Effects of Porcine bone marrow-derived Platelet-Rich Plasma on bone marrow-derived mesenchymal stem cells and endothelial progenitor cells

2021 ◽  
pp. 101587
Author(s):  
Lei Shi ◽  
Boon Ching Tee ◽  
Zongyang Sun
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Platelet Rich Plasma ◽  
Endothelial Progenitor

scholarly journals Recent Advances in Mono- and Combined Stem Cell Therapies of Stroke in Animal Models and Humans

2019 ◽  
Vol 20 (23) ◽  
pp. 6029 ◽  
Author(s):  
Surugiu ◽  
Olaru ◽  
Hermann ◽  
Glavan ◽  
Catalin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Animal Models ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Brain Plasticity ◽  
Human Umbilical Cord ◽  
Endothelial Progenitor

Following the failure of acute neuroprotection therapies, major efforts are currently made worldwide to promote neurological recovery and brain plasticity in the subacute and post-acute phases of stroke. Currently, there is hope that stroke recovery might be promoted by cell-based therapies. The field of stem cell therapy for cerebral ischemia has made significant progress in the last five years. A variety of stem cells have been tested in animal models and humans including adipose stem cells, human umbilical cord blood-derived mesenchymal stem cells, human amnion epithelial cells, human placenta amniotic membrane-derived mesenchymal stem cells, adult human pluripotent-like olfactory stem cells, human bone marrow endothelial progenitor cells, electrically-stimulated human neuronal progenitor cells, or induced pluripotent stem cells (iPSCs) of human origin. Combination therapies in animal models include a mix of two or more therapeutic factors consisting of bone marrow stromal cells, exercise and thyroid hormones, endothelial progenitor cells overexpressing the chemokine CXCL12. Mechanisms underlying the beneficial effects of transplanted cells include the “bystander” effects, paracrine mechanisms, or extracellular vesicles-mediated restorative effects. Mitochondria transfer also appears to be a powerful strategy for regenerative processes. Studies in humans are currently limited to a small number of studies using autologous stem cells mainly aimed to assess tolerability and side-effects of human stem cells in the clinic.

scholarly journals The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification

2020 ◽  
Vol 21 (7) ◽  
pp. 2466 ◽  
Author(s):  
Yi-Chou Hou ◽  
Chien-Lin Lu ◽  
Cai-Mei Zheng ◽  
Wen-Chih Liu ◽  
Tzung-Hai Yen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Vitamin D ◽  
Mesenchymal Stem Cells ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Vascular Calcification ◽  
Osteoblastic Differentiation ◽  
Endothelial Progenitor

Vascular calcification, which involves the deposition of calcifying particles within the arterial wall, is mediated by atherosclerosis, vascular smooth muscle cell osteoblastic changes, adventitial mesenchymal stem cell osteoblastic differentiation, and insufficiency of the calcification inhibitors. Recent observations implied a role for mesenchymal stem cells and endothelial progenitor cells in vascular calcification. Mesenchymal stem cells reside in the bone marrow and the adventitial layer of arteries. Endothelial progenitor cells that originate from the bone marrow are an important mechanism for repairing injured endothelial cells. Mesenchymal stem cells may differentiate osteogenically by inflammation or by specific stimuli, which can activate calcification. However, the bioactive substances secreted from mesenchymal stem cells have been shown to mitigate vascular calcification by suppressing inflammation, bone morphogenetic protein 2, and the Wingless-INT signal. Vitamin D deficiency may contribute to vascular calcification. Vitamin D supplement has been used to modulate the osteoblastic differentiation of mesenchymal stem cells and to lessen vascular injury by stimulating adhesion and migration of endothelial progenitor cells. This narrative review clarifies the role of mesenchymal stem cells and the possible role of vitamin D in the mechanisms of vascular calcification.

Correlation Between Melanoma Angiogenesis and the Mesenchymal Stem Cells and Endothelial Progenitor Cells Derived from Bone Marrow

2005 ◽  
Vol 14 (3) ◽  
pp. 292-298 ◽  
Author(s):  
Baocun Sun ◽  
Shiwu Zhang ◽  
Chunsheng Ni ◽  
Danfang Zhang ◽  
Yanxue Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor

Composite implantation of mesenchymal stem cells with endothelial progenitor cells enhances tissue-engineered bone formation

2009 ◽  
Vol 90A (3) ◽  
pp. 730-741 ◽  
Author(s):  
Kazutada Usami ◽  
Hirokazu Mizuno ◽  
Kunihiko Okada ◽  
Yuji Narita ◽  
Mika Aoki ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Formation ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor
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