Estimation of the non-genotoxic effect level in vivo in bone marrow micronucleus tests for a rare disease drug candidate

2018 ◽  
Vol 295 ◽  
pp. S149
Author(s):  
L. Mueller ◽  
A. Zeller ◽  
M. Guerard ◽  
A. Poirier
Keyword(s):  
Bone Marrow ◽  
Rare Disease ◽  
Genotoxic Effect ◽  
Drug Candidate ◽  
Micronucleus Tests ◽  
Effect Level ◽  
Bone Marrow Micronucleus

scholarly journals Evaluation of genotoxic potential of amitraz by cytogenetic test in vivo

2006 ◽  
Vol 60 (3-4) ◽  
pp. 163-173 ◽  
Author(s):  
Ivana Pejin ◽  
Zoran Stanimirovic ◽  
Jevrosima Stevanovic ◽  
Zoran Kulisic
Keyword(s):  
Bone Marrow ◽  
Mitotic Index ◽  
Chromosomal Aberrations ◽  
Robertsonian Translocation ◽  
Bone Marrow Cells ◽  
Genotoxic Effect ◽  
Cytostatic Effect ◽  
The Third ◽  
Genotoxic Potential

The genotoxic effect of amitraz (3.6 mg/kg b.m, 1.8 mg/kg b.m, 0.9 mg/kg b.m) on bone marrow cells of HAN strain mice was examined in vivo by following the frequency of numeric and structural chromosomal aberrations, while the cytostatic effect of the same preparation was followed through the mitotic index. The first experimental dose (3.6 mg/kg b.m) caused a statistically significant (p<0.01) increase in the mitotic index, while the second (1.8 mg/kg b.m) and the third (0.9 mg/kg b.m.) experimental dose statistically significantly (p<0.01) decreased the value of the mitotic index in animals of both sexes. All the applied doses exhibited an ability to induce numeric (aneuploidy and polyploidy) and structural (Robertsonian translocation) chromosomal aberrations. It can be concluded on the basis of the obtained results that the examined substance exhibits a genotoxic dose-dependant effect. .

In vivo genotoxicity of selected herbicides in the mouse bone-marrow micronucleus test

1997 ◽  
Vol 71 (3) ◽  
pp. 193-197 ◽  
Author(s):  
T. Gebel ◽  
S. Kevekordes ◽  
K. Pav ◽  
R. Edenharder ◽  
H. Dunkelberg
Keyword(s):  
Bone Marrow ◽  
Micronucleus Test ◽  
Mouse Bone Marrow ◽  
Bone Marrow Micronucleus
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