aspalathus linearis
Recently Published Documents


TOTAL DOCUMENTS

230
(FIVE YEARS 60)

H-INDEX

35
(FIVE YEARS 4)

2022 ◽  
pp. 55-66
Author(s):  
Alvaro Viljoen ◽  
Weiyang Chen ◽  
Nduvho Mulaudzi ◽  
Guy Kamatou ◽  
Maxleene Sandasi
Keyword(s):  

Plants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2460
Author(s):  
Akeem O. Akinfenwa ◽  
Naeem S. Abdul ◽  
Fathima T. Docrat ◽  
Jeanine L. Marnewick ◽  
Robbie C. Luckay ◽  
...  

The green chemistry approach has continuously been applied for the synthesis of functional nanomaterials to reduce waste, environmental hazards, and the use of toxic chemicals among other reasons. Bioactive natural compounds have been found great potential in this regard and are used to improve the stability, activity, and biodistribution of metal nanoparticles (MNPs). Aspalathin (ASP) from Aspalathus linearis (rooibos) has a well-defined pharmacological profile and functional groups capable of both reducing and capping agents in the synthesis of metallic nanoparticles (NP). This study provides the first report of the phytomediated synthesis of gold and silver nanoparticles (AuNPs/AgNPs) via ASP and the green rooibos (GR) extract. The study demonstrated a green chemistry approach to the biosynthesis of nanoparticles of GR-AuNPs, ASP-AuNPs, GR-AgNPs, and ASP-AgNPs. The results showed that GR and ASP could act both as reducing and stabilising agents in the formation of crystalline, with different shapes and dispersity of NPs in the ranges of 1.6–6.7 nm for AgNPs and 7.5–12.5 nm for the AuNPs. However, the ASP NPs were less stable in selected biogenic media compared to GR NPs and were later stabilised with polyethene glycol. The cytotoxicity studies showed that GR-AgNPs were the most cytotoxic against SH-SY5Y and HepG2 with IC50 108.8 and 183.4 μg/mL, respectively. The cellular uptake analysis showed a high uptake of AuNPs and indicated that AgNPs of rooibos at a lower dose (1.3–1.5 μg/mL) is favourable for its anticancer potential. This study is a contribution to plant-mediated metallic nanoparticles using a pure single compound that can be further developed for targeted drug delivery for cancer cells treatments in the coming years.


2021 ◽  
pp. 100171
Author(s):  
Akinboro Adetayo ◽  
Adedosu Olaniyi Temitope ◽  
Badmus Jelili Abiodun ◽  
Adegbola Peter Ifeoluwa ◽  
Abubakar Mohammed Y ◽  
...  

2021 ◽  
Vol 11 (4) ◽  
pp. 205-209
Author(s):  
Muhammad Nabeel Ghayur ◽  
Anwarul Hassan Gilani

Plants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1936
Author(s):  
Akeem O. Akinfenwa ◽  
Naeem S. Abdul ◽  
Jeanine L. Marnewick ◽  
Ahmed A. Hussein

Skin cells suffer continuous damage from chronic exposure to ultraviolet light (UV) that may result in UV-induced oxidative stress and skin thinning. This has necessitated the formulation of cosmeceutical products rich in natural antioxidants and free radical scavengers. Aspalathus linearis (rooibos) is an endemic South African fynbos plant growing naturally in the Western Cape region. The plant is rich in phenolics and other bioactives with a wide spectrum of health benefits. The chemical study of an acetonic extract of green A. linearis afforded a novel compound named linearthin (1) and two known dihydrochalcones, aspalathin (2) and nothofagin (3). The chemical structure of the novel compound was elucidated based on spectroscopic data analysis. The bio-evaluation of the isolated chalcones in vitro for protection against UVB-induced oxidative stress were systematically assessed by examining cell viability, metabolic activity, apoptosis, and cytotoxicity using HaCaT and SK-MEL-1 skin cells models. It was observed that pre-treatment with tested samples for 4- and 24 h at low concentrations were sufficient to protect skin cells from UVB-induced damage in vitro as evidenced by higher cell viability and improved metabolic activity in both keratinocytes (HaCaT) and melanocytes (SK-MEL-1). The results further show that the pre-treatment regimen employed by this study involved some degree of cellular adaptation as evidenced by higher levels of reduced glutathione with a concomitant decrease in lipid peroxidation and lowered caspase 3 activity. Furthermore, compound 1 was most cytoprotective against UVB irradiation of HaCaT cell line (over 24 h) with an IC50 of 282 µg/mL and SK-MEL-1 cell line with IC50 values of 248.3 and 142.6 µg/mL over 4 and 24 h, respectively. On the other hand, HaCaT cells exposed to 2 over 4 h before UVB irradiation showed the highest degree of cytoprotection with an IC50 of 398.9 µg/mL among the four studied samples. These results show that linearthin (1) and the two glycoside dihydrochalcone of A. linearis have the potential to be further developed as antioxidant cosmeceutical ingredients that may protect skin against UVB-induced damage.


2021 ◽  
pp. 100481
Author(s):  
Analike Blom van Staden ◽  
Daniela Kovacs ◽  
Giorgia Cardinali ◽  
Mauro Picardo ◽  
Maribanyana Lebeko ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document