Evaluation of 4 sensitizations in vitro testing methods for botanical mixtures: Proof-of-concept

2012 ◽  
Vol 211 ◽  
pp. S112-S113
Author(s):  
E. Andres ◽  
V.M. Sá-Rocha ◽  
E.L. Roggen ◽  
E. Corsini ◽  
S. Gibbs ◽  
...  
Keyword(s):  
In Vitro Testing ◽  
Proof Of Concept ◽  
Testing Methods

scholarly journals Evaluation of Different in Vitro Testing Methods for Mechanical Properties of Veneer Ceramics/ Евалуација На Тестовите In Vitro За Одредување На Механичките Особини На Порцеланските Маси За Фасетирање

PRILOZI ◽  
2015 ◽  
Vol 36 (1) ◽  
pp. 225-230 ◽  
Author(s):  
Aneta Mijoska ◽  
Mirjana Popovska
Keyword(s):  
Flexural Strength ◽  
Mechanical Characteristics ◽  
Testing Machine ◽  
In Vitro Testing ◽  
Biaxial Test ◽  
Testing Methods ◽  
Dental Ceramic ◽  
Universal Testing ◽  
Biaxial Tests

Abstract Metal-ceramic and all-ceramic prosthetic restorations in the patient mouth are often damaged by esthetic and functional problems that reduce their success and longevity. Аim: To evaluate methods for testing mechanical characteristics of dental ceramics through analysis of different testing methods. Material and methods: Dental ceramic materials are tested with in vivo and in vitro methods for their most important mechanical characteristics: hardness, toughness, flexural strength and abrasion. In vitro testing methods are faster and more efficient, without subjective factors from the patient according to ISO standards. Testing is done with universal testing machines, like Zwick 1445, Universal Testing Machine (Zwick DmbH & Co.KG, Ulm, Germany), Instron 4302 (Instron Corporation, England), MTS Sintech ReNew 1123 or in oral chewing simulators. Results: According to the testing results, flexure strength is one of the most important characteristic of the dental ceramic to be tested, by the uniaxial and biaxial tests. Uniaxial tests three-point and four-point flexure are not most appropriate because the main stress on the lower side of the tested specimens is tension that causes beginning fractures at the places with superficial flow. Uniaxial results for flexural strength are lower than actual force, while with biaxial test defects and flows on the edges of tested specimens are not directly loaded. Conclusion: Biaxial flexural method has advantages over uniaxial because of real strength results, but also for simple shape and preparing of the testing specimens.

UVA protection labeling and in vitro testing methods

2010 ◽  
Vol 9 (4) ◽  
pp. 516 ◽  
Author(s):  
Dominique Moyal
Keyword(s):  
In Vitro Testing ◽  
Testing Methods

Biocompatibility of calcium phosphate-coated and of geometrically structured nickel–titanium (NiTi) by in vitro testing methods

2004 ◽  
Vol 378 (1-2) ◽  
pp. 527-531 ◽  
Author(s):  
D. Bogdanski ◽  
M. Epple ◽  
S.A. Esenwein ◽  
G. Muhr ◽  
V. Petzoldt ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Nickel Titanium ◽  
In Vitro Testing ◽  
Testing Methods

In vitro chemosensitivity assay for patients with gynecologic sarcoma.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e13078-e13078
Author(s):  
Alessandro Santin ◽  
Joyce Varughese ◽  
John K. Chan ◽  
Candace McClure ◽  
Jayanthi Lea
Keyword(s):  
Drug Response ◽  
Tumor Response ◽  
Clinical Implications ◽  
In Vitro Testing ◽  
Testing Methods ◽  
Chemosensitivity Assay ◽  
Uterine Sarcomas ◽  
Response Testing ◽  
Precision Therapeutics

e13078 Background: This study describes the in vitro drug response of gynecologic sarcomas and clinical implications of in vitro testing. Methods: Ovarian or uterine sarcomas were analyzed for response to any of 7 drugs (carboplatin [Carb], cisplatin [Cis], paclitaxel [Ptx], docetaxel [Dtx], doxorubicin [Dox], gemcitabine [Gem], Ifosfamide [Ifo]) with a chemosensitivity assay (ChemoFx, Precision Therapeutics, Inc, Pittsburgh PA). In combination therapy, tumors were considered sensitive if responsive to at least 1 drug. Results: 68 tumors were analyzed (21 ovarian and 47 uterine; 54 primary and 14 recurrent; carcinosarcoma [n=53], leiomyosarcoma [n=13], other [n=2]). 24% of tumors were responsive to Carb, 30% to Cis, 33% to Ptx, 9% to Dtx, 18% to Dox, 26% to Gem, 27% to Ifo, 40% to Carb+Ptx, 39% to Cis+Ifo, 48% to Ptx+Ifo, 24% to Gem+Dtx, and 27% to Gem+Dox (Table). Ovarian sarcomas were more responsive than uterine sarcomas and primary more than recurrent tumors. Carcinosarcomas were more responsive than leiomyosarcomas to Ifo (P=0.02). Conclusions: In vitro tumor response testing may enable physicians to individualize chemotherapy regimens for their patients. [Table: see text]

scholarly journals Biopredictive in vitro testing methods to assess intestinal drug absorption from supersaturating dosage forms

2020 ◽  
Vol 56 ◽  
pp. 101275 ◽  
Author(s):  
Bart Hens ◽  
Makoto Kataoka ◽  
Keisuke Ueda ◽  
Ping Gao ◽  
Yasuhiro Tsume ◽  
...  
Keyword(s):  
Drug Absorption ◽  
Dosage Forms ◽  
In Vitro Testing ◽  
Testing Methods ◽  
Intestinal Drug Absorption

Urokinase Evaluated with the Experimental Radioactive Embolus

1967 ◽  
Vol 17 (03/04) ◽  
pp. 405-411
Author(s):  
M Hume
Keyword(s):  
Animal Experiment ◽  
Blood Clot ◽  
In Vitro Testing ◽  
Effective Agent

SummaryUrokinase and urokinase-activated plasmin have been given to the dog and rabbit. A thrombolytic state has been induced. Purified urokinase has induced lysis of the experimental radioactive blood clot embolus in the circulation. Demonstration of effectiveness in this animal experiment is hampered by inhibition of the agents in the circulation to a degree much greater than was noted in previous experiments with streptokinase. In vitro testing indicates that under proper conditions urokinase will be an effective agent in the treatment of human thromboembolism.

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