Phosgene-induced lung edema: Comparison of clinical criteria for increased extravascular lung water content with postmortem lung gravimetry and lavage-protein in rats and dogs

2019 ◽  
Vol 305 ◽  
pp. 32-39 ◽  
Author(s):  
Wenli Li ◽  
Juergen Pauluhn
Keyword(s):  
Water Content ◽  
Extravascular Lung Water ◽  
Lung Edema ◽  
Lung Water ◽  
Clinical Criteria ◽  
Lung Water Content

Radiographic lung density assessed by computed tomography is associated with extravascular lung water content

2010 ◽  
Vol 54 (8) ◽  
pp. 1018-1026 ◽  
Author(s):  
V. V. KUZKOV ◽  
E. V. SUBOROV ◽  
M. Y. KIROV ◽  
K. WAERHAUG ◽  
R. MORTENSEN ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Water Content ◽  
Extravascular Lung Water ◽  
Lung Water ◽  
Lung Density ◽  
Lung Water Content

Effect of dehydration on interstitial pressures in the isolated dog lung

1989 ◽  
Vol 67 (2) ◽  
pp. 839-845 ◽  
Author(s):  
M. R. Glucksberg ◽  
J. Bhattacharya
Keyword(s):  
Blood Flow ◽  
Water Content ◽  
Extravascular Lung Water ◽  
Base Line ◽  
Inflation Pressure ◽  
Lung Water ◽  
Lung Expansion ◽  
Regional Lung ◽  
Lung Water Content

We have determined the effect of dehydration on regional lung interstitial pressures. We stopped blood flow in the isolated blood-perfused lobe of dog lung at vascular pressure of approximately 4 cmH2O. Then we recorded interstitial pressures by micropuncture at alveolar junctions (Pjct), in perimicrovascular adventitia (Padv), and at the hilum (Phil). After base-line measurements, we ventilated the lobes with dry gas to decrease extravascular lung water content by 14 +/- 5%. In one group (n = 10), at constant inflation pressure of 7 cmH2O, Pjct was 0.2 +/- 0.8 and Padv was -1.5 +/- 0.6 cmH2O. After dehydration the pressures fell to -5.0 +/- 1.0 and -5.3 +/- 1.3 cmH2O, respectively (P less than 0.01), and the junction-to-advential gradient (Pjct-Padv) was abolished. In a second group (n = 6) a combination of dehydration and lung expansion with inflation pressure of 15 cmH2O further decreased Pjct and Padv to -7.3 +/- 0.7 and -7.1 +/- 0.7 cmH2O, respectively. Phil followed changes in Padv. Interstitial compliance was 0.6 at the junctions, 0.8 in adventitia, and 0.9 ml.cmH2O-1.100 g-1 wet lung at the hilum. We conclude, that perialveolar interstitial pressures may provide an important mechanism for prevention of lung dehydration.

Effects of adenosine on extravascular lung water content in endotoxemic pigs

2001 ◽  
Vol 29 (12) ◽  
pp. 2371-2376 ◽  
Author(s):  
Stefan Kutzsche ◽  
Torstein Lyberg ◽  
Lars J. Bjertnaes
Keyword(s):  
Water Content ◽  
Extravascular Lung Water ◽  
Lung Water ◽  
Lung Water Content
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