Multiple signal transduction pathways in okadaic acid induced apoptosis in HeLa cells

Toxicology ◽  
2009 ◽  
Vol 256 (1-2) ◽  
pp. 118-127 ◽  
Author(s):  
R. Jayaraj ◽  
Nimesh Gupta ◽  
P.V. Lakshmana Rao
Keyword(s):  
Signal Transduction ◽  
Okadaic Acid ◽  
Hela Cells ◽  
Signal Transduction Pathways ◽  
Multiple Signal ◽  
Induced Apoptosis

scholarly journals Butyric Acid Sensitizes Vero Cells to Ricin-Induced Apoptosis via Accelerated Activation of Multiple Signal Transduction Pathways

2003 ◽  
Vol 28 (5) ◽  
pp. 475-485 ◽  
Author(s):  
Tadashi Tamura ◽  
Naoko Tsuruta ◽  
Kaori Hirano ◽  
Kenichi Yamaguchi ◽  
Tatsuya Oda
Keyword(s):  
Signal Transduction ◽  
Butyric Acid ◽  
Vero Cells ◽  
Signal Transduction Pathways ◽  
Multiple Signal ◽  
Induced Apoptosis

Multiple signal transduction pathways regulate clusterin (gp 80) gene expression in MDCK cells

1996 ◽  
Vol 17 (2) ◽  
pp. 109-119 ◽  
Author(s):  
C Gutacker ◽  
R Flach ◽  
P Diel ◽  
G Klock ◽  
C Koch-Brandt
Keyword(s):  
Gene Expression ◽  
Signal Transduction ◽  
Tissue Injury ◽  
Mdck Cells ◽  
Signal Transduction Pathways ◽  
Epithelial Cell Line ◽  
Multiple Signal ◽  
Single Cell Type ◽  
Induced Apoptosis ◽  
The Individual

ABSTRACT Clusterin (gp 80, apolipoprotein J, TRPM-2) is a widely expressed multifunctional glycoprotein. Its demonstrated and proposed functions include the transport of lipids and membrane fragments, the inhibition of the cytolytic action of the terminal complement complex and the modulation of cell—cell interactions. The expression of the gene is enhanced during tissue injury and remodelling and by hormone-withdrawal-induced apoptosis of prostate and mammary cells. We show here that, in the kidney-derived epithelial cell line MDCK, clusterin mRNA is repressed by glucocorticoids and by progesterone. Treatment with epidermal growth factor also represses clusterin gene expression in MDCK cells. Incubation with 12-O-tetradecanoyl-phorbol-13-acetate, which activates protein kinase C (PKC), induces clusterin mRNA, while chelerythrine, an inhibitor of PKC, represses clusterin gene expression, suggesting that the clusterin gene responds to signalling pathways involving PKC. These results open up the possibility of studying the complex regulation of the clusterin gene by multiple signal transduction pathways within a single cell type, and most importantly, of characterizing interactions between the individual signal transduction cascades.

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