Combined intraoperative administration of a histone deacetylase inhibitor and a neurokinin-1 receptor antagonist synergistically reduces intra-abdominal adhesion formation in a rat model

Adhesion Formation ◽

Neurokinin 1 Receptor ◽

Abdominal Adhesion ◽

Deacetylase Inhibitor ◽

Synergistic reduction of postoperative adhesions by combined intraoperative administration of a histone deacetylase inhibitor and a neurokinin-1 receptor antagonist is achieved by targeting different mechanisms in adhesiogenesis

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2012.06.079 ◽

2012 ◽

Vol 215 (3) ◽

pp. S22

Author(s):

Michael R. Cassidy ◽

Joseph J. Gallant ◽

Alan C. Sherburne ◽

Melanie L. Gainsbury ◽

Holly K. Sheldon ◽

...

Keyword(s):

Receptor Antagonist ◽

Histone Deacetylase ◽

Postoperative Adhesions ◽

Neurokinin 1 Receptor ◽

Deacetylase Inhibitor ◽

The Combined Intraoperative Administration of a Histone Deacetylase Inhibitor and a Neurokinin-1 Receptor Antagonist That Dramatically Reduces Postoperative Adhesions Downregulates Fibrin Pathways and Vascular Permeability

Journal of Surgical Research ◽

10.1016/j.jss.2012.10.156 ◽

2013 ◽

Vol 179 (2) ◽

pp. 190

Author(s):

M.R. Cassidy ◽

A.C. Sherburne ◽

A.F. Stucchi

Keyword(s):

Receptor Antagonist ◽

Vascular Permeability ◽

Histone Deacetylase ◽

Postoperative Adhesions ◽

Neurokinin 1 Receptor ◽

Deacetylase Inhibitor ◽

A neurokinin 1 receptor antagonist decreases adhesion reformation after laparoscopic lysis of adhesions in a rat model of adhesion formation

Surgical Endoscopy ◽

10.1007/s00464-007-9248-2 ◽

2007 ◽

Vol 21 (10) ◽

pp. 1790-1795 ◽

Cited By ~ 14

Author(s):

S. G. Prushik ◽

C. B. Aarons ◽

R. Matteotti ◽

K. L. Reed ◽

A. C. Gower ◽

...

Keyword(s):

Receptor Antagonist ◽

Rat Model ◽

Adhesion Formation ◽

Neurokinin 1 Receptor ◽

34: A Neurokinin-1 Receptor Antagonist (NK-1RA) That Reduces Intraabdominal Adhesion Formation Downregulates the Activation of the TGF-β1/Smad2 Signaling Pathway in a Rat Model

Journal of Surgical Research ◽

10.1016/j.jss.2008.11.051 ◽

2009 ◽

Vol 151 (2) ◽

pp. 186-187

Author(s):

R. Lim ◽

S. Heydrick ◽

D.I. Chu ◽

J.M. Morrill ◽

K.L. Reed ◽

...

Keyword(s):

Receptor Antagonist ◽

Signaling Pathway ◽

Rat Model ◽

Adhesion Formation ◽

Neurokinin 1 Receptor ◽

Neurokinin 1 ◽

Intraabdominal Adhesion ◽

Tgf Β1

QS483. A Neurokinin-1 Receptor Antagonist (NK-1RA) That Reduces Intraabdominal Adhesion Formation Upregulates Thrombospondin-1 Protein Expression Early in Adhesiogenesis in a Rat Model

Journal of Surgical Research ◽

10.1016/j.jss.2008.11.798 ◽

2009 ◽

Vol 151 (2) ◽

pp. 304

Author(s):

D.I. Chu ◽

R. Lim ◽

R.C. Lynch ◽

J.M. Morrill ◽

K.L. Reed ◽

...

