An electron microscopic study has been made of the axon terminal degeneration in the caudate nucleus in the cat after lesions in either the cerebral cortex, the thalamus, the cerebral cortex and the thalamus, the midbrain or within the caudate nucleus. Degenerating axon terminals can be recognized after a survival period of 4 days as dark, shrunken profiles with indistinct vesicles. After shorter survival periods the degenerating terminals contain swollen vesicles and have pale cytoplasm. After lesions in all the above sites there is degeneration of fine myelinated and nonmyelinated fibres. The degenerating terminals of all the afferent fibres to the caudate nucleus have asymmetrical membrane thickenings and end mainly on dendritic spines with a small proportion in contact with peripheral dendrites; after damage of the cerebral cortex or thalamus a few of the degenerating terminals also end upon main stem dendrites and cell bodies. The projection from the ipsilateral cerebral cortex is greater than that from the thalamus, which in turn is heavier than that from the contralateral cortex or midbrain. After lesions within the caudate nucleus degenerating terminals with symmetrical membrane thickenings are found in a region extending approximately 450 pm from the damaged part of the nucleus. These terminals make contact with nerve cell somata, main stem and peripheral dendrites and the initial segments of axons. After such a lesion of the caudate nucleus degenerating axon terminals with symmetrical membrane thickenings are also seen in the globus pallidus and the substantia nigra.
