Chrysin, an anti-inflammatory molecule, abrogates renal dysfunction in type 2 diabetic rats

2014 ◽  
Vol 279 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Amjid Ahad ◽  
Ajaz Ahmad Ganai ◽  
Mohd Mujeeb ◽  
Waseem Ahmad Siddiqui
2008 ◽  
Vol 23 (9) ◽  
pp. 2750-2760 ◽  
Author(s):  
G. J. Ko ◽  
Y. S. Kang ◽  
S. Y. Han ◽  
M. H. Lee ◽  
H. K. Song ◽  
...  

2018 ◽  
Vol 29 (5) ◽  
pp. 507-514 ◽  
Author(s):  
Abayomi Oluwatosin Ige ◽  
Olanrewaju Amos Ajayi ◽  
Eunice Olufunke Adewoye

Abstract Background Diabetes mellitus causes low-grade chronic inflammation which leads to the development of long-term complications. Oral magnesium (Mg) intake amongst other effects was reported to reduce the levels of inflammatory markers. This study investigated the anti-inflammatory and insulin secretory activities in experimental type-2 diabetic rats (n=32) orally treated with Mg. Methods Experimental type-2 diabetic rats were induced with high fat diet and alloxan (50 mg/kg, single i.p.) for over 10 weeks prior to the experimental procedures. Male Wistar rats were divided into 4 equal groups: control, untreated experimental diabetics, and experimental diabetics treated orally with either metformin (Met) (250 mg/kg), or Mg (250 mg/kg), respectively, for 14 days. The blood glucose (BG) levels were monitored before experimental induction of diabetes and thereafter on days 1, 7, 10, and 14, respectively. Serum insulin, C-reactive protein (CRP), interleukin-6 (IL-6), and lipid profile were assessed using laboratory kits while pancreatic beta cell function (BCF) and insulin resistance were estimated using homeostasis model assessment equations. Results Significant increase in the BG level was observed in all experimental diabetic groups on day 1 compared to controls. On day 14, BG, BCF, triglyceride, cholesterol, and low-density lipoprotein levels were increased while the high-density lipoprotein level was reduced in untreated diabetics compared to other groups. Insulin and insulin resistance were increased in all groups compared to control. Serum insulin and IL-6 were reduced while CRP was elevated in diabetic treated groups (Met and Mg) compared to untreated diabetics. Conclusions This study shows a hypoglycemic, lipid regulatory, insulin stimulatory, and anti-inflammatory effect of oral Mg treatment in experimental type-2 diabetic rats.


2018 ◽  
Vol 29 (5) ◽  
pp. 463-467 ◽  
Author(s):  
Zahra Arab Sadeghabadi ◽  
Nasrin Ziamajidi ◽  
Roghayeh Abbasalipourkabir ◽  
Roohollah Mohseni

Abstract Background Diabetic nephropathy and liver damage are important complications of diabetes mellitus (DM). Various factors, such as sirtuins (silent information regulators or SIRTs) are associated with these complications. Sirtuins are a family of NAD+-dependent proteins, and seven types of these can be found in mammalians. In this study, we evaluated the effects of aqueous garlic extract (G) on the expressions of SIRT1 and SIRT2 genes in the kidney and liver tissues of rats with types 1 and 2 diabetes. Methods A total of 36 male Wistar rats (230–280 g) were randomly divided into six groups: C: normal control rats, D1M: type 1 diabetic rats (induced with streptozotocin, STZ), D1M+G: type 1 diabetic rats that treated with garlic extract, D2M: type 2 diabetic rats (induced with STZ and niacinamide), D2M+G: type 2 diabetic rats treated with garlic extract, and G: normal rats that received garlic extract. At the end of the treatment time, kidney and liver tissue samples were collected from all rats. The SIRT1 and SIRT2 gene expressions were determined by qRT-PCR. Results The SIRT1 and SIRT2 gene expressions in the liver and kidney tissues of diabetic rats decreased significantly compared with those in the control rats (p<0.05). After treatment with garlic extract, the gene expressions also increased significantly compared with those in the diabetic rats and are close to normal level (p<0.05). Conclusions Garlic extract increased the SIRT1 and SIRT2 gene expressions in the livers and kidneys of diabetic rats. The antioxidant and anti-inflammatory effects of garlic have been proven in many studies. Thus, it is possible that garlic – with its effects on this pathway of gene expression – can have antioxidant and anti-inflammatory effects, thus decreasing diabetic complications.


2018 ◽  
Vol 108 ◽  
pp. 153-164 ◽  
Author(s):  
Hossein Azizian ◽  
Mohammad Khaksari ◽  
Gholamreza Asadi karam ◽  
Mansour Esmailidehaj ◽  
Zeinab Farhadi

2006 ◽  
Vol 17 (5) ◽  
pp. 1362-1372 ◽  
Author(s):  
Sang-Youb Han ◽  
Cy-Hyun Kim ◽  
Han-Seong Kim ◽  
Yi-Hwa Jee ◽  
Hye-Kyoung Song ◽  
...  

Biochimie ◽  
2014 ◽  
Vol 106 ◽  
pp. 101-110 ◽  
Author(s):  
Amjid Ahad ◽  
Mohd Mujeeb ◽  
Haseeb Ahsan ◽  
Waseem Ahmad Siddiqui

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