Cervical changes in estrogen receptor alpha, oxytocin receptor, LH receptor, and cyclooxygenase-2 depending on the histologic compartment, longitudinal axis, and day of the ovine estrous cycle

2014 ◽  
Vol 81 (6) ◽  
pp. 813-824 ◽  
Author(s):  
M. Rodríguez-Piñón ◽  
R. Gonzalez ◽  
C. Tasende ◽  
A. Bielli ◽  
P. Genovese ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrous Cycle ◽  
Estrogen Receptor Alpha ◽  
Longitudinal Axis ◽  
Oxytocin Receptor ◽  
Cyclooxygenase 2 ◽  
Lh Receptor ◽  
Receptor Alpha

scholarly journals Computer-Aided Drug Repurposing: A Cyclooxygenase-2 Inhibitor Celecoxib as a Ligand for Estrogen Receptor Alpha

2015 ◽  
Vol 15 (3) ◽  
pp. 274-280 ◽  
Author(s):  
Enade Perdana Istyastono ◽  
Florentinus Dika Octa Riswanto ◽  
Sri Hartati Yuliani
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
In Silico ◽  
Estrogen Receptor Alpha ◽  
Cyclooxygenase 2 ◽  
Cytotoxic Activities ◽  
In Vitro Test ◽  
Receptor Alpha ◽  
Vitro Test

A cyclooxygenase-2 (COX-2) inhibitor celecoxib has been previously reported to have cytotoxic activities towards gastric, prostate, ovarian, colon and breast cancer cell lines. This article reports that the cytotoxic activities of celecoxib could be resulted from its activity as a potent ligand for estrogen receptor alpha (ERα). Aided by molecular docking simulations, an in silico test to examine whether celecoxib is a ligand for estrogen receptor alpha (ERα) was performed followed by in vitro test employing cytotoxic assay using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) method. The compound was extracted from Celebrex®. Measured by using UV spectrophotometric method at 255.5 nm, it was identified that the content of celecoxib was 102.15 mg/271.48 mg capsule content. The in silico test indicated that celecoxib is a potent ligand for ERα. This finding was confirmed experimentally by an in vitro test that celecoxib has a comparable activity as an ERα ligand to tamoxifen, a drug of choice for breast cancer treatment.

Modulation of cardiac oxytocin receptor and estrogen receptor alpha mRNAs expression following neonatal oxytocin treatment

Endocrine ◽  
2007 ◽  
Vol 31 (2) ◽  
pp. 154-160 ◽  
Author(s):  
Hossein Pournajafi-Nazarloo ◽  
Eros Papademeteriou ◽  
Leila Partoo ◽  
Habibollah Saadat ◽  
Bruce S. Cushing
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Alpha ◽  
Oxytocin Receptor ◽  
Receptor Alpha

Estrogen receptor alpha (ERα) and progesterone receptor (PR) in the mammary gland of bitches during different stages of estrous cycle

2009 ◽  
Vol 19 (2) ◽  
pp. 173-178
Author(s):  
Sukanya Manee-in ◽  
Sayamon Srisuwatanasagul ◽  
Chainarong Lohachit ◽  
Junpen Suwimonteerabutr ◽  
Sudson Sirivaidyapong
Keyword(s):  
Estrogen Receptor ◽  
Mammary Gland ◽  
Progesterone Receptor ◽  
Estrous Cycle ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha

scholarly journals CHANGES IN THE NUMBER OF ESTROGEN RECEPTOR ALPHA AND BETA IMMUNOREACTIVE CELLS ON POAAHA DURING THE ESTROUS CYCLE OF THE RAT

2007 ◽  
Vol 77 (Suppl_1) ◽  
pp. 106-106
Author(s):  
Luciano Mendoza-Garces ◽  
Paola Artega-Lopez ◽  
Roberto Domínguez ◽  
Marco Cerbon ◽  
Isabel Arrieta-Cruz ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrous Cycle ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha
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