In this paper, the seismic collapse probability of base-isolated reinforced concrete buildings considering pounding with a moat wall and financial loss estimation is studied. For this purpose, three-dimensional finite element models of a code-compliant 10-story base-isolated shear wall-frame (BI-SWF) building and a 10-story base-isolated moment resisting frame (BI-MRF) building are used. Results indicate that the BI-MRF building has a greater probability of collapse compared to that of the BI-SWF building, the probability of collapse in 50 years for the BI-MRF building is 1.3 times greater than that of the BI-SWF building for both no pounding and pounding cases. The probability of collapse increases when pounding is considered, which results in a smaller value of the collapse margin ratio compared to no pounding case for both the buildings. The financial losses resulting from damage to the BI-MRF and BI-SWF buildings under design earthquake (DE) and risk-targeted maximum considered earthquake (MCER) levels are calculated for the no pounding case, since there was no pounding under DE-level and very few instances of pounding under MCER-level. Calculation of financial losses due to damage to structural and nonstructural components, service equipment and downtime shows that the BI-SWF building results in larger repair costs and downtime cost compared to the BI-MRF building.