Anti epileptic drug trials for patients with drug resistant idiopathic generalised epilepsy: A meta-analysis

: Nowadays, due to the incidence of specific strains of Mycobacterium tuberculosis and also increase the rate of drug resistant-TB mortality rate has elevated by this disease. Identification of common strains in the region as well as sources of transmission are essential to control the disease that this has been possible by using molecular epidemiology. In this survey, studies which have been carried out based on spoligotyping method in Muslim Middle East countries were considered to determine their role in control of TB. All studies conducted from 2005 to June 2016 were considered systematically in three electronic data bases and finally, 23 studies were selected. The average rate of clustering was 84% and the rate of recent transmission was variable from 21.7% to 92.4%. Incidence of Beijing strains was been rising in the considered countries. In Iran and Saudi Arabia which are immigration and labour-hosting countries, respectively, rapid transmittable strains and drug resistant Beijings were higher than other considered countries. Considering the incidence of highly virulent strains, due to the increase of immigration and people infected with HIV, tuberculosis, especially drug resistant form, the lack of close monitoring in the future will be induce trouble.

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Direct susceptibility testing for multi drug resistant tuberculosis: A meta-analysis

BMC Infectious Diseases ◽

10.1186/1471-2334-9-67 ◽

2009 ◽

Vol 9 (1) ◽

Cited By ~ 96

Author(s):

Freddie Bwanga ◽

Sven Hoffner ◽

Melles Haile ◽

Moses L Joloba

Keyword(s):

Susceptibility Testing ◽

Meta Analysis ◽

Drug Resistant ◽

Drug Resistant Tuberculosis ◽

Resistant Tuberculosis ◽

Multi Drug Resistant Tuberculosis

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Comparative efficacy between ketamine, memantine, riluzole and d-cycloserine in patients diagnosed with drug resistant depression: a meta-analysis

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20192174 ◽

2019 ◽

Vol 8 (6) ◽

pp. 1132

Author(s):

Nishita H. Darji ◽

Devang A. Rana ◽

Supriya D. Malhotra

Keyword(s):

Rating Scale ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Fixed Effect ◽

P Value ◽

Drug Resistant ◽

Effect Model ◽

Resistant Depression ◽

Glutamate Modulators

Background: Glutamate modulators are having immense potential and are newer entities for treating drug resistant depression. The objectives were to generate statistical evidence on basis of existing data of ketamine, memantine, riluzole and d-cycloserine in resistant depression.Methods: A total of 14 RCTs following PRISMA guidelines and matching inclusion and exclusion criteria were collected of ketamine (5), memantine (3), riluzole (2) and d-cycloserine (4) vs placebo in drug resistant depression. Only RCTs with primary diagnosis of drug resistant depression (Previously on two standard antidepressant therapy) were included. Studies with treatment response rate, 50% reduction in total score of the depression rating scale-Montgomery-Åsberg Depression Rating Scale or the Hamilton Depression Rating Scale or Beck Depression Inventory was chosen as clinical outcome measure. RevMan 5.3 software was used for the analysis.Results: In ketamine group using random effect model SMD was 2.122 (95% CI 0.659-3.584). P-value was statistically significant (random effect p <0.005 and in fixed effect <0.001). In memantine group, using random effect model -0.963 was SMD and (95% CI -1.958-0.0324). P-value was <0.001, significant in fixed effect. In riluzole group, SMD was -0.564 with (95% CI -3.927-2.799) in random effect. P-value was 0.741. In d-cycloserine group SMD was 0.316 with (95% CI -1.252-1.885) in random effect. P-value was 0.690.Conclusions: Ketamine showed best efficacy followed by memantine. Riluzole and DCS as such have no efficacy although its acts by same glutamate pathway. More molecular based research is required in use of glutamate modulators in resistant depression.

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Prevalence of drug-resistant Pseudomonas aeruginosa in Iranian burned patients: A meta-analysis

Archives of Trauma Research ◽

10.4103/atr.atr_22_17 ◽

2017 ◽

Vol 6 (3) ◽

pp. 1 ◽

Cited By ~ 1

Author(s):

Hossein Dabiri ◽

Samira Tarashi ◽

Mohsen Heidary ◽

MohammadJavad Nasiri

Keyword(s):

Pseudomonas Aeruginosa ◽

Meta Analysis ◽

Drug Resistant

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Pain Outcomes Following Microvascular Decompression for Drug-Resistant Trigeminal Neuralgia: A Systematic Review and Meta-Analysis

Neurosurgery ◽

10.1093/neuros/nyz075 ◽

2019 ◽

Vol 86 (2) ◽

pp. 182-190 ◽

Cited By ~ 8

Author(s):

Katherine Holste ◽

Alvin Y Chan ◽

John D Rolston ◽

Dario J Englot

Keyword(s):

Trigeminal Neuralgia ◽

Microvascular Decompression ◽

Disease Duration ◽

Meta Analysis ◽

Cochrane Library ◽

Superior Cerebellar Artery ◽

Drug Resistant ◽

Pain Outcomes

Abstract BACKGROUND Microvascular decompression (MVD) is a potentially curative surgery for drug-resistant trigeminal neuralgia (TN). Predictors of pain freedom after MVD are not fully understood. OBJECTIVE To describe rates and predictors for pain freedom following MVD. METHODS Using preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, PubMed, Cochrane Library, and Scopus were queried for primary studies examining pain outcomes after MVD for TN published between 1988 and March 2018. Potential biases were assessed for included studies. Pain freedom (ie, Barrow Neurological Institute score of 1) at last follow-up was the primary outcome measure. Variables associated with pain freedom on preliminary analysis underwent formal meta-analysis. Odds ratios (OR) and 95% confidence intervals (CI) were calculated for possible predictors. RESULTS Outcome data were analyzed for 3897 patients from 46 studies (7 prospective, 39 retrospective). Overall, 76.0% of patients achieved pain freedom after MVD with a mean follow-up of 1.7 ± 1.3 (standard deviation) yr. Predictors of pain freedom on meta-analysis using random effects models included (1) disease duration ≤5 yr (OR = 2.06, 95% CI = 1.08-3.95); (2) arterial compression over venous or other (OR = 3.35, 95% CI = 1.91-5.88); (3) superior cerebellar artery involvement (OR = 2.02, 95% CI = 1.02-4.03), and (4) type 1 Burchiel classification (OR = 2.49, 95% CI = 1.32-4.67). CONCLUSION Approximately three-quarters of patients with drug-resistant TN achieve pain freedom after MVD. Shorter disease duration, arterial compression, and type 1 Burchiel classification may predict more favorable outcome. These results may improve patient selection and provider expectations.

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