In vitro hepatic biotransformation of the algal toxin pectenotoxin-2

Preliminary experiments were undertaken to examine the effect of three hydrazine derivatives, viz. Ro 4-4602, MK 486, and procarbazine hydrochloride, on hepatic microsomal drug metabolism in rats. All three compounds when given as pretreatment significantly prolonged pentobarbital sleeping time. In vitro, the hepatic microsomal N-demethylation of aminopyrine was inhibited. It is concluded that all three drugs are possible sources of clinically significant drug interaction when administered in combination with other agents which undergo hepatic biotransformation.

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HEPATIC BIOTRANSFORMATION PROFILES OF SULPHAMONOMETHOXINE IN FOOD-PRODUCING ANIMALS AND RATS IN VITRO

Acta Veterinaria Hungarica ◽

10.1556/avet.48.2000.3.6 ◽

2000 ◽

Vol 48 (3) ◽

pp. 293-300 ◽

Cited By ~ 4

Author(s):

N. Furusawa

Keyword(s):

Laying Hens ◽

Female Cattle ◽

Hepatic Biotransformation

Hydroxylation and acetylation of sulphamonomethoxine (SMM) and deacetylation of N4-acetyl SMM (N4-AcSMM) were estimated in liver post-mitochondrial supernatants (S-9) from laying hens, female cattle, swine and rats. The formation of hydroxylated SMM, 2,6-dihydroxy SMM (2,6-diOH-SMM), was found only with hen S-9s. N4-acetylation rate of SMM was the highest in pig S-9s, followed by rat, then hen or cow S-9s. All S-9s from the four species deacetylated N4-AcSMM. In hen S-9s, the rate of 2,6-dihydroxylation was higher during incubation at 41 °C than at 37 °C.

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Direct effects of the algal toxin, domoic acid, on ovarian function: Bovine granulosa and theca cells as an in vitro model

Ecotoxicology and Environmental Safety ◽

10.1016/j.ecoenv.2014.12.009 ◽

2015 ◽

Vol 113 ◽

pp. 314-320 ◽

Cited By ~ 5

Author(s):

Fabiola Pizzo ◽

Francesca Caloni ◽

Nicole B. Schreiber ◽

Luis F. Schutz ◽

Morgan L. Totty ◽

...

Keyword(s):

Domoic Acid ◽

In Vitro Model ◽

Ovarian Function ◽

Direct Effects ◽

Theca Cells ◽

Algal Toxin ◽

Vitro Model

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In vitro hepatic biotransformation of cepharanthine, a bisbenzylisoquinoline alkaloid

Planta Medica ◽

10.1055/s-0030-1264644 ◽

2010 ◽

Vol 76 (12) ◽

Author(s):

S Bory ◽

S Koeut ◽

S Bun ◽

B Baghdikian ◽

R Elias ◽

...

Keyword(s):

Bisbenzylisoquinoline Alkaloid ◽

Hepatic Biotransformation

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In vitro hepatic biotransformation of aldrin and dieldrin in food-producing animals

Acta Veterinaria Hungarica ◽

10.1556/004.49.2001.3.12 ◽

2001 ◽

Vol 49 (3) ◽

pp. 349-353

Author(s):

N. Furusawa ◽

Y. Morita

Keyword(s):

No Reduction ◽

Laying Hens ◽

Female Cattle ◽

Hepatic Biotransformation

The hepatic biotransformation of aldrin (AD) and dieldrin (DD) was studied in liver post-mitochondrial supernatants (S-9s) from laying hens, female cattle and swine. S-9s were incubated with 0.03 nmol o f AD or DD for 1 h. After 1 h, AD in the samples was almost epoxidated to DD. This formation was found with all the animal S-9s, and the highest rates occurred in pig S-9 (P < 0.01), followed by cow and hen S-9s. No reduction of DD was found with any of the S-9s.

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