2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the mRNA expression of critical genes associated with cholesterol metabolism, bile acid biosynthesis, and bile transport in rat liver: A microarray study

2005 ◽  
Vol 207 (1) ◽  
pp. 1-24 ◽  
Author(s):  
Nick Fletcher ◽  
David Wahlström ◽  
Rebecca Lundberg ◽  
Charlotte B. Nilsson ◽  
Kerstin C. Nilsson ◽  
...  
Keyword(s):  
Bile Acid ◽  
Mrna Expression ◽  
Rat Liver ◽  
Cholesterol Metabolism ◽  
Acid Biosynthesis ◽  
Bile Acid Biosynthesis ◽  
Microarray Study ◽  
Tetrachlorodibenzo P Dioxin

Effect of the hydroxyl group on the oxidative cleavage (β-oxidation) of steroidal side chain for bile acid biosynthesis in rat liver homogenate

Steroids ◽  
1997 ◽  
Vol 62 (6) ◽  
pp. 474-481 ◽  
Author(s):  
Takao Kurosawa ◽  
Masahiro Sato ◽  
Fumihiko Kikuchi ◽  
Takafumi Watanabe ◽  
Tetsuya Suga ◽  
...  
Keyword(s):  
Bile Acid ◽  
Rat Liver ◽  
Liver Homogenate ◽  
Oxidative Cleavage ◽  
Hydroxyl Group ◽  
Side Chain ◽  
Acid Biosynthesis ◽  
Bile Acid Biosynthesis

scholarly journals Bile Acid Biosynthesis Avoiding Cholesterol

2018 ◽  
Author(s):  
William J. Griffiths ◽  
Jonas Abdel-Khalik ◽  
Peter J. Crick ◽  
Eylan Yutuc ◽  
Michael Ogundare ◽  
...  
Keyword(s):  
Bile Acid ◽  
Cholesterol Metabolism ◽  
Cholesterol Biosynthesis ◽  
Liquid Chromatography Mass Spectrometry ◽  
Healthy Individuals ◽  
Acid Biosynthesis ◽  
Bile Acid Biosynthesis ◽  
Opitz Syndrome ◽  
A Minor ◽  
Minor Extent

AbstractBile acids are the end products of cholesterol metabolism secreted into bile. They are essential for the absorption of lipids and lipid soluble compounds from the intestine. Here we have investigated the bile acid content of plasma and urine from patients with a defect in cholesterol biosynthesis, i.e. Smith-Lemli-Opitz syndrome (SLOS), resulting in elevated levels of 7-dehydrocholesterol (7-DHC), an immediate precursor of cholesterol. Using liquid chromatography – mass spectrometry (LC-MS) we have identified a novel pathway of bile acid biosynthesis in SLOS avoiding cholesterol starting with 7-DHC. This pathway also proceeds to a minor extent in healthy individuals. Monitoring of the pathway products could provide a rapid diagnostic for SLOS while elevated levels of pathway intermediates could be responsible for some of the features of the disease. Importantly, intermediates in the pathway are modulators of the activity of Smoothened, an oncoprotein that mediates Hedgehog signalling during embryogenesis and regeneration of postembryonic tissue.

scholarly journals Activation of Bile Acid Biosynthesis by the p38 Mitogen-activated Protein Kinase (MAPK)

2007 ◽  
Vol 282 (34) ◽  
pp. 24607-24614 ◽  
Author(s):  
Zhumei Xu ◽  
Olga L. Tavares-Sanchez ◽  
Quanzhong Li ◽  
Josephine Fernando ◽  
Carmen M. Rodriguez ◽  
...  
Keyword(s):  
Bile Acid ◽  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Acid Biosynthesis ◽  
Bile Acid Biosynthesis ◽  
Mitogen Activated Protein
Sign in / Sign up

Export Citation Format

Share Document