Item ◽

Heterogeneous Distribution ◽

Symptom Profiles ◽

Episode Psychosis

AbstractObjectiveThe evidence is mixed on whether cannabis use is associated with a particular symptomatology in first episode psychosis (FEP) patients.The authors set out to investigate a) patterns of association between cannabis use and transdiagnostic symptom dimensions; b) whether the extent of use of cannabis contributes to the variation in clinical and subclinical symptom profiles.MethodThe authors analysed data from 901 patients and 1235 controls recruited across six countries, as part of the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study. Item response modelling was used to estimate two bifactor models, which included general and specific dimensions of psychotic symptoms in patients and psychotic experiences in controls. The associations between these dimensions and cannabis use was evaluated using linear mixed effects models analyses.ResultsIn patients, there was a linear relationship between the positive symptom dimension and the extent of lifetime exposure to cannabis, with daily users of high potency cannabis having the highest score (B=0.35; 95%CI 0.14 to 0.56). Moreover, negative symptoms were more common among patients who never used cannabis compared with those with any pattern of use (B=-0.27; 95%CI −0.42 to −0.12).In controls, psychotic experiences were associated with current use of cannabis but not with the extent of lifetime use.Neither patients nor controls presented differences in the depressive dimension related to cannabis use.ConclusionsThe extent of use of cannabis explains part of the heterogeneous distribution of positive and negative symptoms of FEP patients.

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