scholarly journals Evaluation of the efficacy of sodium valproate in convulsive status epilepticus following to ıschemic stroke

2015 ◽  
Vol 73 (4) ◽  
pp. 293-297 ◽  
Author(s):  
Hasan Hüseyin Özdemir ◽  
Bülent Müngen ◽  
Selçuk İlhan
Keyword(s):  
Ischemic Stroke ◽  
Status Epilepticus ◽  
Side Effects ◽  
Ischaemic Stroke ◽  
Sodium Valproate ◽  
Biochemical Parameters ◽  
Convulsive Status Epilepticus ◽  
Allergic Reactions ◽  
Significant Deterioration ◽  
Before And After

Objective : Convulsive status epilepticus (CSE) is very rarely observed after ischaemic stroke. Sodium valproate (SV) is one of the agents used in the treatment of CSE, but its role still controversial, and its degree of efficacy in treating CSE that develops following stroke is unclear. Method : We evaluated 19 patients who were treated with intravenous (IV) SV (20 mg/kg, 2 mg/kg/h-12h) after diazepam. Patients’ modified Rankin scores (mRS), SE types, and changes in biochemical parameters after treatment were assessed. Results : CSE was successfully treated in 12 (63.15%) patients. Side effects such as hypotension and allergic reactions were observed in two patients. Refractory SE development was observed in 5 (29.4%) patients with high mRS (˃ 3). No significant deterioration in patients’ laboratory evaluations, conducted before and after status, was observed. Conclusion : SV may be safe and effective in the treatment of CSE observed after ischaemic stroke, especially in patients with low mRS.

scholarly journals The Status of Intravenous Valproate for Status

2007 ◽  
Vol 7 (4) ◽  
pp. 96-98 ◽  
Author(s):  
Lawrence J. Hirsch
Keyword(s):  
Status Epilepticus ◽  
Pilot Study ◽  
Side Effects ◽  
Sodium Valproate ◽  
Convulsive Status Epilepticus ◽  
The Status

Sodium Valproate vs Phenytoin in Status Epilepticus: A Pilot Study. Misra UK, Kalita J, Patel R. Neurology 2006;67(2):340–342. Sixty-eight patients with convulsive status epilepticus (SE) were randomly assigned to two groups to study the efficacy of sodium valproate (VPA) and phenytoin (PHT). Seizures were aborted in 66% in the VPA group and 42% in the PHT group. As a second choice in refractory patients, VPA was effective in 79% and PHT was effective in 25%. The side effects in the two groups did not differ. Sodium valproate may be preferred in convulsive SE because of its higher efficacy.

Non-convulsive status epilepticus after ischemic stroke: a hospital-based stroke cohort study

2014 ◽  
Vol 261 (11) ◽  
pp. 2136-2142 ◽  
Author(s):  
Vincenzo Belcastro ◽  
Simone Vidale ◽  
Gaetano Gorgone ◽  
Laura Rosa Pisani ◽  
Luigi Sironi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Ischemic Stroke ◽  
Status Epilepticus ◽  
Convulsive Status Epilepticus

scholarly journals Sodium valproate suppresses abnormal neurogenesis induced by convulsive status epilepticus

2019 ◽  
Vol 14 (3) ◽  
pp. 480
Author(s):  
Li Jiang ◽  
Peng Wu ◽  
Yue Hu ◽  
Xiu-Juan Li ◽  
Min Cheng
Keyword(s):  
Status Epilepticus ◽  
Sodium Valproate ◽  
Convulsive Status Epilepticus

Convulsive status epilepticus after ischemic stroke and intracerebral hemorrhage: frequency, predictors, and impact on outcome in a large administrative dataset

2007 ◽  
Vol 7 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Brian T. Bateman ◽  
Jan Claassen ◽  
Joshua Z. Willey ◽  
Lawrence J. Hirsch ◽  
Stephan A. Mayer ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Status Epilepticus ◽  
Intracerebral Hemorrhage ◽  
Convulsive Status Epilepticus ◽  
Administrative Dataset

scholarly journals Clinical features and prognostic factors for status epilepticus in the pediatric emergency department: A retrospective study

2021 ◽  
Author(s):  
Sohyun Eun ◽  
Hye Eun Kwon ◽  
Heoung Jin Kim ◽  
Seo Hee Yoon ◽  
Moon Kyu Kim ◽  
...  
Keyword(s):  
Emergency Department ◽  
Status Epilepticus ◽  
Clinical Features ◽  
Pediatric Emergency ◽  
Convulsive Status Epilepticus ◽  
Pediatric Emergency Department ◽  
First Line ◽  
Before And After ◽  
Icu Management ◽  
The Brain

Abstract Background: Uncontrolled seizures cause damage to all organs, especially the brain. Although there are guidelines regarding the management of status epilepticus (SE) involving motor seizures, the timing for administering first-line rescue medications (RMeds) remains unclear. Therefore, we analyzed patients with persistent SE lasting for >30 min and who visited the pediatric emergency department (pED) to determine clinical features and risk factors and provide directions for management on arrival to the pED. Methods: This study was conducted by retrospectively reviewing medical charts of patients aged 0–19 years who were diagnosed with SE accompanying motor seizures and who visited the pED between January 2010 and December 2019. After pED arrival, patients were divided into two groups, namely ≥30 min (n = 12) and <30 min (n = 13), according to the additional seizure time and receipt of the first dose of RMeds before and after 5 min.Results: Seizures lasting for <30 min were mainly observed for the etiology of idiopathic SE in the pED. Among four SE patients who needed intensive care unit (ICU) management, three had delayed administration of RMeds of more than 5 min, which was statistically significant because more hospitalizations in the ICU were observed when RMed administration was delayed. (p = 0.047). In acute symptomatic SE such as encephalitis, more than three doses of RMeds were needed to stop seizures.Conclusions: Patients with convulsive status epilepticus should receive RMeds after arrival at the pED.

scholarly journals Effect of Sodium Valproate on Cognitive Function and Hippocampus of Rats After Convulsive Status Epilepticus

2016 ◽  
Vol 22 ◽  
pp. 5197-5205 ◽  
Author(s):  
Peng Wu ◽  
Siqi Hong ◽  
Min Zhong ◽  
Yi Guo ◽  
Hengsheng Chen ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Cognitive Function ◽  
Sodium Valproate ◽  
Convulsive Status Epilepticus
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