An in vitro study on reproductive toxicity of aluminium chloride on rabbit sperm: The protective role of some antioxidants

Toxicology ◽  
2007 ◽  
Vol 239 (3) ◽  
pp. 213-223 ◽  
Author(s):  
Mokhtar I. Yousef ◽  
Kamel I. Kamel ◽  
Marwa I. El-Guendi ◽  
Fatma M. El-Demerdash
Keyword(s):  
Reproductive Toxicity ◽  
In Vitro Study ◽  
Protective Role ◽  
Vitro Study ◽  
Aluminium Chloride

In Vitro Study of the Effect of Cypermethrin on Human Sperm Function, DNA Fragmentation and the Possible Protective Role of Vitamins C and/ or E

2012 ◽  
Vol 32 (1) ◽  
pp. 173-189
Author(s):  
Adel Zalata ◽  
Hussein Abdalla ◽  
Mohamed Serria ◽  
Amal Aziz ◽  
Sahar El-Dakroory ◽  
...  
Keyword(s):  
Dna Fragmentation ◽  
In Vitro Study ◽  
Human Sperm ◽  
Protective Role ◽  
Vitro Study ◽  
Sperm Function

scholarly journals Lithium as a prooxidant? A possible protective role of selenium – in vitro study

2017 ◽  
Vol 24 (3) ◽  
pp. 423-427 ◽  
Author(s):  
Irena Musik ◽  
Małgorzata Kiełczykowska ◽  
Barbara Rajtar ◽  
Łukasz Świątek ◽  
Małgorzata Polz-Dacewicz ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Protective Role ◽  
Vitro Study

In vitro Study of the Potential Protective Role of L actobacillus Strains by Acrylamide Binding

2014 ◽  
Vol 34 (1) ◽  
pp. 62-68 ◽  
Author(s):  
J.C. Serrano-Niño ◽  
A. Cavazos-Garduño ◽  
A.F. González-Córdova ◽  
B. Vallejo-Cordoba ◽  
A. Hernández-Mendoza ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Protective Role ◽  
Vitro Study

scholarly journals Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yan Che ◽  
Di-Fei Shen ◽  
Zhao-Peng Wang ◽  
Ya-Ge Jin ◽  
Qing-Qing Wu ◽  
...  
Keyword(s):  
Cardiac Remodeling ◽  
Cardiac Fibrosis ◽  
In Vitro Study ◽  
Protective Role ◽  
Vitro Study ◽  
Macrophage Infiltration ◽  
Control Group ◽  
Tgf Β1

Abstract Background Cardiac fibrosis is a crucial aspect of cardiac remodeling that can severely affect cardiac function. Cardiac fibroblasts surely influence this process. Besides, macrophage plays an essential role in cardiac remodeling after heart injury. However, whether macrophage influence fibroblasts remain a question worth exploring. This study aimed to define the role of berberine (BBR) on isoprenaline (ISO)-induced cardiac fibrosis in an in vivo rat model and try to figure out the mechanism in vitro study. Methods The Sprague-Dawley rats were divided into five groups: control group, ISO-treated group, and ISO + BBR (10 mg/kg/d, 30 mg/kg/d, and 60 mg/kg/d orally)-pretreatment groups. Fibrosis was induced by ISO administration (5 mg/kg/d subcutaneously) for 10 days. One day after the last injection, all of the rats were sacrificed. Using picrosirius red (PSR) straining, immunohistochemistry, immunofluorescence, flow cytometry, western blot, RT-qPCR and cell co-culture, we explored the influence of pretreatment by BBR on ISO-induced cardiac fibrosis. Results Our results showed that BBR pretreatment greatly limited ISO-induced cardiac fibrosis and dysfunction. Moreover, BBR administration reduced macrophage infiltration into the myocardium of ISO-treated rats and inhibited transforming growth factor (TGF)-β1/smads signaling pathways in comparison to that seen in the ISO group. Besides, in vitro study showed that BBR-pretreatment reduced ISO-induced TGF-β1 mRNA expression in macrophages and ISO stimulation of macrophages significantly increased the expression of fibrotic markers in fibroblasts, but BBR-pretreatment blocked this increase. Conclusion Our results showed that BBR may have a protective role to cardiac injury via reducing of macrophage infiltration and forbidding fibroblasts transdifferent into an ‘activated’ secretory phenotype, myofibroblasts.

Protective Role of Ascorbic Acid Against Asbestos Induced Toxicity in Rat Lung: In Vitro Study

1990 ◽  
Vol 13 (2-3) ◽  
pp. 249-256 ◽  
Author(s):  
Sikandar G. Khan ◽  
Shahid Ali ◽  
Qamar Rahman
Keyword(s):  
Ascorbic Acid ◽  
In Vitro Study ◽  
Protective Role ◽  
Vitro Study ◽  
Rat Lung

scholarly journals Role of glyoxalases in wound healing process: an in vitro study

2021 ◽  
Vol 165 ◽  
pp. 39
Author(s):  
Francesca Lombardi ◽  
Silvano Santini ◽  
Paola Palumbo ◽  
Valeria Cordone ◽  
Virginio Bignotti ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
In Vitro Study ◽  
Vitro Study ◽  
Wound Healing Process

scholarly journals TMIC-34. IN VITRO STUDY OF ROLE OF ASTROCYTIC S1P3 IN REGULATING BLOOD-BRAIN/TUMOR BARRIER PERMEABILITY

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi250-vi250
Author(s):  
Anurag N Paranjape ◽  
Brunilde Gril ◽  
Stephan Woditschka ◽  
Jeffrey Hanson ◽  
Xiaolin Wu ◽  
...  
Keyword(s):  
Brain Tumor ◽  
In Vitro Study ◽  
Vitro Study ◽  
Barrier Permeability ◽  
Blood Brain
Sign in / Sign up

Export Citation Format

Share Document