Importance of botulinum toxin in symptomatic treatment of Wilson's disease

Toxicon ◽  
2008 ◽  
Vol 51 ◽  
pp. 26
Author(s):  
Damásio Joan ◽  
Cardoso Márcio Neves ◽  
Magalhães Marina
Keyword(s):  
Botulinum Toxin ◽  
Wilson’S Disease ◽  
Symptomatic Treatment ◽  
Wilson's Disease

scholarly journals Effective Treatment of Neurological Symptoms with Normal Doses of Botulinum Neurotoxin in Wilson’s Disease: Six Cases and Literature Review

Toxins ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 241
Author(s):  
Harald Hefter ◽  
Sara Samadzadeh
Keyword(s):  
Botulinum Neurotoxin ◽  
Wilson’S Disease ◽  
Animal Experiments ◽  
Symptomatic Treatment ◽  
Wilson's Disease ◽  
University Hospital ◽  
Laboratory Findings ◽  
Dose Information ◽  
High Doses ◽  
The University

Background: Recent cell-based and animal experiments have demonstrated an effective reduction in botulinum neurotoxin A (BoNT/A) by copper. Aim: We aimed to analyze whether the successful symptomatic BoNT/A treatment of patients with Wilson’s disease (WD) corresponds with unusually high doses per session. Methods: Among the 156 WD patients regularly seen at the outpatient department of the university hospital in Düsseldorf (Germany), only 6 patients had been treated with BoNT/A during the past 5 years. The laboratory findings, indications for BoNT treatment, preparations, and doses per session were extracted retrospectively from the charts. These parameters were compared with those of 13 other patients described in the literature. Results: BoNT/A injection therapy is a rare (<4%) symptomatic treatment in WD, only necessary in exceptional cases, and is often applied only transiently. In those cases for which dose information was available, the dose per session and indication appear to be within usual limits. Conclusion: Despite the evidence that copper can interfere with the botulinum toxin in preclinical models, patients with WD do not require higher doses of the toxin than other patients with dystonia.

scholarly journals Jaw-opening oromandibular dystonia secondary to Wilson's Disease treated with botulinum toxin type A

2012 ◽  
Vol 70 (6) ◽  
pp. 407-409 ◽  
Author(s):  
Hélio A.G. Teive ◽  
Leandro E. Klüppel ◽  
Renato P. Munhoz ◽  
Nílson Becker ◽  
Paulo R. Müller ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Wilson’S Disease ◽  
Botulinum Toxin Type A ◽  
Case Series ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Wilson's Disease ◽  
Common Side Effect ◽  
Oromandibular Dystonia ◽  
Jaw Opening

We have reported a case series of five patients with jaw-opening oromandibular dystonia secondary to Wilson's disease (WD), in which the patients were treated with botulinum toxin type A (BTX-A). In all cases, dystonia score was partially reduced three weeks after injections. The most common side effect was transient mild dysphagia. This preliminary study showed that jaw-opening oromandibular dystonia in WD may be partially responsive to the use of BTX-A.

scholarly journals Wilson’s disease — hepatocerebral dystrophy

2018 ◽  
Vol 40 (2) ◽  
pp. 54-60
Author(s):  
Y. S. Tsimmerman
Keyword(s):  
Clinical Picture ◽  
Genetic Basis ◽  
Wilson’S Disease ◽  
Copper Metabolism ◽  
Symptomatic Treatment ◽  
Liver Lesion ◽  
Wilson's Disease ◽  
Extrahepatic Manifestations ◽  
Detailed Review ◽  
History Of

The article presents a detailed review of modern ideas on Wilson’s disease – hepatocerebral dystrophy. The definition, terminology, history of the study of the disease are stated. Special attention is paid to the analysis of the pathogenesis of hepatocerebral dystrophy, including the genetic basis of its development, the disturbance of copper metabolism. The clinical picture is thoroughly described, taking into account the characteristics of liver lesion and extrahepatic manifestations, diagnostics, classification. Particular attention is paid to the means of pathogenetic and symptomatic treatment.

Massive hepatic haemosiderosis in Wilson's disease

2000 ◽  
Vol 37 (2) ◽  
pp. 187-189 ◽  
Author(s):  
P Luca ◽  
L Demelia ◽  
S Lecca ◽  
R Ambu ◽  
G Faa
Keyword(s):  
Wilson’S Disease ◽  
Wilson's Disease

Wilson's disease and multiple sclerosis

2009 ◽  
Vol 40 (01) ◽  
Author(s):  
P Günther ◽  
W Hermann ◽  
A Wagner
Keyword(s):  
Multiple Sclerosis ◽  
Wilson’S Disease ◽  
Wilson's Disease

Different clinical presentation of Wilson's disease in identical twins

2015 ◽  
Vol 53 (05) ◽  
Author(s):  
D Németh ◽  
A Folhoffer ◽  
A Krolopp ◽  
S László ◽  
Z Gerlei ◽  
...  
Keyword(s):  
Wilson’S Disease ◽  
Clinical Presentation ◽  
Wilson's Disease ◽  
Identical Twins

Neurophysiologic classification of Wilson's disease by using cluster analysis

2006 ◽  
Vol 37 (01) ◽  
Author(s):  
W Hermann ◽  
T Villmann ◽  
HJ Kühn ◽  
P Baum ◽  
G Reichel ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Wilson’S Disease ◽  
Wilson's Disease
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