Twelve-year changes in protein profiles in patients with and without gastric bypass surgery

Gastric bypass surgery results in long-term weight loss due to re-routing of the gastro-intestinal anatomy and dietary intake alterations. Studies have examined protein change during rapid weight loss (up to 1 year post-surgery), but whether protein changes are maintained long-term after weight stabilization is unknown. To identify proteins and pathways involved with the long-term beneficial effects of weight loss, abundances of 1297 blood-circulating proteins were measured at baseline, 2 and 12 years after Roux-en-Y gastric bypass surgery. Protein changes were compared between 234 surgery and 144 non-surgery subjects with severe obesity, with discovery and replication subgroups. Seventy-one protein changes were associated with 12-year BMI changes and 58 (7 unique) with surgical status. Protein changes, including ApoM, were most strongly associated with long-term changes in lipids (HDL-C and triglycerides). Inflammation, adipogenesis, cellular signaling, and complement pathways were implicated. Short-term improvements in protein levels were maintained long-term, even after some weight regain.

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Determinants of Adequate Response of Patient Undergoing Roux-en-y Gastric Bypass Surgery

10.21203/rs.3.rs-59391/v1 ◽

2020 ◽

Author(s):

Thales Philipe Rodrigues Silva ◽

Flávia Moraes Silva ◽

Larissa Loures Mendes ◽

Alexandra Dias Moreira D'assunção ◽

Lauro Pinheiro Ferreira de Araujo ◽

...

Keyword(s):

Weight Loss ◽

Gastric Bypass ◽

Logistic Regression ◽

Bypass Surgery ◽

Gastric Bypass Surgery ◽

Inadequate Response ◽

Post Surgery ◽

Adequate Response ◽

Follow Up Care

Abstract INTRODUCTION: Roux-en-Y gastric bypass surgery (RYGB) is known to induce, on average,60 to 75% excess body weight loss between 18 and 24 months post-surgery. However, several studies have shown weight regain after two years post-surgery, thus patients must have adequate follow-up in order to guarantee and/or maintain response to RYGB. AIM: To evaluate the determinants of adequate response in patients who underwent RYGB. METHODS: A longitudinal study with 193 adults who underwent RYGB between 2012 and 2014. Adequate response to RYGB was determined by Excess Weight Loss (%EWL). Logistic regression models were constructed to verify the degree of association between adequate response of patient after RYGB and determinants of variable risk based on estimate Odds Ratios (OR). RESULTS: RYGB improves Systemic arterial hypertension (SAH), Diabetes Mellitus (DM) and body mass index (BMI). From the multivariate logistic regression model, being female and not having SAH and DM reduce the chance of inadequate RYGB response. Regarding preoperative BMI, an increase in one unit of kg/m2 was associated with increased odds of inadequate response after RYGB. And patients who did not receive follow-up care with a psychologist or psychiatrist in the postoperative period presented higher odds of inadequate response to RYGB. CONCLUSION: The findings of this study contribute to the effective planning of interventions by multi-professional teams involved in RYGB, aimed at offering a better follow-up care focused mainly on post-surgery changes and adequate RYGB response.

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Association of Metabolic Syndrome Prior to Gastric Bypass Surgery and Long-Term Weight Loss Outcomes: the Utah Obesity Study

Surgery for Obesity and Related Diseases ◽

10.1016/j.soard.2017.09.038 ◽

2017 ◽

Vol 13 (10) ◽

pp. S16-S17

Author(s):

Rodrick McKinlay ◽

Jaewhan Kim ◽

Lance Davidson ◽

Steven Simper ◽

Ted Adams ◽

...

Keyword(s):

Metabolic Syndrome ◽

Weight Loss ◽

Gastric Bypass ◽

Bypass Surgery ◽

Gastric Bypass Surgery ◽

Weight Loss Outcomes

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Long-Term Beneficial Effects of Laparoscopic Roux-en-Y Gastric Bypass Surgery on Functionality and Body Posture in Obese Patients

Shiraz E-Medical Journal ◽

10.5812/semj.68515 ◽

2018 ◽

Vol In Press (In Press) ◽

Author(s):

Farinaz Fahimipour ◽

Parisa Nejati ◽

Ali Mazaherinezhad

Keyword(s):

Gastric Bypass ◽

Bypass Surgery ◽

Gastric Bypass Surgery ◽

Body Posture ◽

Obese Patients ◽

Beneficial Effects

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Long-term changes in energy expenditure and body composition after massive weight loss induced by gastric bypass surgery

American Journal of Clinical Nutrition ◽

10.1093/ajcn/78.1.22 ◽

2003 ◽

Vol 78 (1) ◽

pp. 22-30 ◽

Cited By ~ 152

Author(s):

Sai Krupa Das ◽

Susan B Roberts ◽

Megan A McCrory ◽

LK George Hsu ◽

Scott A Shikora ◽

...

Keyword(s):

Weight Loss ◽

Gastric Bypass ◽

Body Composition ◽

Energy Expenditure ◽

Bypass Surgery ◽

Gastric Bypass Surgery ◽

Massive Weight Loss ◽

Long Term Changes

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Effect of Weight Loss by Gastric Bypass Surgery Versus Hypocaloric Diet on Glucose and Incretin Levels in Patients with Type 2 Diabetes

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2007-2851 ◽

2008 ◽

Vol 93 (7) ◽

pp. 2479-2485 ◽

Cited By ~ 485

Author(s):

Blandine Laferrère ◽

Julio Teixeira ◽

James McGinty ◽

Hao Tran ◽

Joseph R. Egger ◽

...