Keyword(s):

Protein Expression ◽

Receptor Antagonist ◽

Rat Model ◽

Adhesion Formation ◽

Neurokinin 1 Receptor ◽

Thrombospondin 1 ◽

Neurokinin 1 ◽

Intraabdominal Adhesion

Sodium Butyrate, a Histone Deacetylase Inhibitor, Exhibits Neuroprotective/Neurogenic Effects in a Rat Model of Neonatal Hypoxia-Ischemia

Molecular Neurobiology ◽

10.1007/s12035-016-0049-2 ◽

2016 ◽

Vol 54 (7) ◽

pp. 5300-5318 ◽

Cited By ~ 27

Author(s):

Malgorzata Ziemka-Nalecz ◽

Joanna Jaworska ◽

Joanna Sypecka ◽

Rafał Polowy ◽

Robert K. Filipkowski ◽

...

Keyword(s):

Histone Deacetylase ◽

Sodium Butyrate ◽

Rat Model ◽

Neonatal Hypoxia ◽

Deacetylase Inhibitor ◽

Hypoxia Ischemia

A neurokinin-1 receptor antagonist that reduces intraabdominal adhesion formation increases peritoneal matrix metalloproteinase activity

Wound Repair and Regeneration ◽

10.1111/j.1524-475x.2007.00291.x ◽

2007 ◽

Vol 15 (6) ◽

pp. 800-808 ◽

Cited By ~ 14

Author(s):

Philip A. Cohen ◽

Adam C. Gower ◽

Arthur F. Stucchi ◽

Susan E. Leeman ◽

James M. Becker ◽

...

Keyword(s):

Matrix Metalloproteinase ◽

Receptor Antagonist ◽

Adhesion Formation ◽

Neurokinin 1 Receptor ◽

Neurokinin 1 ◽

Intraabdominal Adhesion ◽

Metalloproteinase Activity

1115 The Neuroprotective Effects of Valproic Acid, an Histone Deacetylase Inhibitor in a Neonatal Hypoxic-Ischemic Rat Model

Archives of Disease in Childhood ◽

10.1136/archdischild-2012-302724.1115 ◽

2012 ◽

Vol 97 (Suppl 2) ◽

pp. A320-A320

Author(s):

M. Cetinkaya ◽

T. Alkan ◽

M. Cansev ◽

Z. Minbay ◽

S. Serter ◽

...

Keyword(s):

Valproic Acid ◽

Histone Deacetylase ◽

Rat Model ◽

Neuroprotective Effects ◽

Deacetylase Inhibitor

Co-Administration of Valproic Acid (VPA), an Histone Deacetylase Inhibitor, and a Neurokinin-1 Receptor Antagonist (NK-1RA) that Reduces Intraabdominal Adhesion Formation in a Rat Surgical Model Downregulates the Expression of the Early Growth Response (Egr) Genes 1 and 3

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2014.07.024 ◽

2014 ◽

Vol 219 (3) ◽

pp. S15

Author(s):

Matthew T. Brady ◽

Elizabeth G. King ◽

Benjamin Keenan ◽

Stanley Heydrick ◽

Michael R. Cassidy ◽

...

Keyword(s):

Valproic Acid ◽

Growth Response ◽

Adhesion Formation ◽

Early Growth ◽

Early Growth Response ◽

Surgical Model ◽

Deacetylase Inhibitor ◽

Neurokinin 1 ◽

Intraabdominal Adhesion

The efficacy of a hyaluronate-carboxymethylcellulose bioresorbable membrane that reduces postoperative adhesions is increased by the intra-operative co-administration of a neurokinin 1 receptor antagonist in a rat model

Surgery ◽

10.1016/j.surg.2010.01.024 ◽

2010 ◽

Vol 148 (5) ◽

pp. 991-999 ◽

Cited By ~ 17

Author(s):

Rizal Lim ◽

Arthur F. Stucchi ◽

Jonathan M. Morrill ◽

Karen L. Reed ◽

Ryan Lynch ◽

...

Keyword(s):

Receptor Antagonist ◽

Rat Model ◽

Postoperative Adhesions ◽

Neurokinin 1 Receptor ◽

Bioresorbable Membrane ◽