Association of Metabolic Syndrome Prior to Gastric Bypass Surgery and Long-Term Weight Loss Outcomes: the Utah Obesity Study

Gastric bypass surgery results in long-term weight loss due to re-routing of the gastro-intestinal anatomy and dietary intake alterations. Studies have examined protein change during rapid weight loss (up to 1 year post-surgery), but whether protein changes are maintained long-term after weight stabilization is unknown. To identify proteins and pathways involved with the long-term beneficial effects of weight loss, abundances of 1297 blood-circulating proteins were measured at baseline, 2 and 12 years after Roux-en-Y gastric bypass surgery. Protein changes were compared between 234 surgery and 144 non-surgery subjects with severe obesity, with discovery and replication subgroups. Seventy-one protein changes were associated with 12-year BMI changes and 58 (7 unique) with surgical status. Protein changes, including ApoM, were most strongly associated with long-term changes in lipids (HDL-C and triglycerides). Inflammation, adipogenesis, cellular signaling, and complement pathways were implicated. Short-term improvements in protein levels were maintained long-term, even after some weight regain.

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Patients Lacking Sustainable Long-Term Weight Loss after Gastric Bypass Surgery Show Signs of Decreased Inhibitory Control of Prepotent Responses

PLoS ONE ◽

10.1371/journal.pone.0119896 ◽

2015 ◽

Vol 10 (3) ◽

pp. e0119896 ◽

Cited By ~ 5

Author(s):

Pleunie S. Hogenkamp ◽

Magnus Sundbom ◽

Victor C. Nilsson ◽

Christian Benedict ◽

Helgi B. Schiöth

Keyword(s):

Weight Loss ◽

Gastric Bypass ◽

Inhibitory Control ◽

Bypass Surgery ◽

Gastric Bypass Surgery ◽

Prepotent Responses

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Psychological characteristics and associations with weight outcomes two years after gastric bypass surgery: Postoperative eating disorder symptoms are associated with weight loss outcomes

Eating Behaviors ◽

10.1016/j.eatbeh.2012.06.001 ◽

2012 ◽

Vol 13 (4) ◽

pp. 394-397 ◽

Cited By ~ 36

Author(s):

Nina N. Beck ◽

Mimi Mehlsen ◽

René K. Støving

Keyword(s):

Weight Loss ◽

Gastric Bypass ◽

Eating Disorder ◽

Bypass Surgery ◽

Gastric Bypass Surgery ◽

Psychological Characteristics ◽

Eating Disorder Symptoms ◽

Weight Outcomes ◽

Weight Loss Outcomes

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Long-Term Weight Loss after Gastric Bypass Surgery. What Are the Predictors for Success?

Journal of Surgical Research ◽

10.1016/j.jss.2009.11.588 ◽

2010 ◽

Vol 158 (2) ◽

pp. 384

Author(s):

I. Leitman ◽

D. Edrich ◽

M. Bogart

Keyword(s):

Weight Loss ◽

Gastric Bypass ◽

Bypass Surgery ◽

Gastric Bypass Surgery

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Influence of the gastric stump’s volume on the long-term results of laparoscopic Roux-en-Y gastric bypass surgery

Grekov s Bulletin of Surgery ◽

10.24884/0042-4625-2021-180-1-81-88 ◽

2021 ◽

Vol 180 (1) ◽

pp. 81-88

Author(s):

A. G. Khitaryan ◽

D. A. Melnikov ◽

A. A. Orekhov ◽

A. V. Mezhunts ◽

S. A. Adizov ◽

...

Keyword(s):

Weight Loss ◽

Gastric Bypass ◽

Weight Gain ◽

Bypass Surgery ◽

Gastric Bypass Surgery ◽

Long Term Results ◽

Gastric Stump ◽

Insufficient Weight Loss

The objective was to retrospectively analyze the dependence of long-term results of laparoscopic Roux-en-Y gastric bypass surgery according to the size of the formed gastric stumpMethods and materials. We retrospectively analyzed the long-term results of 207 morbidly obese patients who underwent laparoscopic Roux-en-Y gastric bypass surgery by two different techniques. The median follow-up was 36 months. Two groups of patients were identified according to the method of formation of the gastric stump: using 2 (1st group) or 3 (2nd group) stapler cassettes and performing of computed tomography volumetry to determine thevolume of the created gastric stump.Results. Statistically significant differences in the volume of the formed gastric stump, depending on the method of operation, were as follows: 23.8 ml (8.9–37.3 ml) in the 1st group and 47.7 ml (31.9–72.8 ml) in the 2nd group (p<0.0001). Significant differences were observed in the following indicators: relapse of weight gain or insufficient weight loss (loss of < 70 % overweight) at median follow-up of 36 months were observed in 2 (2.3 %) and 12 (9.9 %) cases in the 1st and 2nd groups, respectively (p<0.05).Conclusion. We revealed that the formation of the gastric stump of a very small volume by 2 stapler cassettes compared to using 3 stapler cassettes contributes to improving the results in the long-term postoperative period and minimizing the frequency of relapse of weight gain and insufficient weight loss. The restrictive component of the surgery with equal malabsorptive is fundamental for the clinical parameters of its effectiveness, that leads to increasing the frequency of relapses of weight gain and insufficient weight loss in the 2nd group in comparison with the 1st and group of patients (p<0.05). Based on computed tomography volumetry, the volume of a small-sized stomach stump can be reliably measured and, accordingly, weight loss is predicted in the long term after the surgery, as well as the absence of relapses of weight gain or insufficient weight loss.

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