Could non-HDL-cholesterol be a better marker of atherogenic dyslipidemia in obstructive sleep apnea?

2021 ◽  
Author(s):  
Ozen K. Basoglu ◽  
Mehmet Sezai Tasbakan ◽  
Meral Kayikcioglu
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Hdl Cholesterol ◽  
Atherogenic Dyslipidemia ◽  
Obstructive Sleep

scholarly journals Can Monocyte To HDL Ratio Be A New Marker For Severity Of Obstructive Sleep Apnea Syndrome?

2020 ◽  
Vol 6 (4) ◽  
pp. 1-4
Author(s):  
Yousef AM ◽  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Excessive Daytime Sleepiness ◽  
Sleep Apnea Syndrome ◽  
Hdl Cholesterol ◽  
Apnea Hypopnea Index ◽  
Cholesterol Ratio ◽  
Obstructive Sleep ◽  
Apnea Syndrome

This study aimed to investigate the relation of serum monocyte to serum HDL cholesterol ratio (MHR) with Obstructive Sleep Apnea Syndrome (OSAS). A total of 62 patients with an Apnea Hypopnea Index (AHI > 5) and excessive daytime sleepiness were included in this study as OSAS group. The individuals with (AHI<5/h) were included in the study as controls.

scholarly journals 0613 The Effects of Diabetes on Obstructive Sleep Apnea Severity and Progression: A Propensity Score Analysis

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A234-A235
Author(s):  
Q Li ◽  
B T Keenan ◽  
N M Punjabi ◽  
G Maislin ◽  
S T Kuna
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Propensity Score ◽  
Propensity Score Analysis ◽  
Hdl Cholesterol ◽  
Health Study ◽  
Obstructive Sleep Apnea Severity ◽  
Score Analysis ◽  
Obstructive Sleep ◽  
Independent Association

Abstract Introduction Obstructive sleep apnea (OSA) is associated with increased glucose intolerance and insulin resistance, and commonly coexists with type 2 diabetes mellitus (T2DM). Research suggests an independent association between these two conditions. However, more research into the role of T2DM in the development of OSA, or vice versa, is needed. Methods Leveraging data from 139 participants with T2DM from the Sleep AHEAD cohort and 5,085 participants without T2DM from the Sleep Heart Health Study (SHHS), we conducted two complementary propensity score (PS) subclassification analyses to estimate the effect of T2DM on the oxygen desaturation index (ODI), both at baseline and over 4-5 years of follow-up. PS models included age, sex, race, body mass index, neck circumference, waist circumference, total cholesterol, HDL cholesterol, triglycerides, Epworth Sleepiness Scale, and comorbid hypertension or cardiovascular disease. Models evaluating ODI progression also included baseline ODI. Results The PS subclassification analysis identified 109 participants with T2DM and 480 without T2DM, balanced with respect to baseline covariates, for evaluation of the effect of T2DM on baseline ODI. On average, those with T2DM had a 9 events/hour greater ODI compared to those without (24.3 [20.8, 27.9] vs. 15.3 [13.6, 16.9] events/hour; p&lt;0.0001). Among patients with baseline ODI≥5, a second PS subclassification identified 99 with T2DM and 227 without for evaluating the effect of T2DM on ODI progression. No difference in change in ODI was observed between those with and without T2DM (mean [95% CI] difference -0.25 [-10.7, 10.2] events/hour; p=0.963). Conclusion Using two robust PS subclassification designs to minimize selection bias, we evaluated the effect of T2DM on baseline ODI and ODI progression in adults with OSA after 4-5 years. Those with T2DM had more severe baseline ODI, but there were no meaningful differences in ODI progression. Results further our understanding of the association between these coexisting conditions. Support NIH grant HL070301

scholarly journals Monocyte to HDL cholesterol ratio as a marker of the presence and severity of obstructive sleep apnea in hypertensive patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Min Sun ◽  
Chao Liang ◽  
Hui Lin ◽  
Yuezhi Meng ◽  
Qunzhong Tang ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Area Under The Curve ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Control Group ◽  
Apnea Hypopnea Index ◽  
Hypertensive Patients ◽  
Cholesterol Ratio ◽  
Obstructive Sleep

