An upper thoracic spinal cord tumor presenting as hemifacial hyperhidrosis

2007 ◽  
Vol 68 (4) ◽  
pp. 461-463 ◽  
Author(s):  
Cumhur Kilinçer ◽  
Levent Öztürk ◽  
M. Kemal Hamamcioglu ◽  
Emre Altunrende ◽  
Sebahattin Çobanoglu
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Tumor ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Upper Thoracic

Intramedullary canine spinal cord tumor model

1984 ◽  
Vol 61 (4) ◽  
pp. 761-766 ◽  
Author(s):  
Michael Salcman ◽  
Ernesto Botero ◽  
Krishna C. V. Rao ◽  
Richard D. Broadwell ◽  
Eric Scott
Keyword(s):  
Spinal Cord ◽  
Cell Suspension ◽  
Spinal Cord Tumor ◽  
Calf Serum ◽  
Tumor Model ◽  
Thoracic Spinal Cord ◽  
Content Type ◽  
Tumor Cell Suspension ◽  
Thoracic Spinal ◽  
Ethyl Cyanoacrylate

✓ The development of a transplantable model brain tumor in the neonatal dog, the adaptation of the tumor to tissue culture, and the successful growth of the tumor in adult mongrel dogs has been adapted to producing similar tumors in the thoracic spinal cord of the adult dog. Ten adult dogs, weighing 4 to 25.4 kg each, were subjected to formal laminectomy. The tumor cell suspension was injected by hand with a Hamilton syringe at two or three sites over a distance of 1 cm; each site received an injection volume to 0.02 to 0.05 cc of the cell suspension after the dura had been opened. Immediately after injection the field was copiously irrigated and the puncture area sealed with a single drop of ethyl cyanoacrylate. Tumor cells for injection were obtained by thawing ampules stored at −195°C in a mixture of 10% dimethyl sulfoxide and RPMI 1640 culture medium. Cells were resuspended in Hank's balanced salt solution and 15% fetal calf serum on ice. Solutions had 90% cell viability, and animals received a dose in the range of 3 to 13 × 106 cells. Eight animals developed tumors and became paraparetic on the 9th to 14th postinjection day. Metrizamide myelography in three animals revealed complete blocks; two animals underwent spinal computerized tomography (CT) and demonstrated syringohydromyelia. Histology revealed the tumors to be highly vascular primitive neoplasms that invaded the surrounding cord. This spinal cord tumor model is large enough to be operated on, studied by CT and myelography, and subjected to pharmacological, electrophysiological, and blood flow study.

scholarly journals Inexplicable Abdominal Pain due to Thoracic Spinal Cord Tumor

2014 ◽  
Vol 38 (2) ◽  
pp. 273 ◽  
Author(s):  
Jung Eun Park ◽  
Myung Eun Chung ◽  
Dae Heon Song ◽  
Hyun Sook Choi
Keyword(s):  
Spinal Cord ◽  
Abdominal Pain ◽  
Spinal Cord Tumor ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal

scholarly journals Upper thoracic spinal cord herniation after traumatic nerve root avulsion

2004 ◽  
Vol 16 (5) ◽  
pp. 306-309
Author(s):  
Victor R. DaSilva ◽  
Mubarak Al-Gahtany ◽  
Rajiv Midha ◽  
Dipanka Sarma ◽  
Perry Cooper
Keyword(s):  
Spinal Cord ◽  
Nerve Root ◽  
Signs And Symptoms ◽  
Root Avulsion ◽  
Thoracic Spinal Cord ◽  
First Case ◽  
Thoracic Spinal ◽  
Spinal Cord Herniation ◽  
Nerve Root Avulsion ◽  
Upper Thoracic

✓ Transdural herniation of the spinal cord, a rare but well-documented entity, has been reported sporadically for more than 25 years as a possible cause for various neurological signs and symptoms ranging from isolated sensory or motor findings to myelopathy and Brown–Séquard syndrome. The authors report, to the best of their knowledge, the first case of upper thoracic spinal cord herniation occurring after traumatic nerve root avulsion.

Upper Thoracic Spinal Cord Injury Without Vertebral Bony Lesion: A Report of Two Cases

Spine ◽  
2002 ◽  
Vol 27 (21) ◽  
pp. E467-E470 ◽  
Author(s):  
Munehisa Koizumi ◽  
Yurito Ueda ◽  
Jin Iida ◽  
Etsuhiro Matsuyama ◽  
Takafumi Yoshikawa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Cord Injury ◽  
Bony Lesion ◽  
Upper Thoracic

Intrathecal morphine analgesia after cervical and thoracic spinal cord tumor surgery

2014 ◽  
Vol 21 (6) ◽  
pp. 899-904 ◽  
Author(s):  
Beate Poblete ◽  
Christoph Konrad ◽  
Karl F. Kothbauer
Keyword(s):  
Spinal Cord ◽  
Intensive Care ◽  
Rating Scale ◽  
Intrathecal Morphine ◽  
Spinal Cord Tumor ◽  
Tumor Resection ◽  
Numeric Rating Scale ◽  
Thoracic Spinal Cord ◽  
Dural Closure ◽  
Thoracic Spinal