Keyword(s):

Type 2 Diabetes ◽

Weight Loss ◽

Gastric Bypass ◽

Bypass Surgery ◽

Gastric Bypass Surgery ◽

Oral Glucose ◽

Rapid Weight Loss ◽

Incretin Effect ◽

Equivalent Weight

Abstract Context: Gastric bypass surgery (GBP) results in rapid weight loss, improvement of type 2 diabetes (T2DM), and increase in incretins levels. Diet-induced weight loss also improves T2DM and may increase incretin levels. Objective: Our objective was to determine whether the magnitude of the change of the incretin levels and effect is greater after GBP compared with a low caloric diet, after equivalent weight loss. Design and Methods: Obese women with T2DM studied before and 1 month after GBP (n = 9), or after a diet-induced equivalent weight loss (n = 10), were included in the study. Patients from both groups were matched for age, body weight, body mass index, diabetes duration and control, and amount of weight loss. Setting: This outpatient study was conducted at the General Clinical Research Center. Main Outcome Measures: Glucose, insulin, proinsulin, glucagon, gastric inhibitory peptide (GIP), and glucagon-like peptide (GLP)-1 levels were measured after 50-g oral glucose. The incretin effect was measured as the difference in insulin levels in response to oral and to an isoglycemic iv glucose load. Results: At baseline, none of the outcome variables (fasting and stimulated values) were different between the GBP and diet groups. Total GLP-1 levels after oral glucose markedly increased six times (peak:17 ± 6 to 112 ± 54 pmol/liter; P < 0.001), and the incretin effect increased five times (9.4 ± 27.5 to 44.8 ± 12.7%; P < 0.001) after GBP, but not after diet. Postprandial glucose levels (P = 0.001) decreased more after GBP. Conclusions: These data suggest that early after GBP, the greater GLP-1 and GIP release and improvement of incretin effect are related not to weight loss but rather to the surgical procedure. This could be responsible for better diabetes outcome after GBP.

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Patients Lacking Sustainable Long-Term Weight Loss after Gastric Bypass Surgery Show Signs of Decreased Inhibitory Control of Prepotent Responses

PLoS ONE ◽

10.1371/journal.pone.0119896 ◽

2015 ◽

Vol 10 (3) ◽

pp. e0119896 ◽

Cited By ~ 5

Author(s):

Pleunie S. Hogenkamp ◽

Magnus Sundbom ◽

Victor C. Nilsson ◽

Christian Benedict ◽

Helgi B. Schiöth

Keyword(s):

Weight Loss ◽

Gastric Bypass ◽

Inhibitory Control ◽

Bypass Surgery ◽

Gastric Bypass Surgery ◽

Prepotent Responses

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Long-Term Weight Loss after Gastric Bypass Surgery. What Are the Predictors for Success?

Journal of Surgical Research ◽

10.1016/j.jss.2009.11.588 ◽

2010 ◽

Vol 158 (2) ◽

pp. 384

Author(s):

I. Leitman ◽

D. Edrich ◽

M. Bogart

Keyword(s):

Weight Loss ◽

Gastric Bypass ◽

Bypass Surgery ◽

Gastric Bypass Surgery

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Influence of the gastric stump’s volume on the long-term results of laparoscopic Roux-en-Y gastric bypass surgery

Grekov s Bulletin of Surgery ◽

10.24884/0042-4625-2021-180-1-81-88 ◽

2021 ◽

Vol 180 (1) ◽

pp. 81-88

Author(s):

A. G. Khitaryan ◽

D. A. Melnikov ◽

A. A. Orekhov ◽

A. V. Mezhunts ◽

S. A. Adizov ◽

...

Keyword(s):

Weight Loss ◽

Gastric Bypass ◽

Weight Gain ◽

Bypass Surgery ◽

Gastric Bypass Surgery ◽

Long Term Results ◽

Gastric Stump ◽

Insufficient Weight Loss

The objective was to retrospectively analyze the dependence of long-term results of laparoscopic Roux-en-Y gastric bypass surgery according to the size of the formed gastric stumpMethods and materials. We retrospectively analyzed the long-term results of 207 morbidly obese patients who underwent laparoscopic Roux-en-Y gastric bypass surgery by two different techniques. The median follow-up was 36 months. Two groups of patients were identified according to the method of formation of the gastric stump: using 2 (1st group) or 3 (2nd group) stapler cassettes and performing of computed tomography volumetry to determine thevolume of the created gastric stump.Results. Statistically significant differences in the volume of the formed gastric stump, depending on the method of operation, were as follows: 23.8 ml (8.9–37.3 ml) in the 1st group and 47.7 ml (31.9–72.8 ml) in the 2nd group (p<0.0001). Significant differences were observed in the following indicators: relapse of weight gain or insufficient weight loss (loss of < 70 % overweight) at median follow-up of 36 months were observed in 2 (2.3 %) and 12 (9.9 %) cases in the 1st and 2nd groups, respectively (p<0.05).Conclusion. We revealed that the formation of the gastric stump of a very small volume by 2 stapler cassettes compared to using 3 stapler cassettes contributes to improving the results in the long-term postoperative period and minimizing the frequency of relapse of weight gain and insufficient weight loss. The restrictive component of the surgery with equal malabsorptive is fundamental for the clinical parameters of its effectiveness, that leads to increasing the frequency of relapses of weight gain and insufficient weight loss in the 2nd group in comparison with the 1st and group of patients (p<0.05). Based on computed tomography volumetry, the volume of a small-sized stomach stump can be reliably measured and, accordingly, weight loss is predicted in the long term after the surgery, as well as the absence of relapses of weight gain or insufficient weight loss.

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