Mild one-pot conversion of carboxylic acids to amides or esters with Ph3P/trichloroisocyanuric acid

2005 ◽  
Vol 46 (35) ◽  
pp. 5945-5947 ◽  
Author(s):  
Rogério da C. Rodrigues ◽  
Igor M.A. Barros ◽  
Edson L.S. Lima
Keyword(s):  
Carboxylic Acids ◽  
One Pot ◽  
Trichloroisocyanuric Acid

Mild One-Pot Conversion of Carboxylic Acids to Amides or Esters with Ph3P/Trichloroisocyanuric Acid.

ChemInform ◽  
2005 ◽  
Vol 36 (49) ◽  
Author(s):  
Rogerio da C. Rodrigues ◽  
Igor M. A. Barros ◽  
Edson L. S. Lima
Keyword(s):  
Carboxylic Acids ◽  
One Pot ◽  
Trichloroisocyanuric Acid

Ultrasound-Assisted Synthesis of N-Acylcyanamides and N-Acyl-Substituted Imidazolones from Carboxylic Acids by Using Trichloroisocyanuric Acid/Triphenylphosphine

Synlett ◽  
2020 ◽  
Vol 31 (07) ◽  
pp. 703-707
Author(s):  
Wong Phakhodee ◽  
Dolnapa Yamano ◽  
Mookda Pattarawarapan
Keyword(s):  
Carboxylic Acids ◽  
Room Temperature ◽  
One Pot ◽  
One Pot Synthesis ◽  
Ultrasound Assisted ◽  
Trichloroisocyanuric Acid

A convenient ultrasound-assisted one-pot synthesis of N-acylcyanamides starting from readily available carboxylic acids and sodium cyanamide has been developed. Upon activation in the presence of trichloroisocyanuric acid (TCCA) and triphenylphosphine, a range of carboxylic acids was converted into N-acylcyanamides in good to excellent yields within 10 minutes at room temperature without base. Remarkably, N-acyl-substituted imidazolones were readily accessible through guanylation-cyclization of the in situ generated N-acylcyanamides.

Synthesis of 3-(Cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8- carboxylic Acids Via an Efficient Three-component Condensation Reaction between Cyclohexylisocyanide and 2-Aminopyridine-3-carboxylic Acid in the Presence of Aromatic Aldehyde

2018 ◽  
Vol 21 (4) ◽  
pp. 298-301 ◽  
Author(s):  
Ghasem Marandi
Keyword(s):  
Biological Sciences ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
High Performance ◽  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
New Materials ◽  
One Pot ◽  
High Yields ◽  
Benzaldehyde Derivatives

Aim and Objective: The reaction of cyclohexylisocyanide and 2-aminopyridine-3- carboxylic acid in the presence of benzaldehyde derivatives in ethanol led to 3-(cyclohexylamino)-2- arylimidazo[1,2-a]pyridine-8-carboxylic acids in high yields. In a three component condensation reaction, isocyanide reacts with 2-aminopyridine-3-carboxylic acid and aromatic aldehydes without any prior activation. Material and Methods: The synthesized products have stable structures which have been characterized by IR, 1H, 13C and Mass spectroscopy as well as CHN-O analysis. Results: In continuation of our attempts to develop simple one-pot routes for the synthesis of 3- (cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids, aromatic aldehydes with divers substituted show a high performance. Conclusion: In conclusion, this study introduces the art of combinatorial chemistry using a simple one-pot procedure for the synthesis of new materials which are interesting compounds in medicinal and biological sciences.

Amides in One Pot from Carboxylic Acids and Amines via Sulfinylamides

2014 ◽  
Vol 16 (2) ◽  
pp. 604-607 ◽  
Author(s):  
Jianfei Bai ◽  
Bartosz K. Zambroń ◽  
Pierre Vogel
Keyword(s):  
Carboxylic Acids ◽  
One Pot

A MILD, ONE-POT METHOD FOR THE CONVERSION OF CARBOXYLIC ACIDS INTO THE CORRESPONDING WEINREB AMIDES

2001 ◽  
Vol 31 (13) ◽  
pp. 2011-2019 ◽  
Author(s):  
Martin Banwell ◽  
Jason Smith
Keyword(s):  
Carboxylic Acids ◽  
One Pot ◽  
Weinreb Amides

Transition metal-free, NaOtBu-O2-mediated one-pot cascade oxidation of allylic alcohols to α,β-unsaturated carboxylic acids

2012 ◽  
Vol 14 (11) ◽  
pp. 2996 ◽  
Author(s):  
Sun Min Kim ◽  
Young Sug Kim ◽  
Dong Wan Kim ◽  
Jung Woon Yang
Keyword(s):  
Transition Metal ◽  
Carboxylic Acids ◽  
Allylic Alcohols ◽  
One Pot ◽  
Metal Free ◽  
Unsaturated Carboxylic Acids

Solvent-free, one-pot synthesis of 2,4,6-triarylpyridines using trichloroisocyanuric acid or N-bromosuccinimide as a novel and neutral catalyst

2011 ◽  
Vol 76 (11) ◽  
pp. 1307-1315 ◽  
Author(s):  
Behrooz Maleki ◽  
Hafezeh Salehabadi ◽  
Zeinalabedin Sepehr ◽  
Mina Kermanian
Keyword(s):  
Ammonium Acetate ◽  
Solvent Free ◽  
One Pot ◽  
Aryl Aldehydes ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Trichloroisocyanuric Acid

A simple and benign protocol has been explored for the preparation of 2,4,6-triarylpyridines by a one-pot reaction between aryl aldehydes, enolizable ketones and ammonium acetate in the presence of N-bromosuccinimide or trichloroisocyanuric acid as green and neutral catalysts. The reactions proceed smoothly at 130 °C under solvent-free conditions to provide 2,4,6-triarylpyridines in good yields.

ChemInform Abstract: Synthetic Study on the T3P®-Promoted One-Pot Preparation of 1-Substituted-3,4-dihydro-β-carbolines by the Reaction of Tryptamine with Carboxylic Acids.

ChemInform ◽  
2016 ◽  
Vol 47 (33) ◽  
Author(s):  
Peter Abranyi-Balogh ◽  
Tamas Foeldesi ◽  
Alajos Gruen ◽  
Balazs Volk ◽  
Gyoergy Keglevich ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
One Pot
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