scholarly journals Childhood abuse in the etiological continuum underlying psychosis from first-episode psychosis to psychotic experiences

2015 ◽  
Vol 30 (1) ◽  
pp. 38-42 ◽  
Author(s):  
S. Alemany ◽  
R. Ayesa-Arriola ◽  
B. Arias ◽  
M. Fatjó-Vilas ◽  
M.I. Ibáñez ◽  
...  
Keyword(s):  
Childhood Abuse ◽  
Regression Models ◽  
First Episode Psychosis ◽  
Self Report ◽  
First Episode ◽  
Psychotic Experiences ◽  
Logistic Regression Models ◽  
Episode Psychosis ◽  
Subclinical Psychosis ◽  
The Continuum

AbstractGoal:The present study aimed to examine the prevalence of child abuse across the continuum of psychosis.Patients and methods:The sample consisted of 198 individuals divided in three groups: (1) 48 FEP patients, (2) 77 individuals scoring high in Community Assessment of Psychic Experiences (CAPE), classified as “High CAPE” group and (3) 73 individuals scoring low, classified as “Low CAPE” group. Childhood abuse was assessed using self-report instruments. Chi2 tests and logistic regression models controlling by sex, age and cannabis were used to perform three comparisons: (i) FEP vs. Low CAPE; (ii) FEP vs. High CAPE and (iii) High CAPE vs. Low CAPE.Results:The frequency of individuals exposed to childhood abuse for FEP, High CAPE and Low CAPE groups were 52.1%, 41.6% and 11%, respectively. FEP and High CAPE group presented significantly higher rates of childhood abuse compared to Low CAPE group, however, no significant differences were found between FEP and High CAPE groups regarding the frequency of childhood abuse.Conclusion:There is an increasing frequency of childhood abuse from low subclinical psychosis to FEP patients. However, childhood abuse is equally common in FEP and at risk individuals.

Poster #S1 FURTHER EVIDENCE OF THE EFFECTS OF CHILDHOOD ABUSE IN FIRST-EPISODE PSYCHOSIS AND SUBCLINICAL PSYCHOSIS

2014 ◽  
Vol 153 ◽  
pp. S88
Author(s):  
Silvia Alemany ◽  
Rosa Ayesa-Arriola ◽  
Bárbara Arias ◽  
Mar Fatjó-Vilas ◽  
Manuel I. Ibáñez ◽  
...  
Keyword(s):  
Childhood Abuse ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Subclinical Psychosis

scholarly journals Carer subjective burden after first-episode psychosis: Types and predictors. A multilevel statistical approach

2020 ◽  
pp. 002076402093004
Author(s):  
Shereen Charles ◽  
James B Kirkbride ◽  
Juliana Onwumere ◽  
Natasha Lyons ◽  
Lai Chu Man ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
First Episode Psychosis ◽  
Self Report ◽  
First Episode ◽  
Negative Consequences ◽  
Cross Sectional Survey ◽  
Carer Burden ◽  
Regression Modelling ◽  
Episode Psychosis ◽  
Early Intervention In Psychosis

Background: Carer burden at first-episode psychosis is common and adds to the multiple other psychiatric and psychological problems that beset new carers; yet, knowledge of the factors that predict carer burden is limited. Aim: This study sought to investigate the types and predictors of carer burden at first-episode psychosis in the largest, most ethnically diverse and comprehensively characterised sample to date. Method: This study involved a cross-sectional survey of carers of people with first-episode psychosis presenting to Harrow and Hillingdon Early Intervention in Psychosis service between 2011 and 2017. Carers completed self-report measures assessing their illness beliefs, coping styles and caregiving experiences (i.e. burden). Thirty carer and patient sociodemographic and clinical factors were also collected. Mixed effects linear regression modelling was conducted to account for clustering of carers by patient, with carer burden (and its 8 subtypes) investigated as dependent variables. Results: The sample included data on 254 carers (aged 18–74 years) and 198 patients (aged 14–36 years). Regression modelling identified 35 significant predictors of carer burden and its subtypes at first-episode psychosis. Higher total burden was independently predicted by perceiving greater negative consequences of the illness for the patient (B = .014, p < .001, 95% CI: [.010–.018]) and the carer (B = .008, p = .002, 95% CI: [.003–.013]), and engaging in avoidant-focussed coping (B = .010, p = .006, 95% CI: [.003–.016]). Lower burden was independently predicted by patients being in a relationship (B = −.075, p = .047, 95% CI: [−.149 to −.001]). Predictors of the eight burden subtypes (difficult behaviours, negative symptoms, stigma, problems with services, effects on family, dependency, loss and need to backup) are also included in the article. Conclusion: Findings can be used to inform the identification of carers ‘at-risk’ of experiencing burden and highlight potential targets for theraputic intervention to lower carer buden.

