A short, rapid synthesis of heliannuol D, an allelochemical from Helianthus annus employing ring-closing metathesis

2004 ◽  
Vol 45 (10) ◽  
pp. 2047-2048 ◽  
Author(s):  
Subir K. Sabui ◽  
Ramanathapuram V. Venkateswaran
Keyword(s):  
Ring Closing Metathesis ◽  
Rapid Synthesis ◽  
Helianthus Annus

A Rapid Synthesis of Hexofuranose-like Iminosugars Using Ring-Closing Metathesis

2005 ◽  
Vol 7 (16) ◽  
pp. 3521-3523 ◽  
Author(s):  
Sylvaine Cren ◽  
Claire Wilson ◽  
Neil R. Thomas
Keyword(s):  
Ring Closing Metathesis ◽  
Rapid Synthesis

Carbohydrates as versatile platforms in the construction of small compound libraries

2005 ◽  
Vol 77 (7) ◽  
pp. 1173-1181 ◽  
Author(s):  
Mattie S. M. Timmer ◽  
Steven H. L. Verhelst ◽  
Gijsbert M. Grotenbreg ◽  
Mark Overhand ◽  
Herman S. Overkleeft
Keyword(s):  
Antibacterial Activity ◽  
Solid Phase ◽  
Building Blocks ◽  
Peptide Mimetics ◽  
Carbohydrate Chemistry ◽  
Ring Closing Metathesis ◽  
Rapid Synthesis ◽  
Small Compound ◽  
Compound Libraries ◽  
Three Component Reaction

This paper presents our recent results concerning the use of carbohydrates as cheap, chiral, and enantiopure starting materials in the construction of a variety of densely functionalized molecules. The compatibility of ring-closing metathesis with standard carbohydrate chemistry is demonstrated in the synthesis of new stereoisomers of deoxystreptamine and neamine–important building blocks for the generation of synthetic aminoglycosides with potential antibacterial activity. Ring-closing metathesis is also a key step in the rapid synthesis of new indolizidines and quinolizidines, and in a new solid-phase assisted carbohydrate-based combinatorial scaffold strategy. Further, some of our latest results in the conformational analysis of sugar amino acid-based peptide mimetics and in the development of a novel Ugi-type three-component reaction of sugar-derived azido-aldehydes are discussed.

Modified Solid-Phase Methods for the Rapid Synthesis of Opioid Peptides

1991 ◽  
Author(s):  
Richard A. Houghten ◽  
◽  
John M. Ostresh ◽  
Suzanne M. Pratt
Keyword(s):  
Opioid Peptides ◽  
Solid Phase ◽  
Rapid Synthesis

Exogenous Directing Group Free, Ligand-Enabled gamma-C(sp3)–H Arylation of Free Primary Aliphatic Amines and α-Amino Esters

2019 ◽  
Author(s):  
Yongzheng Ding ◽  
Shuai Fan ◽  
Xiaoxi Chen ◽  
yuzhen gao ◽  
Gang Li
Keyword(s):  
Amino Acids ◽  
Large Scale ◽  
Free Ligand ◽  
Aliphatic Amines ◽  
Rapid Synthesis ◽  
Amino Esters ◽  
Directing Group ◽  
Large Scale Synthesis ◽  
Primary Aliphatic Amines

A Pdᴵᴵ-catalyzed, ligand-enabled gamma-C(sp3)–H arylation of free primary aliphatic amines and amino esters without using an exogenous directing group is reported. This reaction is compatible with unhindered free aliphatic amines, and it is also be applicable to the rapid synthesis of biologically and synthetically valuable unnatural α-amino acids. Large scale synthesis is also feasible using this method.<br>

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