Determination of morphologic and immunohistochemical stain (p57 kip2) discrepancy of complete and partial hydatidiform mole by using microsatellite genotyping

Context.—Molecular genotyping by analysis of DNA microsatellites, also known as short tandem repeats (STRs), is an established method for diagnosing and classifying hydatidiform mole. Distinction of both complete hydatidiform mole and partial hydatidiform mole from nonmolar specimens is relevant for clinical management owing to differences in risk for persistent gestational trophoblastic disease. Objective.—To determine the technical performance of microsatellite genotyping by using a commercially available multiplex assay, and to describe the application of additional methods to confirm other genetic abnormalities detected by the genotyping assay. Design.—Microsatellite genotyping data on 102 cases referred for molar pregnancy testing are presented. A separate panel of mini STR markers, flow cytometry, fluorescence in situ hybridization, and p57 immunohistochemistry were used to characterize cases with other incidental genetic abnormalities. Results.—Forty-eight cases were classified as hydatidiform mole (31, complete hydatidiform mole; 17, partial hydatidiform mole). Genotyping also revealed 11 cases of suspected trisomy and 1 case of androgenetic/biparental mosaicism. Trisomy for selected chromosomes (13, 16, 18, and 21) was confirmed in all cases by using a panel of mini STR markers. Conclusions.—This series illustrates the utility of microsatellite genotyping as a stand-alone method for accurate classification of hydatidiform mole. Other genetic abnormalities may be detected by genotyping; confirmation of the suspected abnormality requires additional testing.

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A Case of Invasive Mole

Faridpur Medical College Journal ◽

10.3329/fmcj.v12i2.34236 ◽

2017 ◽

Vol 12 (2) ◽

pp. 86-87

Author(s):

Shahana Ahmed ◽

Dipti Rani Shaha

Keyword(s):

Hydatidiform Mole ◽

The Body ◽

Emergency Laparotomy ◽

Molar Pregnancy ◽

Complete Hydatidiform Mole ◽

Partial Hydatidiform Mole ◽

Normal Limits ◽

History Of ◽

Invasive Mole

Invasive mole is a condition where a molar pregnancy, such as a partial hydatidiform mole or complete hydatidiform mole, invades the wall of the uterus, potentially spreading and metastasizing to other parts of the body. Here is a case who presented with history of evacuation for molar pregnancy. She presented with irregular P/V bleeding on and off and after admission silent perforation with massive haemoperitoneum was detected for which emergency laparotomy was done. She recovered and was followed up till her b-hCG levels were within normal limits. As patient presented to us with haemoperitoneum and on laparotomy, there was invasion into whole of the uterus, it could not be saved and hysterectomy was done.Faridpur Med. Coll. J. Jul 2017;12(2): 86-87

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Partial Hydatidiform Mole

International Journal of Gynecological Pathology ◽

10.1097/00004347-199310000-00006 ◽

1993 ◽

Vol 12 (4) ◽

pp. 315-323 ◽

Cited By ~ 61

Author(s):

M. D. Jeffers ◽

P. OʼDwyer ◽

B. Curran ◽

M. Leader ◽

J. E. Gillan

Keyword(s):

Hydatidiform Mole ◽

Partial Hydatidiform Mole

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Partial hydatidiform mole

10.32388/47z0zl ◽

2020 ◽

Author(s):

Keyword(s):

Hydatidiform Mole ◽

Partial Hydatidiform Mole

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Partial hydatidiform mole evolving into metastatic trophoblastic tumor: case report

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20201250 ◽

2020 ◽

Vol 9 (4) ◽

pp. 1713

Author(s):

I. Elmouri ◽

S. Tanouti ◽

H. Taheri ◽

H. Saadi ◽

A. Mimouni

Keyword(s):

Case Report ◽

Therapeutic Strategy ◽

Histopathological Examination ◽

Hydatidiform Mole ◽

Myometrial Invasion ◽

Multiparous Woman ◽

Partial Hydatidiform Mole ◽

Non Invasive ◽

Trophoblastic Tumor ◽

Partial Mole

Partial hydatidiform mole can evolve into a metastatic trophoblastic tumor. A 36-year-old, multiparous woman, pregnant with a 22-week embryonic hydatidiform mole, having spontaneously expelled. Histopathological examination showed a non-invasive partial mole. During biological monitoring, a trophoblastic tumor was diagnosed with pulmonary metastasis on CT-scan and myometrial invasion by MRI. Authors opted for a monochemotherapy with a good evolution. The potential risk of malignant transformation of the partial hydatidiform mole requires an adequate therapeutic strategy with strict monitoring.

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