compound 2-((1H-benzo[d]imidazol-2-yl)thio)acetic acid (1) with o-aminobenzamide (2) gave compound (2-[1-(1H-benzimidazol-2-yl)-ethylsulfanyl]-3H-quinazolin-4-one (3). 3 could also be syntehsized by an alternative two routes scheme 2 and scheme 3. It appears from scheme 3 that it is giving good yields under green and eco-friendly conditions using PEG-600 (polyethylent glycol). Compound 10 was synthesized in two routes scheme4 and scheme 5. It appears from Route B (Scheme 4) that it is giving good yields: alkylation followed by oxidation in route A followed by alkylation in PEG-600 used as a green solvent. The total sequence of reactions has been carried out using eco-friendly and green conditions. Further, anticancer activity was carried out by using docking studies and binding conformation of active compounds of 3, 8, 9 and 10. The results show that 3 and 9 have potential to be developed as chemotherapeutic agents and compounds 3, 9 molecule showed best fit, potent dock score when compared with doxorubicin.
The green synthesis of 2,3-dihydroquinazolin-4(1H)-ones via direct cyclocondensation reaction under catalyst-free conditions