An efficient, inexpensive and environmentally friendly synthesis of novel isoxazole substituted spirooxindole-pyridopyrimidine/indenopyridine/chromenopyridine/naphthyridine/quinoline derivatives has been developed.
A simple and benign one-pot protocol for the synthesis of 2-amino selenopyrindine derivatives 4 has been developed using ultrasound assisted multicomponent reactions of aldehydes, malononitrile and benzeneselenol in PEG-400.