scholarly journals Tandem oxidation–Wittig reaction using nanocrystalline barium manganate (BaMnO4); an improved one-pot protocol

2016 ◽  
Vol 57 (33) ◽  
pp. 3773-3775 ◽  
Author(s):  
Mohammad Gholinejad ◽  
Habib Firouzabadi ◽  
Maedeh Bahrami ◽  
Carmen Nájera
Keyword(s):  
Wittig Reaction ◽  
One Pot

One-Pot Synthesis of 3-(1,2,3,4-Tetrahydroisoquinolin-1-yl)-isoquinolin-1(2H)-ones by Sequential DEAD-Promoted Oxidative Ugi/Wittig Reaction Starting from Phosphonium Salt Precursors

Synlett ◽  
2021 ◽  
Author(s):  
Long Zhao ◽  
Mao-Lin Yang ◽  
Mei Sun ◽  
Ming-Wu Ding
Keyword(s):  
Wittig Reaction ◽  
Phosphonium Salt ◽  
One Pot ◽  
One Pot Synthesis ◽  
Sequential Reactions

A new one-pot Synthesis of 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)- isoquinolin-1(2H)-ones by DEAD-promoted oxidative Ugi/Wittig reaction was developed. The sequential reactions of (2-carboxybenzyl)triphenylphosphonium salts, isocyanides and N-aryl-1,2,3,4-tetrahydroisoquinolines produced 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)- isoquinolin-1(2H)-ones in moderate to good overall yields in the presence of DEAD and Et3N.

DEAD-Mediated Oxidative Ugi/Aza-Wittig Reaction for the Synthesis of 5-(1,2,3,4-Tetrahydroisoquinolin-1-yl)-1,3,4-oxadi­­azoles Starting from (N-Isocyanimine)triphenylphosphorane

Synthesis ◽  
2020 ◽  
Author(s):  
Ming-Wu Ding ◽  
Mei Sun ◽  
Long Zhao ◽  
Yan-Ling Yu
Keyword(s):  
Carboxylic Acids ◽  
Wittig Reaction ◽  
One Pot

AbstractA one-pot protocol for the synthesis of 5-(1,2,3,4-tetra­hydroisoquinolin-1-yl)-1,3,4-oxadiazoles via DEAD-mediated oxidative Ugi/aza-Wittig reaction has been developed. The reaction of (N-iso­cyanimine)triphenylphosphorane, carboxylic acids, and N-aryl-1,2,3,4-tetrahydroisoquinolines produced polysubstituted 5-(1,2,3,4-tetra­hydroisoquinolin-1-yl)-1,3,4-oxadiazoles directly in good yields in the presence of DEAD as an oxidant.

scholarly journals Synthesis and Antioxidant Activity of Caffeic Acid Derivatives

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2199 ◽  
Author(s):  
Katarzyna Sidoryk ◽  
Anna Jaromin ◽  
Nina Filipczak ◽  
Piotr Cmoch ◽  
Marcin Cybulski
Keyword(s):  
Organic Chemistry ◽  
Antioxidant Activity ◽  
Caffeic Acid ◽  
Wittig Reaction ◽  
Hydroxyl Group ◽  
Hydroxyl Groups ◽  
Water Medium ◽  
One Pot ◽  
Safe Alternative ◽  
Caffeic Acid Derivatives

A series of caffeic acid derivatives were synthesized via a modified Wittig reaction which is a very important tool in organic chemistry for the construction of unsaturated carbon–carbon bonds. All reactions were performed in water medium at 90 °C. The aqueous Wittig reaction worked best when one unprotected hydroxyl group was present in the phenyl ring. The olefinations in the aqueous conditions were also conducted with good yields in the presence of two unprotected hydroxyl groups. When the number of the hydroxyl groups was increased to three, the reaction yields were worse, and the derivatives 12, 13, and 18 were obtained with 74%, 37%, and 70% yields, respectively. Nevertheless, the Wittig reaction using water as the essential medium is an elegant one-pot synthesis and a greener method, which can be a safe alternative for implementation in organic chemistry. The obtained compounds were tested for their antioxidant activity, and 12, 13, and 18 showed the highest activities. Moreover, all synthesized compounds displayed no cytotoxicity, and can therefore be used in the pharmaceutical or cosmetic industry.

ChemInform Abstract: One-Pot Process in Phosphonium-Iodonium Ylides: Nucleophilic Substitution and the Wittig Reaction.

ChemInform ◽  
2010 ◽  
Vol 41 (8) ◽  
Author(s):  
E. D. Matveeva ◽  
T. A. Podrugina ◽  
A. S. Pavlova ◽  
A. V. Mironov ◽  
N. S. Zefirov
Keyword(s):  
Nucleophilic Substitution ◽  
Wittig Reaction ◽  
One Pot ◽  
Iodonium Ylides

scholarly journals One-pot sequential synthesis of isocyanates and urea derivatives via a microwave-assisted Staudinger–aza-Wittig reaction

2013 ◽  
Vol 9 ◽  
pp. 2378-2386 ◽  
Author(s):  
Diego Carnaroglio ◽  
Katia Martina ◽  
Giovanni Palmisano ◽  
Andrea Penoni ◽  
Claudia Domini ◽  
...  
Keyword(s):  
Wittig Reaction ◽  
Scale Up ◽  
Alkyl Halides ◽  
Secondary Amines ◽  
Nucleophilic Substitutions ◽  
One Pot ◽  
Urea Derivatives ◽  
Step Process ◽  
Microwave Assisted ◽  
Simple Filtration

A fast and efficient protocol for the synthesis of N,N'-disubstituted urea derivatives from alkyl halides and primary or secondary amines has been developed. The synthetic pathway combines nucleophilic substitutions and a Staudinger–aza-Wittig reaction in the presence of polymer-bound diphenylphosphine under 14 bar of CO2 pressure and has been performed in a one-pot two-step process. The protocol has been optimized under microwave irradiation and the scale-up experiment has been conducted under conventional conditions in a Parr reactor. The final compounds were isolated after simple filtration in almost quantitative overall yields which makes this procedure facile and rapid to execute.

ChemInform Abstract: Combination of C=C Bond Formation by Wittig Reaction and Enzymatic C=C Bond Reduction in a One-Pot Process in Water.

ChemInform ◽  
2011 ◽  
Vol 42 (21) ◽  
pp. no-no
Author(s):  
Marina Krausser ◽  
Till Winkler ◽  
Nina Richter ◽  
Sabine Dommer ◽  
Anja Fingerhut ◽  
...  
Keyword(s):  
Wittig Reaction ◽  
Bond Formation ◽  
One Pot

Combination of CC Bond Formation by Wittig Reaction and Enzymatic CC Bond Reduction in a One-Pot Process in Water

ChemCatChem ◽  
2011 ◽  
Vol 3 (2) ◽  
pp. 293-296 ◽  
Author(s):  
Marina Kraußer ◽  
Till Winkler ◽  
Nina Richter ◽  
Sabine Dommer ◽  
Anja Fingerhut ◽  
...  
Keyword(s):  
Wittig Reaction ◽  
Bond Formation ◽  
One Pot
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