Object The aim of this study was to provide evidence for the effect of intrathecal morphine application after spinal cord tumor resection. Methods Twenty patients participated in a prospective open proof-of-concept study. During dural closure, morphine (7 μg/kg) was injected into the subarachnoid space. All patients were monitored in an intensive care setting postoperatively. Pain, additional opioids given, and vital parameters were recorded. Results Six patients received a mean morphine dose of 365 μg between C-3 and C-7 and 14 patients received a mean dose of 436 μg between T-2 and T-12. In the cervical and thoracic groups, the mean Numeric Rating Scale score was highest upon intensive care unit admission (1.2 and 2.5, respectively) and declined at 12 hours (0.5 and 0.8, respectively). Minimal extra morphine was required. Minor side effects occurred without consequence. Conclusions Intrathecal morphine for postoperative analgesia after resection of cervical and thoracic spinal cord tumors is effective and safe. These preliminary results require confirmation by larger comparative studies and further clinical experience.

scholarly journals Intermittent Atrioventricular Block following Fingolimod Initiation

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
E. Gialafos ◽  
S. Gerakoulis ◽  
A. Grigoriou ◽  
V. Haina ◽  
C. Kilidireas ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Atrioventricular Block ◽  
Frequency Domain Analysis ◽  
Thoracic Spinal Cord ◽  
Sympathetic Function ◽  
Thoracic Spinal ◽  
Demyelinating Lesions ◽  
Cardiac Sympathetic Function ◽  
Upper Thoracic

A 47-year-old female patient with multiple sclerosis (MS) developed symptomatic intermittent 2nd degree atrioventricular block (AVB) of five-hour duration, five hours after the first two doses of fingolimod, that resolved completely. Frequency domain analysis of heart rate variability (HRV) revealed increased parasympathetic activity and decreased sympathetic tone, while modified Ewing tests were suggestive of impaired cardiac sympathetic function. We hypothesize that expression of this particular arrhythmia might be related to autonomic nervous system (ANS) dysfunction due to demyelinating lesions in the upper thoracic spinal cord, possibly augmented by the parasympathetic effect of the drug.

scholarly journals The Preventive Effect of Cardiac Sympathetic Denervation Induced by 6-OHDA on Myocardial Ischemia–Reperfusion Injury: The Changes of lncRNA/circRNAs-miRNA-mRNA Network of the Upper Thoracic Spinal Cord in Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-28
Author(s):  
Zhixiao Li ◽  
Yujuan Li ◽  
Zhigang He ◽  
Zhen Li ◽  
Weiguo Xu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Sympathetic Denervation ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Myocardial Ischemia Reperfusion Injury ◽  
Myocardial Ischemia Reperfusion ◽  
Upper Thoracic ◽  
Cardiac Sympathetic Denervation

In this study, we investigated whether chemical 6-hydroxydopamine (6-OHDA) stimuli caused cardiac sympathetic denervation (SD), and we analyzed gene expression profiles to determine the changes in the lncRNA/circRNAs-miRNA-mRNA network in the affected spinal cord segments to identify putative target genes and molecular pathways in rats with myocardial ischemia–reperfusion injury (MIRI). Our results showed that cardiac sympathetic denervation induced by 6-OHDA alleviated MIRI. Compared with the ischemia reperfusion (IR, MIRI model) group, there were 148 upregulated and 51 downregulated mRNAs, 165 upregulated and 168 downregulated lncRNAs, 70 upregulated and 52 downregulated circRNAs, and 12 upregulated and 11 downregulated miRNAs in the upper thoracic spinal cord of the SD-IR group. Furthermore, we found that the differential genes related to cellular components were mainly enriched in extracellular and cortical cytoskeleton, and molecular functions were mainly enriched in chemokine activity. Pathway analysis showed that the differentially expressed genes were mainly related to the interaction of cytokines and cytokine receptors, sodium ion reabsorption, cysteine and methionine metabolism, mucoglycan biosynthesis, cGMP-PKG signaling pathway, and MAPK signaling pathway. In conclusion, the lncRNA/circRNAs-miRNA-mRNA networks in the upper thoracic spinal cord play an important role in the preventive effect of cardiac sympathetic denervation induced by 6-OHDA on MIRI, which offers new insights into the pathogenesis of MIRI and provides new targets for MIRI.

Vascular Leakage of Horseradish Peroxidase Following Acute Spinal Cord Injury

1973 ◽  
Vol 31 ◽  
pp. 654-655
Author(s):  
John L. Beggs ◽  
John D. Waggener
Keyword(s):  
Spinal Cord ◽  
Horseradish Peroxidase ◽  
Tight Junctions ◽  
Perivascular Spaces ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Cord Injury ◽  
Direct Penetration ◽  
Upper Thoracic ◽  
Low Rate

Under normal CNS conditions, circulating horseradish peroxidase (HRP) fails to enter the perivascular spaces due to the presence of interendothelial tight junctions and the absence or low rate of pinocytotic activity. Under some conditions where the blood brain barrier (BBB) is altered, HRP leakage occurs. Possible routes of HRP leakage include increased pinocytotic activity, breakdown of the interendothelial tight junctions, and direct penetration across severely damaged endothelial cells. The modes of leakage may vary with the type of insult.Following acute compression of upper thoracic spinal cord (cat), leakage and distribution of HRP is confined to the posterocentral gray matter with minimal involvement of white matter (Fig. 1).

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