:
Cannabidiol (CBD) is a non-psychotropic phytocannabinoid which represents one of the
constituents of the “phytocomplex” of Cannabis sativa. This natural compound is attracting growing
interest since when CBD-based remedies and commercial products were marketed. This review aims to
exhaustively address the extractive and analytical approaches that have been developed for the isolation
and quantification of CBD. Recent updates on cutting-edge technologies were critically examined in
terms of yield, sensitivity, flexibility and performances in general, and are reviewed alongside original
representative results. As an add-on to currently available contributions in the literature, the evolution
of the novel, efficient synthetic approaches for the preparation of CBD, a procedure which is appealing
for the pharmaceutical industry, is also discussed. Moreover, with the increasing interest on the therapeutic
potential of CBD and the limited understanding of the undergoing biochemical pathways, the
reader will be updated about recent in silico studies on the molecular interactions of CBD towards several
different targets attempting to fill this gap. Computational data retrieved from the literature have
been integrated with novel in silico experiments, critically discussed to provide a comprehensive and
updated overview on the undebatable potential of CBD and its therapeutic profile.
Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases
