scholarly journals Comparing the efficacy of sodium valproate and levetiracetam following initial lorazepam in elderly patients with generalized convulsive status epilepticus (GCSE): A prospective randomized controlled pilot study

Seizure ◽  
2019 ◽  
Vol 65 ◽  
pp. 111-117 ◽  
Author(s):  
Devavrat Nene ◽  
Ravindranadh Chowdary Mundlamuri ◽  
Parthasarathy Satishchandra ◽  
Parthipulli Vasuki Prathyusha ◽  
Madhu Nagappa ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Pilot Study ◽  
Elderly Patients ◽  
Sodium Valproate ◽  
Convulsive Status Epilepticus ◽  
Randomized Controlled

scholarly journals The Status of Intravenous Valproate for Status

2007 ◽  
Vol 7 (4) ◽  
pp. 96-98 ◽  
Author(s):  
Lawrence J. Hirsch
Keyword(s):  
Status Epilepticus ◽  
Pilot Study ◽  
Side Effects ◽  
Sodium Valproate ◽  
Convulsive Status Epilepticus ◽  
The Status

Sodium Valproate vs Phenytoin in Status Epilepticus: A Pilot Study. Misra UK, Kalita J, Patel R. Neurology 2006;67(2):340–342. Sixty-eight patients with convulsive status epilepticus (SE) were randomly assigned to two groups to study the efficacy of sodium valproate (VPA) and phenytoin (PHT). Seizures were aborted in 66% in the VPA group and 42% in the PHT group. As a second choice in refractory patients, VPA was effective in 79% and PHT was effective in 25%. The side effects in the two groups did not differ. Sodium valproate may be preferred in convulsive SE because of its higher efficacy.

Preoperative therapeutic programme for elderly patients scheduled for elective abdominal oncological surgery: a randomized controlled pilot study

2010 ◽  
Vol 24 (7) ◽  
pp. 614-622 ◽  
Author(s):  
JJ Dronkers ◽  
H. Lamberts ◽  
IMMD Reutelingsperger ◽  
RH Naber ◽  
CM Dronkers-Landman ◽  
...  
Keyword(s):  
Pilot Study ◽  
Elderly Patients ◽  
Oncological Surgery ◽  
Randomized Controlled ◽  
Therapeutic Programme

scholarly journals Evaluation of the efficacy of sodium valproate in convulsive status epilepticus following to ıschemic stroke

2015 ◽  
Vol 73 (4) ◽  
pp. 293-297 ◽  
Author(s):  
Hasan Hüseyin Özdemir ◽  
Bülent Müngen ◽  
Selçuk İlhan
Keyword(s):  
Ischemic Stroke ◽  
Status Epilepticus ◽  
Side Effects ◽  
Ischaemic Stroke ◽  
Sodium Valproate ◽  
Biochemical Parameters ◽  
Convulsive Status Epilepticus ◽  
Allergic Reactions ◽  
Significant Deterioration ◽  
Before And After

Objective : Convulsive status epilepticus (CSE) is very rarely observed after ischaemic stroke. Sodium valproate (SV) is one of the agents used in the treatment of CSE, but its role still controversial, and its degree of efficacy in treating CSE that develops following stroke is unclear. Method : We evaluated 19 patients who were treated with intravenous (IV) SV (20 mg/kg, 2 mg/kg/h-12h) after diazepam. Patients’ modified Rankin scores (mRS), SE types, and changes in biochemical parameters after treatment were assessed. Results : CSE was successfully treated in 12 (63.15%) patients. Side effects such as hypotension and allergic reactions were observed in two patients. Refractory SE development was observed in 5 (29.4%) patients with high mRS (˃ 3). No significant deterioration in patients’ laboratory evaluations, conducted before and after status, was observed. Conclusion : SV may be safe and effective in the treatment of CSE observed after ischaemic stroke, especially in patients with low mRS.

scholarly journals Sodium valproate suppresses abnormal neurogenesis induced by convulsive status epilepticus

2019 ◽  
Vol 14 (3) ◽  
pp. 480
Author(s):  
Li Jiang ◽  
Peng Wu ◽  
Yue Hu ◽  
Xiu-Juan Li ◽  
Min Cheng
Keyword(s):  
Status Epilepticus ◽  
Sodium Valproate ◽  
Convulsive Status Epilepticus
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