scholarly journals Virological surveillance, molecular phylogeny, and evolutionary dynamics of hepatitis C virus subtypes 1a and 4a isolates in patients from Saudi Arabia

2020 ◽  
Author(s):  
Waleed H. AlMalki ◽  
Imran Shahid ◽  
Ashraf N. Abdalla ◽  
Ayman K. Johargy ◽  
Muhammad Ahmed ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Molecular Phylogeny ◽  
Evolutionary Dynamics ◽  
Virological Surveillance

Reconstruction of the evolutionary dynamics of the hepatitis C virus 1b epidemic in Turkey

2011 ◽  
Vol 11 (5) ◽  
pp. 863-868 ◽  
Author(s):  
Massimo Ciccozzi ◽  
Anna-Rita Ciccaglione ◽  
Alessandra Lo Presti ◽  
Tulay Yalcinkaya ◽  
Zeynep Pinar Taskan ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Evolutionary Dynamics

scholarly journals Variations in DEPDC5 gene and its association with chronic hepatitis C virus infection in Saudi Arabia

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Mashael R Al-Anazi ◽  
Sabine Matou-Nasri ◽  
Ayman A Abdo ◽  
Faisal M Sanai ◽  
Mohammed Q Khan ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Chronic Hepatitis C ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus

scholarly journals Contribution of insertions and deletions to the variability of hepatitis C virus populations

2007 ◽  
Vol 88 (8) ◽  
pp. 2198-2203 ◽  
Author(s):  
Manuela Torres-Puente ◽  
José M. Cuevas ◽  
Nuria Jiménez-Hernández ◽  
María A. Bracho ◽  
Inmaculada García-Robles ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Evolutionary Dynamics ◽  
Antiviral Treatment ◽  
Serum Samples ◽  
Frequency Distributions ◽  
Sequencing Project ◽  
Biologically Relevant ◽  
Insertions And Deletions ◽  
Hypervariable Regions

Little is known about the potential effects of insertions and deletions (indels) on the evolutionary dynamics of hepatitis C virus (HCV). In fact, the consequences of indels on antiviral treatment response are a field of investigation completely unexplored. Here, an extensive sequencing project was undertaken by cloning and sequencing serum samples from 25 patients infected with HCV subtype 1a and 48 patients with subtype 1b. For 23 patients, samples obtained after treatment with alpha interferon plus ribavirin were also available. Two genome fragments containing the hypervariable regions in the envelope 2 glycoprotein and the PKR-BD domain in NS5A were sequenced, yielding almost 16 000 sequences. Our results show that insertions are quite rare, but they are often present in biologically relevant domains of the HCV genome. Moreover, their frequency distributions between different time samples reflect the quasispecies dynamics of HCV populations. Deletions seem to be subject to negative selection.

scholarly journals Molecular characterization and epidemic history of hepatitis C virus using core sequences of isolates from Central Province, Saudi Arabia

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184163 ◽  
Author(s):  
Medhat K. Shier ◽  
James C. Iles ◽  
Mohammad S. El-Wetidy ◽  
Hebatallah H. Ali ◽  
Mohammad M. Al Qattan
Keyword(s):  
Saudi Arabia ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Molecular Characterization ◽  
Central Province ◽  
History Of

38 EVOLUTIONARY DYNAMICS OF HEPATITIS C VIRUS DURING VERY EARLY INFECTIONS: VIROLOGICAL AND IMMUNOLOGICAL INSIGHTS

2011 ◽  
Vol 54 ◽  
pp. S18
Author(s):  
F. Luciani ◽  
R. Bull ◽  
K. Mcelroy ◽  
S. Pham ◽  
B. Cameron ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Evolutionary Dynamics

Epidemiology of hepatitis C virus: a study of male blood donors in Saudi Arabia

Transfusion ◽  
1994 ◽  
Vol 34 (2) ◽  
pp. 135-137 ◽  
Author(s):  
M Abdelaal ◽  
D Rowbottom ◽  
T Zawawi ◽  
T Scott ◽  
C Gilpin
Keyword(s):  
Saudi Arabia ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Donors
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