Histomorphological changes and cytochrome P450 isoforms expression and activities in precision-cut liver slices from neonatal rats

Toxicology ◽  
2005 ◽  
Vol 206 (3) ◽  
pp. 427-438 ◽  
Author(s):  
A LUPP ◽  
M DANZ ◽  
D MULLER
Keyword(s):  
Cytochrome P450 ◽  
Neonatal Rats ◽  
Liver Slices ◽  
Cytochrome P450 Isoforms ◽  
Histomorphological Changes

Morphology and cytochrome P450 isoforms expression in precision-cut rat liver slices

Toxicology ◽  
2001 ◽  
Vol 161 (1-2) ◽  
pp. 53-66 ◽  
Author(s):  
A Lupp ◽  
M Danz ◽  
D Müller
Keyword(s):  
Cytochrome P450 ◽  
Rat Liver ◽  
Liver Slices ◽  
Cytochrome P450 Isoforms

Pharmacogenetics of Clozapine: In Vivo Role of Cytochrome P450 Isoforms and P-Glycoprotein

2008 ◽  
Vol 41 (05) ◽  
Author(s):  
E Jaquenoud-Sirot ◽  
B Knezevic ◽  
G Perla Morena ◽  
P Baumann ◽  
CB Eap
Keyword(s):  
Cytochrome P450 ◽  
P Glycoprotein ◽  
Cytochrome P450 Isoforms

scholarly journals In Silico Prediction of Drug–Drug Interactions Mediated by Cytochrome P450 Isoforms

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 538
Author(s):  
Alexander V. Dmitriev ◽  
Anastassia V. Rudik ◽  
Dmitry A. Karasev ◽  
Pavel V. Pogodin ◽  
Alexey A. Lagunin ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interactions ◽  
Cytochromes P450 ◽  
Investigational Drug ◽  
Web Resource ◽  
Average Accuracy ◽  
Structural Formulas ◽  
Cytochrome P450 Isoforms ◽  
Leave One Out ◽  
Important Drug

Drug–drug interactions (DDIs) can cause drug toxicities, reduced pharmacological effects, and adverse drug reactions. Studies aiming to determine the possible DDIs for an investigational drug are part of the drug discovery and development process and include an assessment of the DDIs potential mediated by inhibition or induction of the most important drug-metabolizing cytochrome P450 isoforms. Our study was dedicated to creating a computer model for prediction of the DDIs mediated by the seven most important P450 cytochromes: CYP1A2, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, and CYP3A4. For the creation of structure–activity relationship (SAR) models that predict metabolism-mediated DDIs for pairs of molecules, we applied the Prediction of Activity Spectra for Substances (PASS) software and Pairs of Substances Multilevel Neighborhoods of Atoms (PoSMNA) descriptors calculated based on structural formulas. About 2500 records on DDIs mediated by these cytochromes were used as a training set. Prediction can be carried out both for known drugs and for new, not-yet-synthesized substances. The average accuracy of the prediction of DDIs mediated by various isoforms of cytochrome P450 estimated by leave-one-out cross-validation (LOO CV) procedures was about 0.92. The SAR models created are publicly available as a web resource and provide predictions of DDIs mediated by the most important cytochromes P450.

Characterization of metabolites and cytochrome P450 isoforms involved in the microsomal metabolism of aconitine

2006 ◽  
Vol 844 (2) ◽  
pp. 292-300 ◽  
Author(s):  
Yuguang Wang ◽  
Shengqi Wang ◽  
Yongxue Liu ◽  
Liangping Yan ◽  
Guifang Dou ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Microsomal Metabolism ◽  
Cytochrome P450 Isoforms

Species Differences in Intestinal Metabolic Activities of Cytochrome P450 isoforms between Cynomolgus Monkeys and Humans

2011 ◽  
Vol 26 (3) ◽  
pp. 300-306 ◽  
Author(s):  
Haruka Nishimuta ◽  
Kimihiko Sato ◽  
Yasuyuki Mizuki ◽  
Masashi Yabuki ◽  
Setsuko Komuro
Keyword(s):  
Cytochrome P450 ◽  
Species Differences ◽  
Cynomolgus Monkeys ◽  
Cytochrome P450 Isoforms ◽  
Metabolic Activities

Do multiple cytochrome P450 isoforms contribute to parathion metabolism in man?

2003 ◽  
Vol 77 (6) ◽  
pp. 313-320 ◽  
Author(s):  
Elaine Mutch ◽  
Ann K. Daly ◽  
Julian B. S. Leathart ◽  
Peter G. Blain ◽  
Faith M. Williams
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Isoforms

Tissue-specific induction of the carcinogen-inducible cytochrome P450 isoforms in the gastrointestinal tract

2007 ◽  
Vol 24 (3) ◽  
pp. 297-303 ◽  
Author(s):  
Nancy Hernández-Martínez ◽  
Heriberto Caballero-Ortega ◽  
Víctor Dorado-González ◽  
Norma Labra-Ruiz ◽  
Jesús Javier Espinosa-Aguirre ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Gastrointestinal Tract ◽  
Tissue Specific ◽  
Specific Induction ◽  
Cytochrome P450 Isoforms

Investigation of the in Vitro Metabolism of Evodiamine: Characterization of Metabolites and Involved Cytochrome P450 Isoforms

2012 ◽  
Vol 27 (5) ◽  
pp. 705-712 ◽  
Author(s):  
Hong-Zhi Sun ◽  
Zhong-Ze Fang ◽  
Yun-Feng Cao ◽  
Xiao-Yu Sun ◽  
Mo Hong
Keyword(s):  
Cytochrome P450 ◽  
In Vitro Metabolism ◽  
Cytochrome P450 Isoforms

Role of Cytochrome P450 Isoforms in the Metabolism of Abamectin and Ivermectin in Rats

1996 ◽  
Vol 44 (10) ◽  
pp. 3374-3378 ◽  
Author(s):  
Zhaopie Zeng ◽  
Nicholas W. Andrew ◽  
Juliana M. Woda ◽  
Bruce A. Halley ◽  
Louis S. Crouch ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Isoforms
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