Application of electroretinography (ERG) in early drug development for assessing retinal toxicity in rats

2015 ◽  
Vol 289 (3) ◽  
pp. 525-533 ◽  
Author(s):  
Wenhu Huang ◽  
Walter Collette ◽  
Michelle Twamley ◽  
Shirley A. Aguirre ◽  
Aida Sacaan
Keyword(s):  
Drug Development ◽  
Retinal Toxicity ◽  
Early Drug

scholarly journals Development of a small-scale spray-drying approach for amorphous solid dispersions (ASDs) screening in early drug development

2018 ◽  
Vol 24 (5) ◽  
pp. 560-574 ◽  
Author(s):  
Aymeric Ousset ◽  
Céline Bassand ◽  
Pierre-François Chavez ◽  
Joke Meeus ◽  
Florent Robin ◽  
...  
Keyword(s):  
Drug Development ◽  
Spray Drying ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Small Scale ◽  
Amorphous Solid Dispersions ◽  
Early Drug

scholarly journals Evaluation of the relevance of DILI predictive hypotheses in early drug development: review of in vitro methodologies vs. BDDCS classification

2018 ◽  
Vol 7 (3) ◽  
pp. 358-370 ◽  
Author(s):  
Rosa Chan ◽  
Leslie Z. Benet
Keyword(s):  
Liver Injury ◽  
Drug Development ◽  
Safety Concern ◽  
Drug Induced ◽  
Development Review ◽  
Drug Induced Liver Injury ◽  
Underlying Mechanisms ◽  
Early Drug

Drug-induced liver injury (DILI) is a major safety concern; it occurs frequently; it is idiosyncratic; it cannot be adequately predicted; and a multitude of underlying mechanisms has been postulated.

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