AbstractThis study aimed to investigate the correlation between monocyte to high-density lipoprotein cholesterol ratio (MHR) and obstructive sleep apnea (OSA) in patients with hypertension. A total of 246 hypertensive patients (67 controls, 65 mild, 51 moderate, and 63 severe OSA) were included. The relationship between MHR and OSA was analyzed. MHR correlated positively with apnea–hypopnea index (AHI), while negatively with mean SpO2 (P < 0.01). MHR was higher in OSA group than the control group (9.2 ± 2.6 vs. 10.8 ± 3.6, P < 0.001). Moreover, MHR in severe OSA group was the highest among all groups (9.2 ± 2.6, 10.2 ± 3.2, 10.4 ± 4.0, and 11.8 ± 3.4 in control, mild, moderate, and severe OSA group, respectively, P < 0.001). Logistic regression analysis demonstrated that MHR was an independent predictor of the presence of OSA (OR = 1.152, P < 0.01) and severe OSA (OR = 1.142, P < 0.01). Area under the curve of MHR was 0.634 (P < 0.05) and 0.660 (P < 0.05) for predicting OSA and severe OSA respectively in the ROC analysis. In conclusion, MHR increased with the severity of OSA. As a practical and cost-effective test, MHR was expected to be an available marker in evaluating OSA risk and severity in hypertensive patients.

scholarly journals Can Monocyte to HDL Ratio be a new Marker for Severity of Obstructive Sleep Apnea Syndrome?

2020 ◽  
pp. 1-4
Author(s):  
Aida Mahmoud Yousef ◽  
◽  
Jehan J El-Jawhari ◽  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Hdl Cholesterol ◽  
Control Group ◽  
Monocyte Count ◽  
Cholesterol Ratio ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Background: This study aimed to investigate the relation of serum monocyte to serum HDL cholesterol ratio (MHR) with obstructive sleep apnea syndrome (OSAS). A total of 62 patients with an apnea hypopnea index (AHI > 5) and excessive daytime sleepiness were included in this study as OSAS group. The individuals with (AHI) < 5/h were included in the study as controls. OSAS patients were compared with the control group for high density lipoprotein (HDL) levels, serum monocyte count, and monocyte to HDL ratio (MHR). Mild, moderate and severe OSAS subgroups were compared for the same parameters. Results: MHR was 11.93 ± 6.52 in the control group while it was 14.87 ± 6.98 in OSAS group, with a statistically significant difference in between them (p= 0.016). The MHR were positively correlated with AHI and the minimum oxygen saturation (p = 0.003 and p = 0.012, respectively). Conclusion: serum monocyte to serum HDL cholesterol ratio increased as OSAS severity increased. MHR is an easy and available biomarker. It can be used as a new marker for severity of OSAS

scholarly journals Monocyte to HDL cholesterol ratio as a marker of the presence and severity of obstructive sleep apnea in hypertensive patients

2021 ◽  
Author(s):  
Min Sun ◽  
Chao Liang ◽  
Hui Lin ◽  
Yuezhi Meng ◽  
Qunzhong Tang ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Area Under The Curve ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Control Group ◽  
Apnea Hypopnea Index ◽  
Hypertensive Patients ◽  
Cholesterol Ratio ◽  
Obstructive Sleep

Abstract This study aimed to investigate the correlation between monocyte to high-density lipoprotein cholesterol ratio (MHR) and obstructive sleep apnea (OSA) in patients with hypertension. A total of 246 hypertensive patients (67 controls, 65 mild, 51 moderate, and 63 severe OSA) were included. The relationship between MHR and OSA was analyzed. MHR correlated positively with apnea-hypopnea index (AHI), while negatively with mean SpO2 (P < 0.01). MHR was higher in OSA group than the control group (9.2 ± 2.6 vs. 10.8 ± 3.6, P < 0.001). Moreover, MHR in severe OSA group was the highest among all groups (9.2 ± 2.6, 10.2 ± 3.2, 10.4 ± 4.0, and 11.8 ± 3.4 in control, mild, moderate, and severe OSA group, respectively, P < 0.001). Logistic regression analysis demonstrated that MHR was an independent predictor of the presence of OSA (OR = 1.152, P < 0.01) and severe OSA (OR = 1.144, P < 0.01). Area under the curve of MHR was 0.634 (P < 0.05) and 0.660 (P < 0.05) for predicting OSA and severe OSA respectively in the ROC analysis. In conclusion, MHR increased with the severity of OSA. As a practical and cost-effective test, MHR was expected to be an available marker in evaluating OSA risk and severity in hypertensive patients.

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