Lithium poisoning

In 1949 Cade1 introduced lithium into psychiatric use in Australia demonstrating its efficacy in the treatment of manic excitement. Unfortunately the drug almost immediately acquired a sinister reputation in the United States when its use as a salt substitute in cardiac patients caused a number of deaths from lithium poisoning.2 In Europe the advent of chlorpromazine and reserpine in the early 1950’s delayed the development of lithium; but in the last few years interest has revived as knowledge of fluid balance and mineral metabolism in affective disorders has increased.3

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TRANSPLACENTAL LITHIUM POISONING

The Lancet ◽

10.1016/s0140-6736(74)91919-9 ◽

1974 ◽

Vol 304 (7880) ◽

pp. 595 ◽

Cited By ~ 17

Author(s):

David Stevens ◽

David Burman ◽

Audrey Midwinter

Keyword(s):

Lithium Poisoning

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Phosphorus-Enriched Hemodialysis for the Treatment of Hypophosphatemia in a Patient with Severe Lithium Poisoning

Hemodialysis International ◽

10.1111/j.1492-7535.2004.0085ar.x ◽

2004 ◽

Vol 8 (1) ◽

pp. 95-95 ◽

Cited By ~ 1

Author(s):

S.b. Chebrolu ◽

S. Chaudhury ◽

A. Bidani ◽

C.m. Kjellstrand ◽

T.s. Ing

Keyword(s):

Lithium Poisoning

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Peritoneal dialysis for lithium poisoning.

BMJ ◽

10.1136/bmj.2.5764.749 ◽

1971 ◽

Vol 2 (5764) ◽

pp. 749-750 ◽

Cited By ~ 26

Author(s):

J H Wilson ◽

A J Donker ◽

G K van der Hem ◽

J Wientjes

Keyword(s):

Peritoneal Dialysis ◽

Lithium Poisoning

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Early digestive tract decontamination in acute-on-chronic lithium poisoning does not call conventional therapy into question

Clinical Toxicology ◽

10.3109/15563650.2013.824583 ◽

2013 ◽

Vol 51 (8) ◽

pp. 809-809

Author(s):

Marie Bretaudeau Deguigne ◽

Jean Francois Hamel ◽

David Boels ◽

Patrick Harry

Keyword(s):

Digestive Tract ◽

Conventional Therapy ◽

Lithium Poisoning

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Severe Lithium Poisoning

Drug Intelligence & Clinical Pharmacy ◽

10.1177/1060028081015007-814 ◽

1981 ◽

Vol 15 (7-8) ◽

pp. 598-599 ◽

Cited By ~ 5

Author(s):

Sally M. Marshall ◽

C. M. Kesson

Keyword(s):

Lithium Poisoning

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Síndrome de Neurotoxicidade Irreversível Causada por Lítio

Acta Médica Portuguesa ◽

10.20344/amp.7907 ◽

2017 ◽

Vol 30 (2) ◽

pp. 151

Author(s):

Ana Luísa Silva ◽

Carolina Ourique ◽

Filipe Martins ◽

Fernando Friões

Keyword(s):

Therapeutic Range ◽

Clinical Signs ◽

Signs And Symptoms ◽

Serum Levels ◽

Therapeutic Window ◽

Narrow Therapeutic Window ◽

Frequent Monitoring ◽

Lithium Poisoning

Lithium has a narrow therapeutic window. Frequent monitoring of both serum levels and clinical signs of toxicity is warranted because toxicity may be present even when concentrations are within the therapeutic range. We report the case of a man with lithium poisoning, with persistent neurologic signs and symptoms even after removal of lithium from circulation – a diagnosis of syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) was made.

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