Brain derived neurotropic factor (BDNF) is associated with childhood abuse but not cognitive domains in first episode psychosis

2014 ◽  
Vol 159 (1) ◽  
pp. 56-61 ◽  
Author(s):  
Christos Theleritis ◽  
Helen L. Fisher ◽  
Ingo Shäfer ◽  
Laura Winters ◽  
Daniel Stahl ◽  
...  
Keyword(s):  
Childhood Abuse ◽  
First Episode Psychosis ◽  
First Episode ◽  
Cognitive Domains ◽  
Episode Psychosis ◽  
Neurotropic Factor

P.502 Impact of previous tobacco use with or without cannabis on first psychotic experiences in patients with first-episode psychosis

2020 ◽  
Vol 40 ◽  
pp. S281-S282
Author(s):  
L. González-Blanco ◽  
M.P. García-Portilla ◽  
M. Gutiérrez ◽  
G. Mezquida ◽  
M.J. Cuesta ◽  
...  
Keyword(s):  
Tobacco Use ◽  
First Episode Psychosis ◽  
First Episode ◽  
Psychotic Experiences ◽  
Episode Psychosis

scholarly journals Impact of previous tobacco use with or without cannabis on first psychotic experiences in patients with first-episode psychosis

2021 ◽  
Vol 236 ◽  
pp. 19-28
Author(s):  
Leticia González-Blanco ◽  
María Paz García-Portilla ◽  
Miguel Gutiérrez ◽  
Gisela Mezquida ◽  
Manuel J. Cuesta ◽  
...  
Keyword(s):  
Tobacco Use ◽  
First Episode Psychosis ◽  
First Episode ◽  
Psychotic Experiences ◽  
Episode Psychosis

Failure to find association between childhood abuse and cognition in first-episode psychosis patients

2014 ◽  
Vol 29 (1) ◽  
pp. 32-35 ◽  
Author(s):  
L. Sideli ◽  
H.L. Fisher ◽  
M. Russo ◽  
R.M. Murray ◽  
S.A. Stilo ◽  
...  
Keyword(s):  
Executive Function ◽  
Childhood Abuse ◽  
Cognitive Functions ◽  
First Episode Psychosis ◽  
First Episode ◽  
Control Group ◽  
Episode Psychosis ◽  
Function Domain ◽  
The Relationship

AbstractThis study investigated the relationship between severe childhood abuse and cognitive functions in first-episode psychosis patients and geographically-matched controls. Reports of any abuse were associated with lower scores in the executive function domain in the control group. However, in contrast with our hypothesis, no relationships were found amongst cases.

scholarly journals Event attributes and the content of psychotic experiences in first-episode psychosis

2005 ◽  
Vol 36 (2) ◽  
pp. 221-230 ◽  
Author(s):  
DAVID RAUNE ◽  
PAUL BEBBINGTON ◽  
GRAHAM DUNN ◽  
ELIZABETH KUIPERS
Keyword(s):  
Psychological Intervention ◽  
Principal Component ◽  
Theoretical Models ◽  
First Episode Psychosis ◽  
Stressful Events ◽  
First Episode ◽  
Stressful Event ◽  
Psychotic Experiences ◽  
Episode Psychosis ◽  
Initial Onset

Background. Previous psychosocial stress research, contemporary cognitive models, and new cognitive behavioural treatments for psychosis converge in suggesting that stressful events influence the content of psychotic experiences. In this paper we test whether the attributes of stressful events preceding the initial onset of psychosis are associated with core themes of the illness.Method. Forty-one people who had experienced a first episode of psychosis were assessed on the attributes of stressful events occurring in the year before onset, the themes (persecutory, depressive, and grandiose) associated with their delusions and the content of their auditory hallucinations.Results. Principal component analysis yielded four components accounting for 72% of the variance. As hypothesized, intrusive events were associated with the development of delusions with persecutory themes. Grandiose delusions were negatively associated with loss events. Depressive delusions appear to be associated with danger events rather than loss events.Conclusion. There are links between stressful event attributes and core psychotic themes at first-episode psychosis. This has implications for theoretical models of, and early psychological intervention for, psychosis.

Auditory verbal hallucinations in first episode psychosis – an fMRI symptom capture study

2017 ◽  
Vol 41 (S1) ◽  
pp. S194-S194
Author(s):  
T. Dunne ◽  
P. Mallikarjun ◽  
M. Broome ◽  
B. Farmah ◽  
K. Heinze ◽  
...  
Keyword(s):  
Cluster Size ◽  
Chronic Schizophrenia ◽  
First Episode Psychosis ◽  
Self Report ◽  
Network Activity ◽  
First Episode ◽  
Salience Network ◽  
Significant Activity ◽  
Episode Psychosis ◽  
The Right

IntroductionNeurobiological models of auditory verbal hallucination (AVH) have been advanced by symptom capture functional magnetic resonance imaging (fMRI), where participants self-report hallucinations during scanning. To date, regions implicated are those involved with language, memory and emotion. However, previous studies focus on chronic schizophrenia, thus are limited by factors, such as medication use and illness duration. Studies also lack detailed phenomenological descriptions of AVHs. This study investigated the neural correlates of AVHs in patients with first episode psychosis (FEP) using symptom capture fMRI with a rich description of AVHs. We hypothesised that intrusive AVHs would be associated with dysfunctional salience network activity.MethodsSixteen FEP patients with frequent AVH completed four psychometrically validated tools to provide an objective measure of the nature of their AVHs. They then underwent fMRI symptom capture, utilising general linear models analysis to compare activity during AVH to the resting brain.ResultsSymptom capture of AVH was achieved in nine patients who reported intrusive, malevolent and uncontrollable AVHs. Significant activity in the right insula and superior temporal gyrus (cluster size 141 mm3), and the left parahippocampal and lingual gyri (cluster size 121 mm3), P < 0.05 FDR corrected, were recorded during the experience of AVHs.ConclusionsThese results suggest salience network dysfunction (in the right insula) together with memory and language processing area activation in intrusive, malevolent AVHs in FEP. This finding concurs with others from chronic schizophrenia, suggesting these processes are intrinsic to psychosis itself and not related to length of illness or prolonged exposure to antipsychotic medication.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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